Kevin Murach @KevinMurachPhD Twitter profile

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@fallendes

Kevin Murach

@KevinMurachPhD

1 year

I really like this comparison of mouse and human muscle by @DyarKen and @JonoSmith01 . This is in the supplements of the @NatRevMCB article with @JuleenRZierath . Don’t overlook the bonus coverage! #myotwitter

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Kevin Murach

@KevinMurachPhD

3 years

New paper in @ScienceMagazine . Muscle fiber repair in response to non-regenerative injury is satellite cell-independent and involves myonuclear relocation. A cool study that builds on a growing body of literature. #myotwitter

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

Muscle cell nuclei migrate to myofiber lesions to deliver mRNA locally for cellular repair.

www.science.org

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Kevin Murach

@KevinMurachPhD

1 year

This figure draws inspiration from the work of @brianglancylab and others and describes our current understanding of muscle structure and contraction. #myotwitter @MYOTWlTTER @JonoSmith01 @DyarKen @JuleenRZierath @NatRevMCB

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Kevin Murach

@KevinMurachPhD

1 year

A real tour de force on muscle hypertrophy! A big author line of heavy hitters. Well-done! Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions @DrMikeRoberts @kaesser and many more! #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

Who will win?

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Kevin Murach

@KevinMurachPhD

7 months

Satellite cells can fuse without first dividing during adult muscle fiber hypertrophy 🤯 Amazing work from @UKYCMB @AhmedIsmaeelPhD feat. @Thomas_Rando “Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus” #myotwitter

Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus

Abstract. Adult muscle stem cells (MuSCs) are known to replicate upon activation before differentiating and fusing to regenerate myofibers. It is unclear w

academic.oup.com

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Kevin Murach

@KevinMurachPhD

8 months

Fully-funded PhD position in my lab. Spread it around. Email me if you’re interested! #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

Shout out to @CBrightwellPhD @ChrisFryPhD Dr. Cory Dungan et al. @UKYCMB @UArkResearch @uacoehp for the cover shot in @APS_Function @APSPublications to go with our recent article. Muscle is so photogenic. #myotwitter

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Kevin Murach

@KevinMurachPhD

6 months

This is an amazing graphical abstract. I love making graphical abstracts and this is the level I’m striving for in 2024. Props to @OdedRechavi and team. Happy New Year!

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Kevin Murach

@KevinMurachPhD

3 years

🔥from @cbrightwellphd @chrisfryphd @UKYCMB @vectorlabsus #myotwitter This is the way.

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Kevin Murach

@KevinMurachPhD

10 months

I’m looking for a post-doc! In addition to working on a fun @NIHAging project, you get to live in one of the best outdoor recreation places in America, collaborate with great folks including @UACachexia and @AIMRC_UofA , and join a growing team. #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

Grad student presentations in my Muscle Phys class today and they hit me with this on the summary slide. 💯

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Kevin Murach

@KevinMurachPhD

7 months

Lifelong resistance training for the win! “The impact of life-long strength versus endurance training on muscle fiber morphology and phenotype composition in older men” #myotwitter @japplphysiol

The impact of life-long strength versus endurance training on muscle fiber morphology and phenotype...

Aging is typically associated with decreased muscle strength and rate of force development (RFD), partly explained by motor unit remodeling due to denervation, and subsequent loss of fast-twitch type...

journals.physiology.org

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Kevin Murach

@KevinMurachPhD

3 years

“Late-life exercise mitigates skeletal muscle epigenetic aging” in @AgingCell from my lab & @UKYCMB Drs. Yuan Wen, @cbrightwellphd , Christine Latham, Cory Dungan, @chrisfryphd and Drs. Andrea Wiley and Stan Watowich of Ridgeline Therapeutics. #myotwitter 🎄

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Kevin Murach

@KevinMurachPhD

4 years

Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice Some fun new work from @UKYCMB providing different explanations on cellular “muscle memory”. #myotwitter

Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and...

Background In the context of mass regulation, ‘muscle memory’ can be defined as long-lasting cellular adaptations to hypertrophic exercise training that persist during detraining-induced atrophy...

onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

1 year

What a treat to work with @JonoSmith01 @DyarKen and @JuleenRZierath on this @NatRevMCB review: Exercise metabolism and adaptation in skeletal muscle. I learned so much and the crew was amazing to work with! 🙏 to reviewers for great feedback #myotwitter

Exercise metabolism and adaptation in skeletal muscle

Nature Reviews Molecular Cell Biology - Skeletal muscles show high metabolic flexibility and functional plasticity in their response to different exercise modalities. Recent findings have advanced...

www.nature.com

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Kevin Murach

@KevinMurachPhD

3 years

Chipped away on this for about 18 months, taking our time to perfect the beat. The last satellite cell paper from my training days, and open access for you @jjmcca2_john @estheredupont @chrisfryphd @UKYCMB @FASEBorg and Dr. Charlotte Peterson #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

First paper for @RonaldGJones3 ! “A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle” in @JPhysiol feat. @UKYCMB @ChrisFryPhD @altos_labs Ridgeline Tx @UACachexia @UofA_ESRC et al. #myotwitter

A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in...

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

3 years

Always pumped to get some muscle on the cover! Thanks @APSPublications @APS_Function and congrats to first author Yuan Wen MD/PhD on his first cover (Dr. Wen brought you MyoVision as well...he’s incredible). #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

Collaboration for the win! 🎉“Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise” @UKYCMB @utmbhealth @uacoehp @APSPublications @APS_Function @ChrisFryPhD @CBrightwellPhD @NickTThomas #myotwitter

Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise

Abstract. Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Pr

academic.oup.com

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Kevin Murach

@KevinMurachPhD

3 years

It’s published at last! A massive cell atlas of muscle regeneration and a super awesome resource for the muscle field. Kudos to @bdcosgrove and his team #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

First day teaching as a faculty member. Only took 12+ years as a trainee to arrive at this point. Here we go!

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Kevin Murach

@KevinMurachPhD

3 years

Here’s the cover art for our most recent review in @FASEBorg Journal. It’s a “satellite” cell…get it!? I’ll see myself out. #myotwitter @UKYCMB @estheredupont @jjmcca2_john @chrisfryphd @biorender

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Kevin Murach

@KevinMurachPhD

1 year

Cover art for the newest issue of @JPhysiol given to article by @DrJimmyBagley @lancetdenes ! The art is called “Spheres of Influence” and was made by a dear friend of mine. @RonaldGJones3 article is in this issue too! #myotwitter @MYOTWlTTER

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Kevin Murach

@KevinMurachPhD

8 months

Our new review article on the role of miRNAs in satellite cells is free to download! @PJKoopmans @AhmedIsmaeelPhD @KasiaWhysall #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

A nice article by the legendary @GretchenReynold of @nytimes about our recent work on “muscle memory” published in @APS_Function @APSPublications @APSEEPSection also featuring work from @DrAdamPSharples @RobbySeaborne

How ‘Muscle Memory’ May Help Us Get in Shape (Published 2022)

Muscles develop a lasting molecular “memory” of past resistance exercises that helps them bounce back from long periods of inactivity.

www.nytimes.com

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Kevin Murach

@KevinMurachPhD

3 years

Cover art and a dram of bourbon (Eagle Rare single barrel store pick if you’re wondering….it doesn’t suck). Happy Friday #myotwitter @eaglerarelife @buffalotrace @glencairnglass

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Kevin Murach

@KevinMurachPhD

2 years

Pumped for our newest cover in @AJPCellPhys !!! @APSPublications @UKYCMB @uacoehp @UofA_ESRC #myotwitter

Christopher Fry

@ChrisFryPhD

2 years

Thrilled to see our image on the cover of @AJPCellPhys ! Confocal credit goes to our amazing crew @CBrightwellPhD @AlexKeeble5 @NickTThomas @ChristineLath @UKYCMB This was a fun review to write with @KevinMurachPhD @UofA_ESRC

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Kevin Murach

@KevinMurachPhD

3 years

Day 31: Honored and excited to join @UofA_ESRC @uacoehp @uarkansas and learn new things, start new collaborations, and work with eager students. Here’s a picture of @UACachexia Dr. Nic Greene and I unloading some of the samples I brought along. Fun times ahead! #myotwitter

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Kevin Murach

@KevinMurachPhD

1 year

A big review by @DrJimmyBagley and @lancetdenes w/ @jjmcca2_john @EricTWang in @JPhysiol “The myonuclear domain in adult skeletal muscle fibres: Past, present, and future” a labor of love from when Jimmy visited on his sabbatical. Great info! #myotwitter

The myonuclear domain in adult skeletal muscle fibres: past, present and future

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

2 years

New in @JPhysiol “Cross Talk proposal: Myonuclei are lost with ageing and atrophy” (Kirby/ Dupont-Versteegden) vs “Cross Talk opposing view: Myonuclei do not undergo apoptosis during skeletal muscle atrophy” (Schwartz/Gundersen) with rebuttals! #myotwitter

The Journal of Physiology

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

4 years

My first senior author paper, a @UKYCMB collaboration with @FerdinandvW @FondufeYvonne and others published in @EpigeneticsJ . The first insight into the myonuclear DNA methylome with hypertrophy in vivo! Data available at GSE144774 #myotwitter

The myonuclear DNA methylome in response to an acute hypertrophic stimulus

In addition to multi-nucleated muscle fibres, numerous resident and infiltrating mononuclear cells populate the muscle compartment. As most epigenetic assays in skeletal muscle are conducted on who...

www.tandfonline.com

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Kevin Murach

@KevinMurachPhD

2 years

A single cell atlas of adaptation to physical activity in young and aged mice by the great Dr. Tom Rando and coworkers (includes muscle). This will be a useful resource #myotwitter

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian...

Exercise has the ability to rejuvenate stem cells and improve tissue homeostasis and regeneration in aging animals. However, the cellular and molecular changes elicited by exercise have not been...

www.biorxiv.org

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Kevin Murach

@KevinMurachPhD

4 years

A slick cover image for our recent @APS_Function article. Props to the @UKYCMB crew @IVechetti @Doug_VanPelt @ChrisFryPhD and others!

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Kevin Murach

@KevinMurachPhD

2 years

Caught this while flying into Stockholm. #sweden #potofgold

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Kevin Murach

@KevinMurachPhD

7 months

Super pumped on the final version of our @APSPhysiology @APS_Function by @AhmedIsmaeelPhD and @NickTThomas that is now up online as well as the gorgeous cover art by @DrawImpacts ! #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

Back at it again with w/ @FerdinandvW @IVechetti “Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks” with open webtools for checking your favorite genes #myotwitter

Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for...

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely rare despite...

www.jbc.org

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Kevin Murach

@KevinMurachPhD

2 years

New @UKYCMB ! “Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons” Incl. scRNA-seq with exercise in a human @japplphysiol @APSPublications #myotwitter

Skeletal muscle properties show collagen organization and immune cell content are associated with...

In older individuals, hypertrophy from progressive resistance training (PRT) is compromised in approximately one-third of participants in exercise trials. The objective of this study was to establish...

journals.physiology.org

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Kevin Murach

@KevinMurachPhD

1 year

“MicroRNA Control of the Myogenic Cell Transcriptome and Proteome: The Role of miR-16” by @SeongLim7 feat. @DLee133 @Franmorena98 @PJKoopmans @IVechetti @FerdinandvW @UACachexia in @AJPCellPhys @APSPublications #myotwitter

MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16 | American...

MicroRNAs (miRs) control stem cell biology and fate. Ubiquitously expressed and conserved miR-16 was the first miR implicated in tumorigenesis. miR-16 is low in muscle during developmental hypertro...

journals.physiology.org

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Kevin Murach

@KevinMurachPhD

6 months

One for the road to wrap up 2023! Happy to share the stage with Prof. Peterson of @UKYCMB who has made big contributions to this area. “A muscle exercise research revolution powered by -omics at single cell and nucleus resolution” @BMCBiology #myotwitter

A muscle exercise research revolution powered by -omics at single cell and nucleus resolution - BMC...

bmcbiol.biomedcentral.com

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Kevin Murach

@KevinMurachPhD

3 years

New from M3R & @UKYCMB feat. @FerdinandvW “Epigenetic Evidence for Distinct Contributions of Resident and Acquired Myonuclei During Long-Term Exercise Adaptation Using Timed In Vivo Myonuclear Labeling” Open Access @AJPCellPhys @APSPublications #myotwitter

Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term...

Muscle fibers are syncytial postmitotic cells that can acquire exogenous nuclei from resident muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite cells during...

journals.physiology.org

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Kevin Murach

@KevinMurachPhD

2 years

“Myonuclear permanence in skeletal muscle memory: a systematic review and meta-analysis of human and animal studies” A complement to the recent Cross Talk in @JPhysiol #myotwitter

Myonuclear permanence in skeletal muscle memory: a systematic review and meta‐analysis of human and...

One aspect of skeletal muscle memory is the ability of a previously trained muscle to hypertrophy more rapidly following a period of detraining. Although the molecular basis of muscle memory remains...

onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

2 years

A short review by a first-year PhD student in the lab @PJKoopmans “Going nuclear: Molecular adaptations to exercise mediated by myonuclei”. Good job PJ! #myotwitter @UofA_ESRC @UARKHHPR @uacoehp @UofA_Research

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Kevin Murach

@KevinMurachPhD

2 years

Great trip to London with @CWSundberg for the @JPhysiol editorial board meeting. We of course found a place that had the good stuff for the right price too. Today was a good day.

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Kevin Murach

@KevinMurachPhD

6 months

Doing some holiday science with @PJKoopmans . Shout out to @miltenyibiotec for the BMW green Tyto #myotwitter

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Kevin Murach

@KevinMurachPhD

8 months

Cool images #myotwitter ! “Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration” @ScienceAdvances

Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during...

Live animal imaging platform reveals stage-dependent role of immune cells during muscle repair.

www.science.org

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Kevin Murach

@KevinMurachPhD

7 months

“Current limitations and future opportunities of tracer studies of muscle ageing”. An important read for muscle researchers studying aging and protein turnover! Lots of food for thought and things to consider. @JPhysiol #myotwitter

Current limitations and future opportunities of tracer studies of muscle ageing

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

3 years

It’s my last month as a post-doc in @UKYCMB To honor the people and projects from the last 6 y, over the next month I will post a paper we published together and tag the folks involved. Here’s my first pub from the lab circa 2016 @chrisfryphd #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

“A Glitch in the Matrix: The Pivotal Role for Extracellular Matrix Remodeling During Muscle Hypertrophy” by @CBrightwellPhD @UKYCMB @ChrisFryPhD Lots of great and current info in here! @uacoehp @UofA_ESRC @APSPublications @AJPCellPhys #myotwitter

A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypert...

Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of mononuclear...

journals.physiology.org

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Kevin Murach

@KevinMurachPhD

2 years

Provocative data from @benjaminfmiller @OMRF @AM_OMRF @UKYCMB @aga_borowik “Skeletal muscle nuclei in mice are not post-mitotic” @APS_Function @APSPhysiology @APSPublications #myotwitter

Skeletal Muscle Nuclei in Mice are not Post-mitotic

Abstract. The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie, myonuclei) are post-mitotic and unable to prolife

academic.oup.com

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Kevin Murach

@KevinMurachPhD

7 months

Very nice work here from Josh Drake’s team “Neuromuscular dysfunction precedes cognitive impairment in a mouse model of Alzheimer's Disease” @APS_Function @APSPublications @APSPhysiology #myotwitter

Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease

Abstract. Alzheimer’s disease (AD) develops along a continuum that spans years prior to diagnosis. Decreased muscle function and mitochondrial respiration

academic.oup.com

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Kevin Murach

@KevinMurachPhD

8 months

From @AhmedIsmaeelPhD @NickTThomas Coordinated Regulation of Myonuclear DNA Methylation, mRNA, And miRNA Levels Associates with The Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice #myotwitter @APS_Function

Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the...

Abstract. The central dogma of molecular biology dictates the general flow of molecular information from DNA that leads to a functional cellular outcome. I

academic.oup.com

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Kevin Murach

@KevinMurachPhD

2 years

Such a treat to read this. “Muscle is a stage, and cells and factors are merely players” from @Wi_Roman and Dr. Munoz-Canoves in @TrendsCellBio . Thanks for the sneak peek William! Great work. #myotwitter

Muscle is a stage, and cells and factors are merely players

The incredible ability of satellite cells to regenerate muscle has captivated much of the research field’s attention over the past decades. Versatile, enigmatic, vigorous, and skillful, the satellite...

www.cell.com

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Kevin Murach

@KevinMurachPhD

2 years

“Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence”. A study in human muscle. #myotwitter

Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and...

Aging | doi:10.18632/aging.204435. Kevin Perez, Serban Ciotlos, Julia McGirr, Chandani Limbad, Ryosuke Doi, Joshua P. Nederveen, Mats I. Nilsson, Daniel A. Winer, William Evans, Mark Tarnopolsky,...

www.aging-us.com

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Kevin Murach

@KevinMurachPhD

4 years

Do your mice even lift? A new review from @UKYCMB published in @APSPublications @japplphysiol where we summarize all the very recent advances in ways to “resistance train” your mice. Hopefully will be a good resource for the #myotwitter community!

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Kevin Murach

@KevinMurachPhD

2 years

An article about muscle memory in @washingtonpost @uacoehp @UofA_ESRC #myotwitter

Here’s what muscle memory really means, and how to use it

It turns out that muscle memory is not just in the mind. It's in the muscle fibers, too.

www.washingtonpost.com

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Kevin Murach

@KevinMurachPhD

3 years

Day 11: A book chapter on muscle mass regulation with Dr. John McCarthy. John gave me opportunity after opportunity to be successful. I am indebted to him. A great mentor. @jjmcca2_john #myotwitter @UKYCMB

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Kevin Murach

@KevinMurachPhD

3 years

Our newest work in @APSPublications @APS_Function Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle #myotwitter

Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal...

Abstract. Using a mouse model of conditional and inducible in vivo fluorescent myonuclear labeling (HSA-GFP), sorting purification of nuclei, low-input red

academic.oup.com

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Kevin Murach

@KevinMurachPhD

2 years

Our paper in @AJPCellPhys was published in its final form. Love the new look of the articles! Grateful that the summary figure was published in color, which I thought was scientifically justified. Thx to @UKYCMB @Ferdinandv , Drs. Wen and Dungan #myotwitter

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Kevin Murach

@KevinMurachPhD

8 months

From @PJKoopmans in collab with @AhmedIsmaeelPhD and @KasiaWhysall “The roles of miRNAs in adult skeletal muscle satellite cells”. Lots of questions still to answer! @SFRBM @UKYCMB @uniofgalway @UArkResearch @UofA_ESRC @UARKHHPR #myotwitter

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Kevin Murach

@KevinMurachPhD

1 year

The life and times of cellular senescence in skeletal muscle: friend or foe for homeostasis and adaptation? 💪🏻 @AJPCellPhys @APSPublications w/ @CoryDungan @UARKHHPR @uacoehp #myotwitter

The life and times of cellular senescence in skeletal muscle: friend or foe for homeostasis and...

A gradual decline in skeletal muscle mass and function is closely tied to increased mortality and disease risk during organismal aging. Exercise training is the most effective way to enhance muscle...

journals.physiology.org

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Kevin Murach

@KevinMurachPhD

3 years

Day 30: The minds behind the muscle! I was so fortunate to work with great mentors and colleagues @UKYCMB over the last 6 years (L to R): Drs. Charlotte Peterson, Chris Fry, John McCarthy, Esther Dupont-Versteegden, and Kate Kosmac. #myotwitter On to the next adventure✌️

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Kevin Murach

@KevinMurachPhD

1 year

I got to live my dream today. Picked a barrel of Weller Full Proof bourbon @BuffaloTrace . An experience I will never forget. #bourbon #Kentucky #singlebarrel #IYKYK

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Kevin Murach

@KevinMurachPhD

3 years

#myotwitter

Journal of Applied Physiology

@japplphysiol

3 years

#ImagesOfTheWeek : “Fiber typing human skeletal muscle with fluorescent immunohistochemistry” By: Kevin A. Murach, et al. Read more here: @universityofky @KevinMurachPhD @MarcasBamman #JAPPL #Immunohistochemistry

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Kevin Murach

@KevinMurachPhD

2 years

Hey #myotwitter join me in welcoming @corydungan . We were postdocs together @UKYCMB for 5 years and he now has his own lab @Baylor . I wouldn’t be where I am without him. He’s studying senescence in muscle among many many other things!

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Kevin Murach

@KevinMurachPhD

4 years

New stuff from @UKYCMB DNA damage more associated with obesity than aging in human skeletal muscle. Huge effort from my friend and colleague Dr. Cory Dungan!

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Kevin Murach

@KevinMurachPhD

3 years

Day 10: Hot off the press today! 🎉 Another brilliant piece from Dr. Yuan Wen, @DavisEnglund @UKYCMB Myonuclear transcriptional dynamics in response to exercise following satellite cell depletion #myotwitter

Myonuclear transcriptional dynamics in response to exercise following satellite cell depletion

Biological sciences; Stem cells research; Transcriptomics

www.cell.com

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Kevin Murach

@KevinMurachPhD

2 years

Thanks @NickTThomas for the #labswag hookup! Go with Stowebridge. They’re awesome. Can’t wait rock this stuff at IBEC next week! #myotwitter

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Kevin Murach

@KevinMurachPhD

4 years

A fun collaboration between @UKYCMB @Karolinskainst @VandreCF @FerdinandvW @IVechetti @Rodrigo_FerGo @gabezentner and others. The Genetic and Epigenetic Regulation of Skeletal Muscle Ribosome Biogenesis with Exercise

Genetic and Epigenetic Regulation of Skeletal Muscle Ribosome Biogenesis with Exercise

Ribosomes are the macromolecular engines of protein synthesis. Skeletal muscle ribosome biogenesis is stimulated by exercise, but the contribution of ribosomal DNA (rDNA) copy number and methylation...

www.biorxiv.org

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Kevin Murach

@KevinMurachPhD

4 years

Out today from @UKYCMB published in the new @APSPhysiology @APSPublications journal @apsfunction Function. A U of KY collaboration with @chrisfryphd @VandreCF and many others. 4+ years of experiments and happy to get this one out. Cheers. #myotwitter

Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy

Abstract. The “canonical” function of Pax7+ muscle stem cells (satellite cells) during hypertrophic growth of adult muscle fibers is myonuclear donation vi

academic.oup.com

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Kevin Murach

@KevinMurachPhD

2 years

I love being an Editorial Board Fellow as much as I love publishing in @JPhysiol !! This has been a great experience for me and encourage anyone who is interested to apply. Great people, great society, and great science. You can’t lose! #myotwitter

The Physiological Society

@ThePhySoc

2 years

Are you an #ECR wanting editorial experience with a prestigious journal? Apply for @JPhysiol 's Editorial Board Fellowship, where you'll gain valuable insight under the guidance of a Senior Editor. 🚨 Deadline: 14 Feb 🔗 Apply:

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Kevin Murach

@KevinMurachPhD

2 years

“The decrements in MHC II fibre function are primarily attributable to fibre atrophy, rather than age-related alterations in the intrinsic contractile mechanics” @JPhysiol @DrGregGrosicki @CWSundberg #myotwitter

Single muscle fibre contractile function with ageing

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

3 years

A really overdue paper in @JPhysiol from the Segal lab feat. Cornelison lab on how the vasculature remodels during severe muscle injury. Fundamental stuff here. Very cool. Great images too #myotwitter

Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

9 months

Resistance training for the win! #myotwitter

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺

@agingdoc1

9 months

Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial

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Kevin Murach

@KevinMurachPhD

2 years

We are hiring! “…especially interested in candidates with a research focus in metabolism (e.g. cell, tissue, or whole body metabolism). This includes, but is not limited to, research in obesity, diabetes, aging, cachexia, or any other conditions and interventions…” #myotwitter

UA Cachexia Lab

@UACachexia

2 years

Our program is looking for a new TT Assistant Prof with a focus in metabolism! Check it out! Great group of colleagues, exciting place to work on metabolism. Questions: npgreene @uark .edu @UARKHHPR @UofA_ESRC @AIMRC_UofA @KevinMurachPhD @tawashin45 @ProfSchmitt2 @QuinnLab_UofA

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Kevin Murach

@KevinMurachPhD

3 years

Looking for a lab technician/ manager in the Molecular Muscle Mass Regulation Laboratory here at U of Arkansas. Here’s the link to the @APSPhysiology job board where you can apply. DM me with questions! Please spread it around! #myotwitter

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Kevin Murach

@KevinMurachPhD

2 years

Dr. Cory Dungan with more 🔥 “Senolytic treatment rescues blunted muscle hypertrophy in old mice” in @GeroScienceAge @UKYCMB #myotwitter

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Kevin Murach

@KevinMurachPhD

4 years

New stuff from & @UKYCMB @DavisEnglund Satellite cell depletion disrupts transcriptional coordination and muscle adaptation to exercise, published in @APSPublications @APS_Function Single Myonuclear RNA-seq for the win! Way to go Dr. E

Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise

Abstract. Satellite cells are required for postnatal development, skeletal muscle regeneration across the lifespan, and skeletal muscle hypertrophy prior t

academic.oup.com

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Kevin Murach

@KevinMurachPhD

1 year

End of the year top golf outing with the @UofA_ESRC @UACachexia crew. Fortunate to be surrounded by great people! #myotwitter @FerdinandvW @Franmorena98 @STsitkanou @eleanor_schrems @PJKoopmans @RonaldGJones3 et al.

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Kevin Murach

@KevinMurachPhD

7 months

Nice! Thanks @AJPCellPhys @APSPublications @AJPCellPhysEIC ! This one got a nice cover as well #myotwitter @ChrisFryPhD

AJP-Cell Physiology

@AJPCellPhys

1 year

At Number 4 in the countdown of our most discussed articles of 2022 - A glitch in the matrix: the pivotal role for #ExtracellularMatrix remodeling during muscle #hypertrophy - #collagen #SkeletalMuscle @ChrisFryPhD @NickTThomas @KevinMurachPhD

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Kevin Murach

@KevinMurachPhD

3 years

New work on myotube exosomes from my guys @shredbehead and @IVechetti in his new lab! Skeletal Muscle Cell Growth Alters the Lipid Composition of Extracellular Vesicles #myotwitter Yet another way that EVs mediate their effects on recipient cells?

Skeletal Muscle Cell Growth Alters the Lipid Composition of Extracellular Vesicles

We sought to characterize the lipid profile of skeletal muscle cell-derived Extracellular Vesicles (EVs) to determine if a hypertrophic stimulus would affect the lipid composition of C2C12 myotube-...

www.mdpi.com

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Kevin Murach

@KevinMurachPhD

3 years

“Deletion of SA β-Gal+ cells using senolytics improves muscle regeneration in old mice”. Amazing work by Dr. Cory Dungan in @AgingCell w/ @UKYCMB in collab with @Boehringer and @chrisfryphd @cbrightwellphd @DavisEnglund et al. More to come #myotwitter 💪🏻

Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice

Aging Cell is an open access geroscience journal addressing the biology of aging, from molecular mechanisms of aging to age-related disease.

onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

2 years

I love that muscle on the cover! Congrats to @zr_hettinger @estheredupont @benjaminfmiller @UKYCMB #myotwitter @APS_Function @APSPublications

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Kevin Murach

@KevinMurachPhD

9 months

Good morning from Northwest Arkansas! A great place to explore. @AlliedCycle

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Kevin Murach

@KevinMurachPhD

2 years

A nice perspective by @DavisEnglund on @AbigailMackey1 ’s recent work in @JPhysiol “Therapeutic effects of recreational exercise on skeletal muscle aging – how much is enough?” #myotwitter

Therapeutic effects of recreational exercise on skeletal muscle ageing – how much is enough?

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

3 years

Some interesting work here from @DrAdamPSharples @RobbySeaborne et al. excited to read it! #myotwitter

Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle

The FASEB Journal publishes multidisciplinary basic and translational research covering biology and biomedical sciences at every level of organization.

faseb.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

2 years

Memories of the post-doc #myotwitter @aps_function @UKYCMB

Function

@APS_Function

2 years

#SuggestedRead "Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy" by Kevin A. Murach, et al. #tdTomato

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Kevin Murach

@KevinMurachPhD

2 years

Having a great time @karolinskainst with some amazing folks @FerdinandvW @Rodrigo_FerGo @Mark_Chapman10 @MeylerSamuel @Daniel_Muniz_ @LannerLab @norrbom_jessica @BaptisteJude2

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Kevin Murach

@KevinMurachPhD

2 years

When in Kentucky, you go to the distilleries. Never gets old. The best smell in the whole wide world is inside these buildings. 10/10 recommend @WoodfordReserve

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Kevin Murach

@KevinMurachPhD

6 months

Awesome work by @SebastianEdman @WiApro and team in @MolMetab For sure a candidate for @Matt_Muscle_Guy ’s totally biased list ;) #myotwitter

William Apró, PhD

@WiApro

6 months

After a very long and challenging year, it's great to end 2023 on a high note with our latest publication in Molecular Metabolism on fiber type-specific mitochondrial respiration led by the awesome @SebastianEdman

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Kevin Murach

@KevinMurachPhD

2 years

Thanks @AJPCellPhys for highlighting our work and @BioRender for the graphical tools #myotwitter @UKYCMB @UofA_ESRC @UofA_Research

AJP-Cell Physiology

@AJPCellPhys

2 years

This #review highlights the cellular, enzymatic, biochemical, & mechanical support the #ExtracellularMatrix provides to permit mechanical overload-induced #hypertrophy of #SkeletalMuscle : @ChrisFryPhD @KevinMurachPhD @CBrightwellPhD @NickTThomas @UKYCMB

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Kevin Murach

@KevinMurachPhD

3 years

My tweet about the recent paper on myofiber repair independent of satellite cells was my most popular to date. If you’re interested, we discuss some intricacies of myofiber repair without SCs during “physiological damage” in our recent review: #myotwitter

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Kevin Murach

@KevinMurachPhD

1 year

This was super fun! The @UABExerciseMed is a great crew and really appreciated the chance to share our work. Big things happening at @UABNews Thanks to @twbuford @ThalackerMercer @Matt_Muscle_Guy for the invite! #myotwitter

UAB Center for Exercise Medicine (UCEM)

@UABExerciseMed

1 year

Join us for UCEM's March 2023 DLS for a talk on "Exploring MYC in Muscle" by @KevinMurachPhD , Assistant Professor of Exercise Science, @UArkansas . Registration is required:

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Kevin Murach

@KevinMurachPhD

8 months

Awesome work from @CoryDungan @UKYCMB @Boehringer et al. SO much data in this one “Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice” @GeroScienceAGE #myotwitter

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses...

GeroScience - Skeletal muscle adaptation to external stimuli, such as regeneration following injury and hypertrophy in response to resistance exercise, are blunted with advanced age. The...

link.springer.com

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Kevin Murach

@KevinMurachPhD

3 years

Wow. #myotwitter

Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and...

Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which causes numerous morbidities and economic burdens in human populations. Mechanisms implicated in age-related...

www.medrxiv.org

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Kevin Murach

@KevinMurachPhD

2 years

Cool study by @MarniBoppart lab in @JPhysiol !!! “Development of a cell-free strategy to recover aged skeletal muscle after disuse” #myotwitter

Development of a cell‐free strategy to recover aged skeletal muscle after disuse

The Journal of Physiology publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

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Kevin Murach

@KevinMurachPhD

3 years

More muscle on the cover, this time from @ChrisFryPhD @bnoehren in @JPhysiol . Love to see it. #myotwitter

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Kevin Murach

@KevinMurachPhD

3 years

Glad to be appointed to the editorial board of @BMCBiology . Open access, flexible format submission, portable review (i.e. can transfer reviews from non-BMC journals!), scoop protection, and IF=7.4. Send your great muscle papers my way #myotwitter ✌️

BMC Biology

Find the latest research in BMC Biology, an open access journal with 5.4 Impact Factor, and 10 days to first decision. Open for submissions! As the ...

bmcbiol.biomedcentral.com

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Kevin Murach

@KevinMurachPhD

2 years

Pumped to work with Nathan Shock and my friend and colleague Dr. Wen! @UKYCMB @uacoehp @UofA_ESRC #myotwitter

Nathan Shock Centers

@NathanShockCtrs

2 years

We are excited to highlight 2021 Oklahoma NSC Pilot Awardees @KevinMurachPhD and Yuan Wen, MD/PhD. Read their NSC Pilot Awardee Spotlight here: . #AgingResearch @OMRF @AM_OMRF

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Kevin Murach

@KevinMurachPhD

7 months

Super pumped to have this giant of a man @CWSundberg here for the @AIMRC_UofA lecture today! #myotwitter

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