Professor
@ZMBHh
@UniHeidelberg
&
@mpi_mr_hd
. We engineer a synthetic model cell from scratch with lipid vesicles and DNA/RNA origami-based molecular hardware.
What happens when you apply design principles from bottom-up synthetic biology to immunology? In Heidelberg and together with
@FrischknechtLab
@platten_michael
& Oliver Fackler we compiled the prospects of bottom-up synthetic immunology
@NatureNano
Finally I can share that we have been celebrating an ERC starting grant! A big thank you first and foremost to my excellent group and to everyone who supported us along the way. Excited for
#SynCell
work with ENSYNC!
We built DNA-based mimicks of cytoskeletal filaments capable of reversible assembly and cargo transport inside cell-sized compartments. Now out
@NatureChemistry
!
I guess that's me🤗It still feels like dreaming the best dream ever. Stay tuned for synthetic cells, DNA nanotech and microfluidics. And get in touch if you are interested in Master, PhD or postdoc projects in what will hopefully become a fun & productive group!
📢🥳We are super excited to announce that
@KGoepfrich
will head a Max Planck Research Group at our institute from now on! As you can see, her lab space is still in the making. 🚧😁
@maxplanckpress
The ZMBH warmly welcomes Kerstin Goepfrich
@KGoepfrich
from
@mpi_mr_hd
as a new professor and research group leader. Her lab's research projects focus on biophysical engineering of life.
How can you build up structures on the inside of synthetic cells? With 3D laser printing. Very excited to share this work by
@ToAbele
et al
@Cluster3DMM2O
in Advanced Materials
Now
@NatureComms
: We realize a reaction pathway for synthetic cells that involves light-harvesting E. coli, pH-sensitive DNA origami and lipid vesicles
These beautiful DNA nanotube rings by
@majaillig
can actually contract! We start dreaming about an entirely synthetic division machinery for synthetic cells. Contraction mechanism with experiment, theory & simulation now out
@NatureComms
:
Thank you to an anonymous reviewer who recommended this book on the origins of life. Absolutely beautifully written, captivating and full of intersting thoughts.
Tips, tricks, tools and applications for the functionalization of cellular membranes with DNA nanotechnology - hope our new review
@TrendsinBiotech
is a useful resource:
@CavalcantiAda
Now
@NanoLetters
: Light-triggered lipid peroxidation can increase the spontaneous curvature. That's how we divide DNA-containing giant unilamellar lipid vesicles 👇
Happy 4th birthday to the group! Haven't quite reached the legal drinking age, but hey, it's Feuerzangenbowle. A big thank you to our academic family and friends, collaborators, supporters and, most importantly, all present and former members of the group
@mpi_mr_hd
and
@ZmbhH
I applied 2 years ago and now I have my own group
@mpi_mr_hd
. Full independance, competitive salary and research funding, choice of over 80 host institutes. Happy to share my experience and to give advice!
Call for Applications 2020/2021: We offer junior researchers again the possibility to apply for a position as a Max Planck Research Group Leader in all areas of science. Application deadline is October 22, 2020
#sciencecareer
#MPRGL
Dividing christmas baubles (i.e. GUVs) and their regrowth - online just on time
@angew_chem
We divide phase-separated GUVs with enzymatic reactions or locally with light & describe the process with an analytical model. Congrats Yannik Dreher,
@KeJahnke
🎄
WANTED: A
#postdoc
with experience in DNA origami or high-speed AFM, data analysis & a strong interest in synthetic biology. Join a friendly & motivated group
@mpi_mr_hd
@Cluster3DMM2O
in Heidelberg. Happy to help with fellowship applications. Please RT!
We are looking to establish a DNA origami synthesis core facilty
@UniHeidelberg
. If worked with
#DNAorigami
in your PhD, have experience with chemical synthesis and good organizational skills, please get in touch! RT appreciated.
Why are we so exited about RNA origami? It could be a unique intermediate between DNA origami and proteins for the construction of synthetic cellular hardware. We design and encode an RNA cytoskeleton in synthetic cells: Feedback very welcome!
We are looking for two
#postdocs
to join us: 1)
@ERC_Research
funded position in the context of RNA origami, cryoEM, synthetic cells, directed evolution; 2) A position in the excellence cluster
@Cluster3DMM2O
at the interface of chemistry & biology. Please share and get in touch!
Thrilled to announce that our initiative SynthImmune - engineering immune function with
#SynBio
- was selected for the excellence cluster competition
@dfg_public
! Exciting science ahead with the best co-speakers Oliver Fackler &
@michael_platten
& colleagues
@UniHeidelberg
🥳
Curious about the new world of RNA origami and why we are so excited about it? Check out our review Kudos to a number of excellent scientists in the field.
The credits for this go to my group! This is the time to say thank you to all current and former members of the team and to our friendly, supportive and collaborative academic family.
Congratulations to our 3 WIMA winners:
@KGoepfrich
, Jinghui Liu, and Shikha Dhiman! It was a true joy to see all this exciting, high quality research and a great way to build a nice network! Looking forward to the next WIMA Award 2022....
Thank you very much
@UniHeidelberg
and
@ZmbhH
for the nomination and to all our mentors, collaborators and funders for their support over the years. This one goes to the group!
Förderpreis für Heidelberger Molekularbiologin:
Kerstin Göpfrich erhält hochdotierte Auszeichnung der Alfried Krupp von Bohlen und Halbach-Stiftung
@KGoepfrich
@ZmbhH
Synthetic cells are on the move - quite literally: The Schwille
@MPI_Biochem
and Frey groups
@LMU_Muenchen
recently showed how mechanochemical feedback loops drive the persistent motion of liposomes. Here is my News & Views
@NaturePhysics
:
Two lessons on science communication from the COVID pandemic: 1) We should communicate science before it becomes emotional. 2) We have to reach a broad audience. In that sense big thank you to Apothekenumschau for writing about DNA origami and our work
@SynthImmune
!
We are excited to share our
@biorxivpreprint
: DNA microbeads as organoid-internal sources of morphogens guide organoid development We are happy to share the DNA beads if you want to try it out! Congrats
@AftingCassian
@ToWalther
and thanks
@WittbrodtLab
I am looking for a PhD student and a postdoc to join our brand new Biophysical Engineering Group
@mpi_mr_hd
in Heidelberg Interested in DNA origami and 3D printing for synthetic cells? Happy to chat at the
#BiomembraneDays
!
Last year we met with about 60 scientists for 2 weeks to discuss what it means to synthesize life. Here is the summary of our discussion: We hope it represents diverse views and serves as a roadmap towards a big vision. Feedback welcome!
Undergrads: Interested in SynBio and in a 5-year Master-to-PhD programme at some of the best institutions in Germany (taught entirely in English)? Please apply! RT appreciated.
📣 You can now apply to the Max Planck School Matter to Life and join us in 2024! 🔥 Whether you apply to the MSc to PhD Direct Track Program or our ten-week paid research internships - we are looking forward to your application! (Deadline: 1 Dec, 2023)
Congratulations to
@maiptran21
for winning the poster prize at
#FDN2024
for her work on RNA origami. The group is proud of you🙌Thanks to the FDN crowd!
Our (
@KeJahnke
@max_igaev
@CompBioPhys
) preprint is online: With experiments & MD we show that one can shape the energy landscape for dynamic reconfiguration of DNA nanostructures without changing the DNA sequence. Feedback is very welcome!
Deeply sadened to hear that Ned Seeman passed away. He turned Esher's fish into DNA and us into DNA nanotechnologists. Thank you to a brilliant scientist for bringing a new field to life.
Want to lead a brand new DNA foundry in Heidelberg? Want to write the code for synthetic life? We are recruiting the head of the Carl Zeiss Synthetic DNA accelerator lab! Please RT, get in touch & apply now
#SynBio
🧬👇
Great conversation with
@KGoepfrich
about engineering artificial cells from scratch! We talk all things synthetic biology, from the challenges of building the various required components, to the ethics of potentially creating a whole new branch of life.
"The power lies in a big idea" - That's why creating life from non living building blocks should be a key focus of research in Europe. Thank you to the European Parliament for hosting us!
Thank you to Ivars Ijabs
@ijabs
and the European Parliament for hosting today's meeting, to all the participants, and to the speakers who have shown that Nature is our next
#technology
and that support is needed to accelerate
#syncell
#research
and technological developments!
Much as a train switchyard can steer rail cars to different locations, researchers have engineered protein motors to carry tiny bits of cargo to different locations.
First part of our group retreat in Lausanne. Thank you
@YSchaerli
and
@caiyizhi
et al for a truly exciting meeting!
#swissuksynbio
Finally we also have a new group picture. 🙏
Editorial alert! The intersection of bottom-up synthetic cell engineering and nanobiotechnology Thanks
@palankarr
and
@NatureNano
for shring our excitement for building a cell!
What a day! Huge congratulations to Dr Dreher aka Dr GUVenator! Thanks to
@graeter_mbm
, Christine Selhuber-Unkel
@MSE_UNIHD
and Joachim Spatz and the whole BPE group for their support.
Our new paper is out: Actin-containing cell-sized droplets move autonomously due to Marangoni flows. We engineer their directed rotational and translational motility, which can persist for hours!
@KGoepfrich
@mpi_mr_hd
@Cluster3DMM2O
@AdvSciNews
We used this 👇to pull lipid nanotubes from vesicles and cells. Sometime nature's machines can do what we as biophysicists would normally do with AFMs or optical tweezers!
I am very proud of Kevin! Thank you for being brave enough to join a new lab as the first PhD student. And thanks for all the visible and invisible (!) support we received from
@mpi_mr_hd
@Cluster3DMM2O
and collaborators.
I am very excited to have submitted my PhD thesis today! Thank you very much
@KGoepfrich
as well as all collaborators, colleagues and fantastic students for these exciting years!
@mpi_mr_hd
I am very happy and excited to see the support for life inspired molecular systems engineering in Heidelberg! Thanks to all the excellent colleagues who contributed to this success.
Neuer Forschungsbau für das Engineering von lebensinspirierten molekularen Systemen: Wissenschaftsrat hat Empfehlung für den Neubau ausgesprochen – Raum für innovatives Forschungsprogramm in den Ingenieurwissenschaften
Dear MSc students, we have an awesome summer prgramme for you (lots of interesing connections if you are looking for a
#PhD
!) Apply by June, 20th Thank you to my colleagues
@Cluster3DMM2O
for putting this together. Please RT.
Exciting postdoc grant! In close collaboration with
@EllenbergLab
@EMBLHeidelberg
we want to remodel nuclear membranes with RNA origami Funded by
@ResearchLifesci
Please get in touch if you are interested!
It is a great honour to introduce my first PhD student and founding member of the Biophysical Engineering group
@mpi_mr_hd
:
@KeJahnke
. He is building dynamic systems with DNA nanotechnology and microfluidics. Follow him for updates from our group (and pretty microscope images)!
I thought I prepared a surprise for my grandparents diamond wedding – used a deep learning tool to convert their black-and-white wedding pics into full color 👰♂️🤵♂️My grandfather’s reaction: Oh yes, I know, I did the same for our family tree 😬 Not quite what I expected...
We are counting the days until the 75th anniversary of the founding of the Max Planck Society
@maxplanckpress
🎊
That's why we are browsing through the history of our own institute. What do you think: Did
@KGoepfrich
's group do a good job in recreating this historical image?👩🔬📽️
I am sad and at the same time very proud to see the first PhD student leave the group. A big thank you and all the best for your future Dr.
@KeJahnke
!
I am thrilled to announce that as of next week I will be joining the Weitz Lab
@Harvard
for my postdoc! Looking forward to start a new adventure in this interdisciplinary and exceptional research environment
We'd like to thank and acknowledge
@KGoepfrich
for exceptional contributions to peer review. Congrats Dr Kerstin Göpfrich on being our first 2022 reviewer of the month!
Fantastic talk by
@CavalcantiAda
at
#EBSA2023
on receptor-mediated regulation of cell mechanics. Here are the references for our collaboration on the DNA nanotech tools if you want to give them a try:
Synthetic biology aims to tackle disease and give cells superpowers Thank you
@KatieKrypton
for writing about our work and our vision to build a cell from skratch!
Beautiful cover of Ned Seeman's vision of DNA crystals. It is an honor to contribute to the special issue
@BiophysJ
dedicated to a brilliant scientist with our DNA origami polyominos
A shoutout to the bioprinting community: Commonly used photoresist molecules permeate accross cellular membranes. For guidance on which ones to use, check out our new paper
@AdvSciNews
: