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John Streicher Profile
John Streicher

@JohnStreicher1

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I'm a biomedical scientist at the University of Arizona. I study opioid receptor signal transduction, with the goal of developing non-addictive pain drugs

Tucson, AZ
Joined July 2019
Don't wanna be here? Send us removal request.
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@JohnStreicher1
John Streicher
5 months
Our paper on the efficacy and mechanism of Cannabis terpenes in chronic pain just went live! Led by the talented Abby Schwarz. We found they produce strong pain relief by activating the Adenosine A2a Receptor in spinal cord. Check it out!
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@JohnStreicher1
John Streicher
5 months
@NiohBerg I feel for her. No one should have to go through that. I also saw a Palestinian father carrying his dismembered child in a bag. Maybe we could do something about that??
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@JohnStreicher1
John Streicher
2 years
If you think abuse is "very rare" in academia then this most likely means none of the students trust you enough to tell you about it.
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@JohnStreicher1
John Streicher
3 years
Got notice from my PO today that one of my R01s will be funded. The wild thing is I don't even feel happy or thrilled. Just a profound sense of relief. I get to keep my job. I won't have to jeopardize the careers of all my students. What a weird system we've built for ourselves.
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@JohnStreicher1
John Streicher
3 years
I work at a giant fucking university. UPS delivered a package and said they "left it at the front door." 🀨
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@JohnStreicher1
John Streicher
2 months
@ParkerMolloy "Every insult is the n-word, except the n-word, which is Free Speech"
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@JohnStreicher1
John Streicher
3 years
Let's be real folks. It's not PIs keeping postdocs from being paid $100k+. That salary plus fringe is HALF of a modular R01. Plus PI salary support and supplies then an entire R01 becomes the personal grant of one PD. Not sustainable. Funding levels must rise for this to happen.
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@JohnStreicher1
John Streicher
2 years
Junior faculty watch their labs wither and die for a lack of a $250k/yr grant while these...people...line up to give a sex creep fired for misconduct $25m. Sick.
@BillAckman
Bill Ackman
2 years
I am pleased to announce that last night at @PershingSqFdn scientific advisors dinner, we announced that we found a 50% funding partner for the new Sabatini lab.The new lab now has $5m of funding per year for five years. David is now making launch preparations for the lab. Allez!
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@JohnStreicher1
John Streicher
5 months
I could write "Western blot" in my papers or I could write "we zapped proteins with force lightning to make them run through Science Jello, then zapped them sideways onto gun cotton, then soaked them in salty milk and glow-in-the-dark rabbit blood so we could see them" πŸ€”
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@JohnStreicher1
John Streicher
2 years
@ProfBootyPhD @shreyabasu003 "In entertainment news, Beyonce shocked the world with a surprise wedding to a mysterious figure only known as 'Mr Smeg.'"
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@JohnStreicher1
John Streicher
4 years
I’ve been beating my head against the grant brick wall for years. I was marinating in pessimism and unsure if I’d have a lab by this summer. Now in the space of a week I’ve gotten a 3rd and 4th percentile score on 2 R01s. I literally can’t believe it.
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@JohnStreicher1
John Streicher
2 years
@nisslbodies @katiedimartin May you suffer in darkness, John
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@JohnStreicher1
John Streicher
2 years
You know, we already have a big journal that will review everything you send it, makes no decisions on impact, and has a decent rep. It's PLOS ONE. Does everyone treat it like the future of science? No they treat it as a dump journal for stuff you can't get published elsewhere.
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@JohnStreicher1
John Streicher
6 months
@lee_kovarsky My feelings exactly. We professors have a special duty of care to our students. Labeling our students as terrorists is a gross violation of that duty
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@JohnStreicher1
John Streicher
11 months
Thrilled to report my grant went from a 12th percentile to Not Discussed!! πŸŽ‰πŸŽ‰πŸŽ‰ (I need a drink)
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@JohnStreicher1
John Streicher
2 years
Whoever invented the Jan 5 NIH deadline needs to be brought up on charges for crimes against humanity
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@JohnStreicher1
John Streicher
2 years
By age 30 you should have a paper desk rejected by Cell, Nature, AND Science.
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@JohnStreicher1
John Streicher
1 year
Unacceptable. For all the people promising to boycott eLife until they fired Mike Eisen, I’ll boycott eLife until they reverse this chilling rejection of academic freedom
@mbeisen
Michael Eisen
1 year
I have been informed that I am being replaced as the Editor in Chief of @eLife for retweeting a @TheOnion piece that calls out indifference to the lives of Palestinian civilians.
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@JohnStreicher1
John Streicher
11 months
Let’s be real, shall we? A PhD obviously increases your earning potential. Denying it just sounds like privilege
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@JohnStreicher1
John Streicher
5 months
Me every time a Western blot works
@SterlingCooley
Sterling Cooley
5 months
We made it - we fucking made it This is really going to happen Holy shit Dementia and Alzheimer’s is as good as cured as of Today We are coming to rescue your microtubules - hang on just a few more months Hang on to your loved ones - you must not let them slip away ❀️❀️❀️
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@JohnStreicher1
John Streicher
2 years
Teaching neuropharm today
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@JohnStreicher1
John Streicher
3 years
@petersm_th We were here first. The title goes back to the Middle Ages and was used to refer to scholars of the highest achievement e.g. Doctor Thomas Aquinas. The term wasn't common for medical professionals until the mid-1700s.
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@JohnStreicher1
John Streicher
7 months
This is nonsense. Many positions in industry, consulting, etc require a PhD. Please don't pay this person to find you a job.
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@ashleyruba_phd
Ashley Ruba, PhD
7 months
A tough pill to swallow: PhDs have spent a decade in post-secondary education for a degree that is essentially meaningless in the business world. It is completely valid to feel regret, anger, and/or despair about this. Don't let it paralyze you.
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@JohnStreicher1
John Streicher
10 months
Hey prospective grad students, I may not be UCSF, but all my students have graduated in 4 years or less. Think about it!
@drugmonkeyblog
Drug Monkey
10 months
UCSF Graduate Division statistics: median time to degree is 5.75 years. 5-7.25 appears to be the meat of the distribution.
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@JohnStreicher1
John Streicher
3 years
Tenure approved! Now I’m an Associate of the Professor instead of the Assistant to the Professor! Maybe someday I’ll be an actual Professor...
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@JohnStreicher1
John Streicher
9 months
How absurd is this getting? 1,465 mice over 26 (!) figures just to get into a solid society journal. Even then we’re fighting tons of negative comments and requests for more. We’ve all gone insane
@JohnStreicher1
John Streicher
9 months
It's 1,465. Yes, for one paper! 😬 I'm sure this knowledge will blow the Reviewer's mind
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@JohnStreicher1
John Streicher
1 year
Just got the notice - promotion to full Professor. When I was younger I never would have thought I'd be here. It's only a long line of amazing trainees like @Viva_LaVig and @_KatherinG18 that have made this day possible. Thank you all.
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@JohnStreicher1
John Streicher
3 years
@HCCvPDAC @ardemp @NIH "Nobel already awarded; no longer innovative."
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@JohnStreicher1
John Streicher
2 years
Science is a social ecosystem. It works because we all make it work. Predators might get money, but we can deny them a place in our ecosystem. Refuse to review his manuscripts. Deny him speaking slots. Refuse to work for or with him. We can stand up for our collective values.
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@JohnStreicher1
John Streicher
1 year
Why is it callous as some of you say to express sympathy with the Palestinian people? The original Onion article is satirizing an actual event where a Palestinian man who had just lost 6 of his family was asked to condemn Hamas. Why does Eisen deserve your rage and boycott?
@mbeisen
Michael Eisen
1 year
The Onion speaks with more courage, insight and moral clarity than the leaders of every academic institution put together. I wish there were a @TheOnion university.
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@JohnStreicher1
John Streicher
11 months
Everyone should understand the way that our profession functions. Not sure why this tweet is making everyone so mad, but the numbers are reasonable, he's not lying or making them up. Knowledge is power
@pauldauenhauer
Paul J. Dauenhauer
11 months
How much does a graduate student cost per year? Salary: $35,793 Benefits + Tuition: $26,463 Supplies: $12,000 Travel: $3,000 Overhead: $42,491 Total: $119,747
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@JohnStreicher1
John Streicher
10 months
See, this is why you need to be careful with your SciComm. There isn’t a flash of light, there’s a puff of zinc atoms. But now thanks to this there’s dozens of people in the comments talking about souls and the spark of life. Don’t do this people, the clicks aren’t worth it
@gunsnrosesgirl3
Science girl
10 months
At the exact moment of conception, when the sperm meets the egg there is a flash of light 1/2 πŸ“ΉNorthwestern University
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@JohnStreicher1
John Streicher
1 year
I thought I knew shitty grant reviewers - then I started putting in more F30/F31 apps with my students. Holy shit it's a whole new world of absurdity. Apparently publishing ~10 papers a year as a mentor is a "sparse publication record"????? Not to mention the factual errors...
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@JohnStreicher1
John Streicher
2 years
LMAO
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@JohnStreicher1
John Streicher
8 months
My first postdoc Wei Lei just got tenure πŸ₯°
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@JohnStreicher1
John Streicher
1 year
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@JohnStreicher1
John Streicher
2 years
Can anyone explain why Prism β€œisn’t transparent” when each test has the equations used to calculate it in the help text? The same standard math we’ve been using for decades? Doesn’t seem that obscure.
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@JohnStreicher1
John Streicher
8 months
My daughter's Science Fair project advances to the next level of competition! REVIEWER 2 HAS BEEN DEFEATED!
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@JohnStreicher1
John Streicher
1 year
New Abcam record for a simple primary antibody - $655 🫠
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@JohnStreicher1
John Streicher
2 years
"No one can get postdocs." "People are leaving academia." "New grads aren't going into postdocs anymore." Is there any data for these common assertions? Would like to see it, instead of going off of Twitter vibes.
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@JohnStreicher1
John Streicher
1 year
This thread is an example of why scientists have a DUTY to be responsible with our work. I looked up the study. The effects are in the MILLIMOLAR range using in vitro assays for a chemical the authors themselves note is less than a mg in common exposure. Highly irresponsible.
@TheMcKenziest
Lauren McKenzie
1 year
Sucralose is damaging our DNA
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@JohnStreicher1
John Streicher
2 years
Well I finally pissed off reactionary Twitter. David Sabatini did the trick. I welcome your hatred, it tells me I’m on the right path. Defending an abuser is very on brand for you folks.
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@JohnStreicher1
John Streicher
1 year
@hecubian_devil Hey now, it's extremely important that we make no changes at all to the high literary canon that is Stephen King novels!
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@JohnStreicher1
John Streicher
11 months
@ScientistsLift Academia isn’t that bad, it has positives and negatives like any other job or field
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@JohnStreicher1
John Streicher
2 years
The big risky project paid off. 😊 We're going to blow your socks off in like two years when we can get it published!
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@JohnStreicher1
John Streicher
2 years
I'm looking to recruit a non-tenure track faculty member to my lab. I see this as a mentored path to a tenure track position, where you will immediately start writing NIH grants as PI, in collaboration with me. DM/email me!
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@JohnStreicher1
John Streicher
1 year
@JoePostingg I'm imagining the best Dog The Bounty Hunter episode of all time
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@JohnStreicher1
John Streicher
9 months
Reviewer, *why* do you want to know how many mice total were used in the entire paper? What possible benefit does that provide you, apart from making me waste the time to count them all up?
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@JohnStreicher1
John Streicher
2 years
For the naysayers, here are some hard numbers. We all like data, right?
@NikOgryzko
Nik Ogryzko
2 years
The stats bear this out:
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@JohnStreicher1
John Streicher
1 year
@Kyle_Ireton Now let's think on if a very powerful scientist who is also Jewish with family in Israel can be tarred as an antisemite and terrorist for expressing basic empathy with Palestinians, what could possibly protect the rest of us who do the same?
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@JohnStreicher1
John Streicher
22 days
Turns out I had untreated ADHD for 40-some years. Pharmacology is amazing, ya'll
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@JohnStreicher1
John Streicher
9 months
@Hapless23 @GarbageApe 36 Lessons is just too many. I can't vote for that many Lessons
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@JohnStreicher1
John Streicher
1 year
@vanillaopinions I'm a professor so...
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@JohnStreicher1
John Streicher
2 years
FWIW most of our applicants and admitted students don’t have pubs or postbacs. Average GPA is ~3.4. I wonder how much of this perception is driven by a small number of elite programs? I didn’t get into those programs either 24 years ago.
@KYT_ThatsME
K. Taylor, PhD
2 years
If you had told me that I would need a post bacc (pre doc ??) and post doc in addition to a PhD I would have done something else. I got a masters first and did undergrad research but had 0 peer reviewed pubs when I applied. I doubt I’d get into grad school today.
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@JohnStreicher1
John Streicher
1 year
An important piece on normalizing bringing your children to conferences, written by my student Jessy. We can support working parents and make our conference spaces more accommodating!
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@JohnStreicher1
John Streicher
2 years
The pro-Sabatini accounts are really something. Do you actually think you're making your boy look *better* here? Well I guess you can't be too smart going to bat for an abuser. πŸ€·β€β™€οΈ
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@JohnStreicher1
John Streicher
2 years
12th percentile. πŸ˜‡
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@JohnStreicher1
John Streicher
2 years
Perceived selectivity and impact is THE overriding factor that drives journal perception. Public reviews and transparency et al are nice but do not address this basic issue. If eLife loses that perception of selectivity they'll become PLOS TWO. If they keep it they'll perpetuate
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@JohnStreicher1
John Streicher
9 months
I have some good β€œdon’ts” based on past candidates. Don’t get drunk at the poster session. Don’t make outrageous charges to your room. Don’t make creepy comments to female students. Don’t openly insult our program, the one you’re applying to
@ADiaz_PhD
Dr. Arnaldo DΓ­az
3 years
Grad School interviews are around the corner. Colleagues, let’s share some advice for all candidates interviewing this season. What’s your #1 piece of advice? @jenheemstra @phdgprotein86 @Shoba_Bio @NLundsteen @FromPhDtoLife
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@JohnStreicher1
John Streicher
18 days
@CartoonsHateHer Why would you clean the whole house and do laundry every single day? That's once a week territory. Looks like someone is marketing their fetish content (again)
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@JohnStreicher1
John Streicher
6 months
@edzitron You’re laughing. The Bored Ape-themed burger restaurant has shut down, and you’re laughing
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@JohnStreicher1
John Streicher
11 months
I’m not sure how well non-PI people understand this. A typical NIH grant cycle is 8 months, and that’s the fast version. I’m partway into year 3 of my R01s and I’m starting to get worried about having funding by the end of year 5. It’s slow!
@drugmonkeyblog
Drug Monkey
11 months
Because β€œadvance warning” and the getting of more grant money β€œASAP” are on similar timelines.
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@JohnStreicher1
John Streicher
1 year
Our most recent paper by the talented @KatherineAriz18 just went live! We show that AMPK in spinal CGRP neurons acts as an anti-opioid negative feedback loop, which can be disabled by Hsp90 inhibition. We made the cover!
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@JohnStreicher1
John Streicher
10 months
Data-free spicy hot take: I'll bet student equity and success would be enhanced by abolishing the F series and putting the money in R and maybe T. F awards aren't for training, they're career boosts for the already-succesful students from the most prominent labs
@kevinmawright
Dr. Kevin Wright
10 months
I am begging reviewers of trainee grants to do better. I understand it is competitive out there. But commenting on a 3rd year PhD student's UG grades when the applicant has As in every grad level course is lazy and irrelevant. If its not score driving, it shouldn't be there
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@JohnStreicher1
John Streicher
6 months
Congratulations to the newly minted Dr. Abby Schwarz! She did a fantastic job today defending her dissertation on the impact of terpenes on chronic pain. A very special day for us mentors too - my 7th graduating PhD student!
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@JohnStreicher1
John Streicher
1 year
PSA: A drug doesn't have to have nM affinity to matter. Proglumide is taken by actual people and has a Kd of 0.8 mM! Actual humans routinely take doses of some drugs approaching 1 gm!
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@JohnStreicher1
John Streicher
1 year
Bizarre that a research grade 3D printer with sub-micron resolution is the same cost as one (1) Abcam antibody
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@JohnStreicher1
John Streicher
2 years
For rampant sexual harassment you fucking shameless hack.
@bariweiss
Bari Weiss
2 years
David Sabatini is one of the most important scientists in the country. So why is he on unemployment? This story is about far, far more than the destruction of one person:
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@JohnStreicher1
John Streicher
5 months
@CantEverDie You just wait until they start Door Dashing IEDs into the combat zone
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@JohnStreicher1
John Streicher
9 months
Scienceℒ️
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@JohnStreicher1
John Streicher
4 years
One of the goofiest things we do in science is have PIs put on the lab coat they haven't worn in years, and pretend to do real work for publicity photos. Now it's my turn to look ridiculous!
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@JohnStreicher1
John Streicher
7 months
Accepted! (Finally!)
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@JohnStreicher1
John Streicher
6 months
@TeresaForNM Her career is a public trust with a duty of care to an entire nation full of people. It’s not all about her and her choices!
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@JohnStreicher1
John Streicher
2 months
TIM WALZ PASSES HIS GREATEST CHALLENGE YET! MENSWEAR GUY APPROVES HIS FIT!
@dieworkwear
derek guy
2 months
@JoeyMannarinoUS this is a good example of how anyone can look good if they buy clothes in their size
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@JohnStreicher1
John Streicher
8 months
@kaden53535 Great question. But I've got one first. Is any of this statistically significant given those big honkin error bars? You wouldn't be making politically convenient conclusions based on bad data would you?
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@JohnStreicher1
John Streicher
2 months
@RaceplayShawty You're shattering your movement into pieces by defending nazi rhetoric you dumb motherfucker
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@JohnStreicher1
John Streicher
1 year
Truly baffling to read this and then decide it's some vast indictment of academia. Why should anyone feel entitled to retain vast sums of scarce public research funds while they go do something else for a year? Do the work you took that money to do! NIH is being responsible here!
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@JohnStreicher1
John Streicher
5 months
@4everKentuckian She was there putting her body on the line and you weren't. What does that reveal?
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@JohnStreicher1
John Streicher
5 months
@mike_feigin NCBI has a very useful Design Primers tool that's attached to every sequence in the database. Very handy!
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@JohnStreicher1
John Streicher
24 days
Me when I'm asked how I'm going to get an R01 in an 8th percentile environment: "I have concepts of a plan!"
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@JohnStreicher1
John Streicher
2 years
Cell-based methods aren't ready and probably never will be. More people will be hurt if the FDA uses this new ability to forego animal testing - and companies will apply prodigious pressure for them to do so. They don't care if people are hurt, only $$$.
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@JohnStreicher1
John Streicher
1 year
My first postdoc is going up for tenure. I'm proud....and old! πŸ₯²
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John Streicher
2 months
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@JohnStreicher1
John Streicher
6 months
Alright, which one of you gave this guy an MD???
@KenDBerryMD
Ken D Berry MD
6 months
The Sun does not cause skin cancer. Skin cells built of inferior fats (omega-6 rich seed oils) are more susceptible to cancer & aging. Build your skin cells out of the animal fats they are meant to contain and play in the sun!
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John Streicher
3 years
My children don't watch TV. My children have also never sullied their feet with unclean earth. They absorb spiritual energy to live without consuming corrupt flesh. They are Ascended Elder Gods and are poised to render terrible judgment on the wicked. Not a coincidence.
@dr_musgrave
Dr Katie Musgrave
3 years
My 8 yr old is never given access to a mobile device. She has, however, read Narnia, Harry Potter, Through the Looking Glass, and countless other books. I don’t think this is a coincidence. #screentime #screensharmkids #booklover #developingbrains
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@JohnStreicher1
John Streicher
9 months
This dude sitting next to me in the coffee shop is telling his date how your body becomes acidic from your food which is what causes disease and my soul is cringing
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@JohnStreicher1
John Streicher
2 years
@mTOR_Leaks It’s amazing you can post that thinking it exonerates your hero. The report maintains he’s not credible, threatened lab members, tolerated and fostered sexual harassment, slept with a mentee, and more! At this point you might be more disgusting than he is.
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@JohnStreicher1
John Streicher
2 years
PSA: no one is obligated to secure a guilty verdict from a court of law before they publicly criticize a sex creep. Especially since the conduct was legal and will never go to court. All you're doing here is making life easier for a predator.
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@JohnStreicher1
John Streicher
2 years
THEY SENT IT OUT FOR REVIEW!!! 😳 Never gotten this far before...
@JohnStreicher1
John Streicher
2 years
I'm ready to be hurt again by PNAS.
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@JohnStreicher1
John Streicher
7 months
Hey academics, can we do politics now since we're being directly threatened? Or do you still want to pretend that if you ignore the political threat it will go away?
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@JohnStreicher1
John Streicher
1 year
Autoclaves are the McDonald's ice cream machine of the science world
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@JohnStreicher1
John Streicher
1 year
Man I can't even get my new drugs into the brain half the time, but apparently whole-ass bacteria have no such trouble 😑
@DWeissLab
DWeissLab
1 year
Bacteria in our BRAINS?? Surprisingly, we observe translocation of gut bacteria to the brain via the vagus nerve. This occurs in mice fed a high fat diet, or without dietary changes in mouse models of Alzheimer’s, Parkinson’s, and autism. 🧡
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@JohnStreicher1
John Streicher
2 months
@courktree Gotta love how a couple of leftist dudes showed up to completely prove your point for you
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@JohnStreicher1
John Streicher
1 year
My general advice for junior PIs is to always have a letter from at least one senior scholar on your grant promising to babysit you. They don't even need salary they can be a consultant. I did this for years and it often helped, never hurt.
@drdevangm
Devang Mehta πŸŒ±πŸ‘¨πŸ½β€πŸ”¬πŸ§¬
1 year
how do other #newPIs respond to reviews that say β€œthe grant requests a postdoc but the applicant is a new PI and has never supervised a postdoc.”? Like, how are we supposed to start supervising people if we don’t get the chance to hire them first anyways?
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@JohnStreicher1
John Streicher
2 years
@kevinmawright I could buy, like, 7 antibodies
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@JohnStreicher1
John Streicher
2 years
@DrAnneCarpenter noLife, where only talented and motivated postdocs are allowed to publish
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@JohnStreicher1
John Streicher
1 year
Who fucking cares?
@LBRolsky
L. Benjamin Rolsky
1 year
Why do so many of my academic colleagues on here use profanity in their tweets? Like in comedy, I'm not exactly sure what your f**k is bringing to the table.
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@JohnStreicher1
John Streicher
1 year
Ah peer review, never change "Why aren't you studying this in the brain?" Because all the data we showed you points to spinal cord "Why aren't you studying reward?" Because we're studying pain! "You didn't tell us how you'll handle the viruses" We aren't using viruses!
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@JohnStreicher1
John Streicher
1 month
@IwriteOK "We have video!" "Can we see it?" "...no."
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@JohnStreicher1
John Streicher
2 years
the basic problem they're trying to address. In one sense the critique isn't fair because no one journal can solve this problem. It's a widespread issue from all of us as individuals to the funders to our institutions. It will take huge collective action to solve. Even then we
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