I'm a biomedical scientist at the University of Arizona. I study opioid receptor signal transduction, with the goal of developing non-addictive pain drugs
Our paper on the efficacy and mechanism of Cannabis terpenes in chronic pain just went live! Led by the talented Abby Schwarz. We found they produce strong pain relief by activating the Adenosine A2a Receptor in spinal cord. Check it out!
@NiohBerg
I feel for her. No one should have to go through that. I also saw a Palestinian father carrying his dismembered child in a bag. Maybe we could do something about that??
Got notice from my PO today that one of my R01s will be funded. The wild thing is I don't even feel happy or thrilled. Just a profound sense of relief. I get to keep my job. I won't have to jeopardize the careers of all my students. What a weird system we've built for ourselves.
Let's be real folks. It's not PIs keeping postdocs from being paid $100k+. That salary plus fringe is HALF of a modular R01. Plus PI salary support and supplies then an entire R01 becomes the personal grant of one PD. Not sustainable. Funding levels must rise for this to happen.
Junior faculty watch their labs wither and die for a lack of a $250k/yr grant while these...people...line up to give a sex creep fired for misconduct $25m. Sick.
I am pleased to announce that last night at
@PershingSqFdn
scientific advisors dinner, we announced that we found a 50% funding partner for the new Sabatini lab.The new lab now has $5m of funding per year for five years. David is now making launch preparations for the lab. Allez!
I could write "Western blot" in my papers or I could write "we zapped proteins with force lightning to make them run through Science Jello, then zapped them sideways onto gun cotton, then soaked them in salty milk and glow-in-the-dark rabbit blood so we could see them" π€
@ProfBootyPhD
@shreyabasu003
"In entertainment news, Beyonce shocked the world with a surprise wedding to a mysterious figure only known as 'Mr Smeg.'"
Iβve been beating my head against the grant brick wall for years. I was marinating in pessimism and unsure if Iβd have a lab by this summer. Now in the space of a week Iβve gotten a 3rd and 4th percentile score on 2 R01s. I literally canβt believe it.
You know, we already have a big journal that will review everything you send it, makes no decisions on impact, and has a decent rep. It's PLOS ONE. Does everyone treat it like the future of science? No they treat it as a dump journal for stuff you can't get published elsewhere.
@lee_kovarsky
My feelings exactly. We professors have a special duty of care to our students. Labeling our students as terrorists is a gross violation of that duty
Unacceptable. For all the people promising to boycott eLife until they fired Mike Eisen, Iβll boycott eLife until they reverse this chilling rejection of academic freedom
I have been informed that I am being replaced as the Editor in Chief of
@eLife
for retweeting a
@TheOnion
piece that calls out indifference to the lives of Palestinian civilians.
We made it - we fucking made it
This is really going to happen
Holy shit
Dementia and Alzheimerβs is as good as cured as of Today
We are coming to rescue your microtubules - hang on just a few more months
Hang on to your loved ones - you must not let them slip away β€οΈβ€οΈβ€οΈ
@petersm_th
We were here first. The title goes back to the Middle Ages and was used to refer to scholars of the highest achievement e.g. Doctor Thomas Aquinas. The term wasn't common for medical professionals until the mid-1700s.
A tough pill to swallow:
PhDs have spent a decade in post-secondary education for a degree that is essentially meaningless in the business world.
It is completely valid to feel regret, anger, and/or despair about this. Don't let it paralyze you.
How absurd is this getting? 1,465 mice over 26 (!) figures just to get into a solid society journal. Even then weβre fighting tons of negative comments and requests for more. Weβve all gone insane
Just got the notice - promotion to full Professor. When I was younger I never would have thought I'd be here. It's only a long line of amazing trainees like
@Viva_LaVig
and
@_KatherinG18
that have made this day possible. Thank you all.
Science is a social ecosystem. It works because we all make it work. Predators might get money, but we can deny them a place in our ecosystem. Refuse to review his manuscripts. Deny him speaking slots. Refuse to work for or with him. We can stand up for our collective values.
Why is it callous as some of you say to express sympathy with the Palestinian people? The original Onion article is satirizing an actual event where a Palestinian man who had just lost 6 of his family was asked to condemn Hamas. Why does Eisen deserve your rage and boycott?
The Onion speaks with more courage, insight and moral clarity than the leaders of every academic institution put together. I wish there were a
@TheOnion
university.
Everyone should understand the way that our profession functions. Not sure why this tweet is making everyone so mad, but the numbers are reasonable, he's not lying or making them up. Knowledge is power
How much does a graduate student cost per year?
Salary: $35,793
Benefits + Tuition: $26,463
Supplies: $12,000
Travel: $3,000
Overhead: $42,491
Total: $119,747
See, this is why you need to be careful with your SciComm. There isnβt a flash of light, thereβs a puff of zinc atoms. But now thanks to this thereβs dozens of people in the comments talking about souls and the spark of life. Donβt do this people, the clicks arenβt worth it
I thought I knew shitty grant reviewers - then I started putting in more F30/F31 apps with my students. Holy shit it's a whole new world of absurdity. Apparently publishing ~10 papers a year as a mentor is a "sparse publication record"????? Not to mention the factual errors...
Can anyone explain why Prism βisnβt transparentβ when each test has the equations used to calculate it in the help text? The same standard math weβve been using for decades? Doesnβt seem that obscure.
"No one can get postdocs." "People are leaving academia." "New grads aren't going into postdocs anymore." Is there any data for these common assertions? Would like to see it, instead of going off of Twitter vibes.
This thread is an example of why scientists have a DUTY to be responsible with our work. I looked up the study. The effects are in the MILLIMOLAR range using in vitro assays for a chemical the authors themselves note is less than a mg in common exposure. Highly irresponsible.
Well I finally pissed off reactionary Twitter. David Sabatini did the trick. I welcome your hatred, it tells me Iβm on the right path. Defending an abuser is very on brand for you folks.
I'm looking to recruit a non-tenure track faculty member to my lab. I see this as a mentored path to a tenure track position, where you will immediately start writing NIH grants as PI, in collaboration with me. DM/email me!
Reviewer, *why* do you want to know how many mice total were used in the entire paper? What possible benefit does that provide you, apart from making me waste the time to count them all up?
@Kyle_Ireton
Now let's think on if a very powerful scientist who is also Jewish with family in Israel can be tarred as an antisemite and terrorist for expressing basic empathy with Palestinians, what could possibly protect the rest of us who do the same?
FWIW most of our applicants and admitted students donβt have pubs or postbacs. Average GPA is ~3.4. I wonder how much of this perception is driven by a small number of elite programs? I didnβt get into those programs either 24 years ago.
If you had told me that I would need a post bacc (pre doc ??) and post doc in addition to a PhD I would have done something else.
I got a masters first and did undergrad research but had 0 peer reviewed pubs when I applied. I doubt Iβd get into grad school today.
An important piece on normalizing bringing your children to conferences, written by my student Jessy. We can support working parents and make our conference spaces more accommodating!
The pro-Sabatini accounts are really something. Do you actually think you're making your boy look *better* here? Well I guess you can't be too smart going to bat for an abuser. π€·ββοΈ
Perceived selectivity and impact is THE overriding factor that drives journal perception. Public reviews and transparency et al are nice but do not address this basic issue. If eLife loses that perception of selectivity they'll become PLOS TWO. If they keep it they'll perpetuate
I have some good βdonβtsβ based on past candidates. Donβt get drunk at the poster session. Donβt make outrageous charges to your room. Donβt make creepy comments to female students. Donβt openly insult our program, the one youβre applying to
@CartoonsHateHer
Why would you clean the whole house and do laundry every single day? That's once a week territory. Looks like someone is marketing their fetish content (again)
Iβm not sure how well non-PI people understand this. A typical NIH grant cycle is 8 months, and thatβs the fast version. Iβm partway into year 3 of my R01s and Iβm starting to get worried about having funding by the end of year 5. Itβs slow!
Our most recent paper by the talented
@KatherineAriz18
just went live! We show that AMPK in spinal CGRP neurons acts as an anti-opioid negative feedback loop, which can be disabled by Hsp90 inhibition. We made the cover!
Data-free spicy hot take: I'll bet student equity and success would be enhanced by abolishing the F series and putting the money in R and maybe T. F awards aren't for training, they're career boosts for the already-succesful students from the most prominent labs
I am begging reviewers of trainee grants to do better. I understand it is competitive out there. But commenting on a 3rd year PhD student's UG grades when the applicant has As in every grad level course is lazy and irrelevant. If its not score driving, it shouldn't be there
Congratulations to the newly minted Dr. Abby Schwarz! She did a fantastic job today defending her dissertation on the impact of terpenes on chronic pain. A very special day for us mentors too - my 7th graduating PhD student!
PSA: A drug doesn't have to have nM affinity to matter. Proglumide is taken by actual people and has a Kd of 0.8 mM! Actual humans routinely take doses of some drugs approaching 1 gm!
David Sabatini is one of the most important scientists in the country. So why is he on unemployment? This story is about far, far more than the destruction of one person:
One of the goofiest things we do in science is have PIs put on the lab coat they haven't worn in years, and pretend to do real work for publicity photos. Now it's my turn to look ridiculous!
@kaden53535
Great question. But I've got one first. Is any of this statistically significant given those big honkin error bars? You wouldn't be making politically convenient conclusions based on bad data would you?
Truly baffling to read this and then decide it's some vast indictment of academia. Why should anyone feel entitled to retain vast sums of scarce public research funds while they go do something else for a year? Do the work you took that money to do! NIH is being responsible here!
Cell-based methods aren't ready and probably never will be. More people will be hurt if the FDA uses this new ability to forego animal testing - and companies will apply prodigious pressure for them to do so. They don't care if people are hurt, only $$$.
The Sun does not cause skin cancer.
Skin cells built of inferior fats (omega-6 rich seed oils) are more susceptible to cancer & aging.
Build your skin cells out of the animal fats they are meant to contain and play in the sun!
My children don't watch TV. My children have also never sullied their feet with unclean earth. They absorb spiritual energy to live without consuming corrupt flesh. They are Ascended Elder Gods and are poised to render terrible judgment on the wicked. Not a coincidence.
My 8 yr old is never given access to a mobile device.
She has, however, read Narnia, Harry Potter, Through the Looking Glass, and countless other books.
I donβt think this is a coincidence.
#screentime
#screensharmkids
#booklover
#developingbrains
This dude sitting next to me in the coffee shop is telling his date how your body becomes acidic from your food which is what causes disease and my soul is cringing
@mTOR_Leaks
Itβs amazing you can post that thinking it exonerates your hero. The report maintains heβs not credible, threatened lab members, tolerated and fostered sexual harassment, slept with a mentee, and more! At this point you might be more disgusting than he is.
PSA: no one is obligated to secure a guilty verdict from a court of law before they publicly criticize a sex creep. Especially since the conduct was legal and will never go to court. All you're doing here is making life easier for a predator.
Hey academics, can we do politics now since we're being directly threatened? Or do you still want to pretend that if you ignore the political threat it will go away?
Bacteria in our BRAINS??
Surprisingly, we observe translocation of gut bacteria to the brain via the vagus nerve. This occurs in mice fed a high fat diet, or without dietary changes in mouse models of Alzheimerβs, Parkinsonβs, and autism. π§΅
My general advice for junior PIs is to always have a letter from at least one senior scholar on your grant promising to babysit you. They don't even need salary they can be a consultant. I did this for years and it often helped, never hurt.
how do other
#newPIs
respond to reviews that say βthe grant requests a postdoc but the applicant is a new PI and has never supervised a postdoc.β?
Like, how are we supposed to start supervising people if we donβt get the chance to hire them first anyways?
Why do so many of my academic colleagues on here use profanity in their tweets?
Like in comedy, I'm not exactly sure what your f**k is bringing to the table.
Ah peer review, never change
"Why aren't you studying this in the brain?"
Because all the data we showed you points to spinal cord
"Why aren't you studying reward?"
Because we're studying pain!
"You didn't tell us how you'll handle the viruses"
We aren't using viruses!
the basic problem they're trying to address. In one sense the critique isn't fair because no one journal can solve this problem. It's a widespread issue from all of us as individuals to the funders to our institutions. It will take huge collective action to solve. Even then we