J Mark Sloan Profile Banner
J Mark Sloan Profile
J Mark Sloan

@Jmarksloan

3,039
Followers
3,006
Following
354
Media
1,616
Statuses

Factotum hematologist but esp AL Amyloidosis and HTLV associated ATLL. Assoc Prof and Heme/onc Program Director @The_BMC . The J is for jenius.

Boston MA
Joined July 2013
Don't wanna be here? Send us removal request.
Pinned Tweet
@Jmarksloan
J Mark Sloan
3 years
Every time I see a forest plot.
Tweet media one
3
7
58
@Jmarksloan
J Mark Sloan
3 years
Finding new holes punched in your patient’s belt is the single worst prognostic sign in all of oncology.
23
59
2K
@Jmarksloan
J Mark Sloan
5 years
Hematology findings in COVID-19 at admission (Guan NEJM): -lymphocytopenia (<1500) in 83.2% -thrombocytopenia in 36.2%, -leukopenia in 33.7%. Lymphocytopenia correlates w/ disease severity I highly recommend viewing Thursdays MGH grand rounds on COVID
8
283
538
@Jmarksloan
J Mark Sloan
2 months
Observation from a program director currently reading through hundreds of applications: you guys are killing me with the AI-generated personal statements.
26
16
318
@Jmarksloan
J Mark Sloan
2 months
These are my own but I suspect most program directors would feel the same.
Tweet media one
50
22
320
@Jmarksloan
J Mark Sloan
6 years
A less cynical reminder of why the work at #ASH18 is important #herosjourneyart
Tweet media one
1
121
253
@Jmarksloan
J Mark Sloan
4 years
@Davis_Hammet @MattNowak1 I don't understand the guns. Are they planning to shoot the virus?
11
6
195
@Jmarksloan
J Mark Sloan
4 years
BMW X5 with the Waldenstrom’s trim.
Tweet media one
6
22
207
@Jmarksloan
J Mark Sloan
4 years
I am grateful for the academic oncologists willing to refer their patients to another center for an appropriate clinical trial. This is unfortunately uncommon. It takes a village to study rare diseases and we must do this to move forward.
4
18
186
@Jmarksloan
J Mark Sloan
3 years
Delta flight to ASH Academics in the back Pharma peeps up front #ASH21 #ashhaiku
4
6
179
@Jmarksloan
J Mark Sloan
1 year
If you write a protocol for myeloma that requires 12 bone marrow biopsies in 5 years I’m going to assume that you no longer see patients.
Tweet media one
11
12
159
@Jmarksloan
J Mark Sloan
3 years
There are two guys in wheelchairs outside the front entrance of @The_BMC just hyping people up as they walk into the hospital and I love it.
2
1
142
@Jmarksloan
J Mark Sloan
5 years
I just finished reviewing the #COVID anticoagulation protocols at several different academic medical centers. Here is a summary. @connors_md @MaryCushmanMD @AggieLeeMD
Tweet media one
17
57
139
@Jmarksloan
J Mark Sloan
5 years
Before we run out of PPE, we should check serologies on all health care workers. Those who have already been exposed and have robust Ab responses but are no longer shedding virus can take over COVID care.
@choo_ek
Esther Choo, MD MPH
5 years
Italian physician Roberto Stella died - he continued caring for #COVID19 patients after running out of personal protective equipment, saying “We have run out of masks. But we don't stop. We are careful and we go on.” 1/
25
707
2K
7
19
131
@Jmarksloan
J Mark Sloan
2 years
Tip from a Heme/Onc Fellowship Program Director If you spent 1+ years as a hospitalist, I will ask: "What did you do to leave your hospital better than when you found it?" QI projects, Med student teaching, mentorship, moving forward a research project are all acceptable answers
2
13
108
@Jmarksloan
J Mark Sloan
5 years
With a little foresight, the vacant @The_BMC E Newton pavilion (w it’s 50+ ICU beds) could be made into the Boston COVID-19 hospital. Think of how this would help triage and isolation. @marty_walsh @MassGovernor @KateWalshCEO
Tweet media one
8
15
101
@Jmarksloan
J Mark Sloan
6 years
I’ve started using fabricated aphorisms to my point. Today I told a patient “It’s like my dad always said: make sure you buy a plunger before you need a plunger.” My father definitely never said that.
5
9
90
@Jmarksloan
J Mark Sloan
3 years
Can we all agree CDAs should NOT be needed just get a look at the schema and inclusion criteria of a pharma-sponsored trial? Involving a hospital lawyer just to look at basic trial information that should already be publicly available is an enormous waste of resources.
10
3
90
@Jmarksloan
J Mark Sloan
4 years
Carfilzomib-induced TTP is no joke.
Tweet media one
4
11
85
@Jmarksloan
J Mark Sloan
4 years
Every leukemia survivor owes their life to this extraordinary man. Pioneer of platelet transfusions and multi-agent chemotherapy. The reason our wards are no longer ‘abbatoirs’ is because of his work.
0
15
82
@Jmarksloan
J Mark Sloan
5 years
For the full @The_BMC experience, please use the restroom outside the emergency department.
@FLOTUS45
Melania Trump 45 Archived
5 years
Looking forward to visiting @The_BMC tomorrow w/ @SecAzar to learn more about the compassionate natal care & support given to mothers & babies w/ NAS. #BeBest
1K
2K
13K
3
7
74
@Jmarksloan
J Mark Sloan
2 years
You would think for a $730 registration and $375 membership fee @ASH_hematology could just let us watch the education spotlight videos from #ASH22 at our leisure.
Tweet media one
3
3
70
@Jmarksloan
J Mark Sloan
3 years
I don’t know who needs to hear this ( @SWOG ) but if you write a protocol that requires holding therapy for low ANC it makes it impossible to treat Duffy (a- b-) aka benign ethnic neutropenia patients. Result: black patients don’t go on trial or are taken off trial. Fix it.
1
6
71
@Jmarksloan
J Mark Sloan
3 years
I can’t even tell you guys how much I love these @BUHemeOncFellows . They got through this year with their shoulder to shoulder with their heads down but their eyes on the future. So proud.
Tweet media one
3
2
71
@Jmarksloan
J Mark Sloan
6 years
Its time for my yearly #ASH18 Summary! Drug A + Drug B has better PFS and more toxicity than drug B alone. Too early to see OS benefit but there probably is none. Dinner and Drinks by makers of Drug A at 8pm tonight at fancy restaurant C. Stop by the booth for free crap!
5
11
69
@Jmarksloan
J Mark Sloan
8 months
I was following someone for an IgG lambda MGUS for a few years before I noticed they were on Benlysta (belimumab) for SLE- a chimeric IgG lambda monoclonal. Not MGUS. The lesson is: Biologics don’t always appear on med list and aren’t obvious from their brand name.
5
9
65
@Jmarksloan
J Mark Sloan
2 years
@honeydewtown Meanwhile, This is a picture of professional baseball players in Japan showing up early for the game to clean outside the stadium.
Tweet media one
2
2
63
@Jmarksloan
J Mark Sloan
3 years
@AspiringERMD Life is long. How you feel at this moment will not be how you always feel; your struggles in 10 years will be much different. Find something (even if it is very small) each day that helps you believe you are doing meaningful work (which you are).
2
4
66
@Jmarksloan
J Mark Sloan
2 years
True story: New Orleans Shake Shack Employee: order for Jack 2!! Hematologist #1 : hehe. She said JAk2. Hematologist # 2: we need Jack, stat! #ASH22
1
4
66
@Jmarksloan
J Mark Sloan
4 years
What’s funny about academic medicine is that you’ll be doing your job and then when you are starting on service they will be like “here is a whole other job in addition to your job.”
4
2
64
@Jmarksloan
J Mark Sloan
4 years
25-50% of healthy people of african ancestry have ANC<1500 The term ‘Benign Ethnic Neutropenia’ implies non-whiteness is itself a disease. Create a .phrase for “typical neutrophil count w Fy(a-b-) status” @LaurenMerzMD @AchebeMaureen
2
13
64
@Jmarksloan
J Mark Sloan
4 years
Why do hospitals still have shared rooms? You can’t choose the lighting or the room temperature. Listening to your roommates TV, phone conversations, snoring and beeping IV is not healing. We pretend to value privacy but ignore this egregious violation.
4
0
59
@Jmarksloan
J Mark Sloan
3 years
Today I learned there is a drug called Imlifidase that completely degrades IgG for ~7 days. This could be used to temporize A LOT of problems in hematology. @jeanfrancis72
Tweet media one
Tweet media two
1
9
57
@Jmarksloan
J Mark Sloan
3 years
One of the @BUHemeOncFellows has an agreement with the man who hands out masks in the @The_BMC lobby to notify him by text whenever the morning Starbucks line shortens. Genius.
3
0
58
@Jmarksloan
J Mark Sloan
3 years
@ThaumaturgeRN @fuzzymittens Say this using a yoga puppet behind the anesthesia sheet as a makeshift theater for maximum impact.
1
0
54
@Jmarksloan
J Mark Sloan
5 years
I can’t be the only person eager to annotate those zany @EPICEMRparody hyperspace Log In screens.
Tweet media one
4
6
55
@Jmarksloan
J Mark Sloan
5 years
I ate a donut today from the nurses station even though I knew it was a bad idea. It wasn’t even good. I Can’t believe that’s how I’m going down. Idiot. #COVIDONUT
7
4
53
@Jmarksloan
J Mark Sloan
3 years
I’m going to give Evusheld to 10 patients before noon. So great to offer something to people unable to respond to vaccine.
1
0
52
@Jmarksloan
J Mark Sloan
6 years
The worst time to round on a patient is after they have poured the milk on their rice crispies but before they had a chance to eat them. Our team managed to hit this sweet spot in >50% of our service today.
0
5
50
@Jmarksloan
J Mark Sloan
1 year
Not all AL Amyloidosis should get dara-CyBorD. Rituxan is the cornerstone of tx for Waldenstroms Associated AL. You often need to look hard to find the LPL clone. BTK inhibs unexpectedly toxic in AL. Here is the @BU_Amyloidosis experience.
2
12
49
@Jmarksloan
J Mark Sloan
5 years
My strategy for this morning’s video conference: 1. Use a Mandalorian coffee mug to establish dominance 2. Rather than agree w a colleague, say “this is the way” 3. Proclaim “I have spoken” after every statement.
Tweet media one
2
0
49
@Jmarksloan
J Mark Sloan
3 years
International friends Help me get promoted! My faculty review committee tells me I need to give more international talks but that virtual talks will count. Invite me to talk at your grand rounds! I am best at talking about AL amyloidosis and Adult T Cell lymphoma leukemia.
6
9
47
@Jmarksloan
J Mark Sloan
3 years
Pool testing my entire family using a single BinaxNow swab is not my proudest moment.
6
0
45
@Jmarksloan
J Mark Sloan
6 years
Misspelling amyloid is no big deal. Misdiagnosing #amyloid , on the other hand, can be deadly. #spellingbee @Amyloidosis_BU •Ratio of MM pts to AL pts is 5:1. •renal biopsy for nephrotic syndrome has amyloid in 13% •10% of bilat carpal tunnel pts
Tweet media one
0
21
42
@Jmarksloan
J Mark Sloan
4 years
1894 Thanksgiving Meal @The_BMC . Not an IV in sight. I would have discharged everyone feeling well enough to get dressed and eat a full meal.
Tweet media one
1
1
42
@Jmarksloan
J Mark Sloan
1 month
Green flags in fellowship applications. Competitive programs have space to interview <10% of applicants so anything you want us to know needs to be conveyed in the application itself-- you can't wait for the interview to make a case for 'fit'.
Tweet media one
2
3
41
@Jmarksloan
J Mark Sloan
3 months
Shout out to my patient who just referred to getting daratumumab without premeds as ‘Raw-dogging it’
0
1
40
@Jmarksloan
J Mark Sloan
5 months
Applying for Heme/onc fellowship? Consider our four year program w @BUgeriatrics results in triple board eligibility. It is designed to create leaders in the growing field of geriatric oncology. @RZChipMD @MayaAbdallah_MD
0
8
37
@Jmarksloan
J Mark Sloan
3 years
@AaronGoodman33 Whoever named dabigatran pradaXa should be fired.
2
2
37
@Jmarksloan
J Mark Sloan
4 years
Hematologist: Hi! You've been diagnosed with smoldering multiple myeloma. Would you prefer to be over-treated or under-treated? Patient: Ummm. Neither? Hematologist: Great! Over-treatment it is. MRD here we come!
Tweet media one
2
4
36
@Jmarksloan
J Mark Sloan
2 years
Benefit of Vyxeos in secondary AML comes almost entirely from subgroup w DNTM3A and TET2 mutations. Didn’t help at all for TP53mut. Ven/aza inferior in TP53 Mut vs wt although good CR rate in poor risk cytogenetics w p53wt. Data from @ColemanLindsley & @DanPollyea #ASH22
Tweet media one
Tweet media two
2
8
36
@Jmarksloan
J Mark Sloan
5 months
Excited that @The_BMC was selected to be a part of this project. It is a first step towards improving outcomes in Duffy null persons. #DANC @LaurenMerzMD
@ASH_hematology
ASH
5 months
24 health & hospital systems have been selected to participate in the Absolute Neutrophil Count (ANC) by Duffy Status Project, supported by @DorisDukeFdn , which will redefine ANC reference ranges by Duffy status & address a critical health equity concern.
1
15
40
1
2
36
@Jmarksloan
J Mark Sloan
4 years
Hemophagocytosis is a common finding in lymph nodes and spleen on #COVID autopsies. These findings would often boost pre-mortem H-core into range consistent with HLH. Full preprint here: . @DitaGratzinger
Tweet media one
1
16
35
@Jmarksloan
J Mark Sloan
2 years
@joshmcgoo 1. Time alone w the patient is the greatest gift you can give a student. 2. You don’t need to try to teach with every breath. When you’re pinched for time make a single teaching point and then move on. 3. Show them that you enjoy and take pride in your work.
1
2
35
@Jmarksloan
J Mark Sloan
4 months
The 2023 @ASH_hematology guideline recommends thrombophilia testing for patients w/ pregnancy or contraceptive induced VTE and indefinite AC for those who test +. I wasn't testing or giving extended AC for clearly provoked events. @MiddeldorpS @connors_md @NTConnell
Tweet media one
3
6
34
@Jmarksloan
J Mark Sloan
3 years
We wrote this trial after growing tired of watching ATLL patients die. There were no front line studies available at the time. This shows that long term survival is possible. Early Brentuximab inclusion (even if CD30 negative) and PROMPT alloSCT critical. Still enrolling!
0
3
34
@Jmarksloan
J Mark Sloan
1 year
Heme/Onc Fellow applicants: @The_BMC has a unique 4 yr geriatric oncology program that leads to triple board eligibility. Graduates are doing amazing things. In ERAS as a separate app; it pulls from a smaller pool of applicants @RZChipMD
1
5
32
@Jmarksloan
J Mark Sloan
6 years
@drjessigold @sairarahman @choo_ek I was at an auction once where you could hire a bugler for several hours to play a fanfare whenever you entered a room or successfully printed an after visit summary.
1
0
34
@Jmarksloan
J Mark Sloan
5 years
Not that we need another thing to worry about, but I haven’t seen a new lymphoma referral in weeks. They’re not making their way through the system. Not good.
3
2
34
@Jmarksloan
J Mark Sloan
6 years
Dear ABIM, I do not order or interpret as many oxygen dissociation tests as you seem to think I should. Thanks for a fun day! Sincerely, A hematologist who will hopefully remain board certified.
1
5
33
@Jmarksloan
J Mark Sloan
2 years
Ven/aza Vs Vyxeos perform similarly as initial treatment in retrospective real world data. Transplant in CR1 critical. Data from @PratzKW #ASH22
Tweet media one
0
9
33
@Jmarksloan
J Mark Sloan
4 years
Several common eligibility criteria are really just surrogates for age exclusion. Does your trial REALLY need a GFR > 60? Clinical trials demographics should be representative. Thx to @sharon_inouye @paula_span for the reality check.
0
10
33
@Jmarksloan
J Mark Sloan
4 years
Me getting ready to discuss off label tocilizumab use in a COVID patient eligible for a clinical trial.
Tweet media one
1
2
32
@Jmarksloan
J Mark Sloan
2 years
@AaronGoodman33 6. Waiting for your CBC to come back so I actually have something to tell you.
0
2
33
@Jmarksloan
J Mark Sloan
6 years
Cassini study results as late breaking ASH abstract. Rivaroxaban effective for reducing cancer associated thrombosis in high risk patients while on threatment. Great work by @aakonc
Tweet media one
2
24
32
@Jmarksloan
J Mark Sloan
2 years
To everyone’s credit, this study (SWOG S1803) has been amended to accommodate appropriate dosing for the >50% of african American patients who are Duffy null.
Tweet media one
@Jmarksloan
J Mark Sloan
2 years
Another day another black patient unable to enroll on @SWOG S1803 (DRAMMATIC) because of their Duffy Null status. Minorities deserve fair representation on clinical trials. @DoctorAKrishnan @vsanchorawala
0
0
21
3
8
31
@Jmarksloan
J Mark Sloan
5 years
All elective procedures, stem cell transplants where timing isn’t critical, etc should be all postponed ASAP. Honestly the BEST thing that can happen is that months from now everyone will say we overreacted and hurt the hospital bottom line. That would be lovely.
0
5
32
@Jmarksloan
J Mark Sloan
5 years
The COVID vs acute chest differential in HbSS patients is my new least favorite thing. #SickleCell
5
2
31
@Jmarksloan
J Mark Sloan
4 years
I’ve Discussed this w many of the most knowledgeable Lymphoma docs in the US and literally nobody agrees w @nccn guidelines to give escalated BEACOPP for PET2+ patients. This guideline needs revisiting.
Tweet media one
6
8
31
@Jmarksloan
J Mark Sloan
4 years
I tried this metaphor in conference for @BUHemeOncFellows but nobody understood. I will therefore be including @TomBrady meme interpretation in my match selection criteria for next year. #TB12
Tweet media one
0
0
31
@Jmarksloan
J Mark Sloan
4 years
> 40% of black pts experience skin pigment changes on Revlimid. Changes occur early, are slow to resolve and can be distressing. This was underappreciated because pivotal trials done almost exclusively in white pts. @dhughesPharmD @vsanchorawala
3
4
31
@Jmarksloan
J Mark Sloan
5 years
Hey Matthew and Matthew’s dad! Thanks for supporting your mom while she works with us @The_BMC . We appreciate her. And good luck w the homework.
Tweet media one
0
0
31
@Jmarksloan
J Mark Sloan
6 years
In 9 years at my hospital, the only IT change that made my life better was when they increased my email storage quota. Everything else just resulted in more clicking to satisfy an administrator.
5
2
29
@Jmarksloan
J Mark Sloan
3 years
I strongly consider any fellowship candidate w a black belt for an interview because they would be useful in case there is a rumble with another program at the hematology meeting.
0
0
30
@Jmarksloan
J Mark Sloan
7 years
Message from @MorieGertz at #ISA2018 : If you’re a cardiologist, nephrologist or oncologist and haven’t Diagnosed #Amyloidosis , you aren’t doing a good job. •Ratio of MM pts to AL pts is 5:1. •renal biopsy for nephrotic syndrome amyloid in 13% •median 3 MDs seen before dx
3
26
29
@Jmarksloan
J Mark Sloan
5 years
@Toaster_Pastry If I’m not watching a video of this by tomorrow at 5pm I’m going to be PISSED.
1
0
27
@Jmarksloan
J Mark Sloan
6 months
The @livestrong fertility assistance program is a blessing for young patients undergoing chemotherapy. It's disappointing they will not extend the program to help preserve fertility in #SickleCell patients receiving gene therapy. @AllianceForFP @oncofertility @VertexPharma
5
10
27
@Jmarksloan
J Mark Sloan
5 years
We can do this, people. It’s not forever. I have so much faith in us. #bostonstrong
0
2
28
@Jmarksloan
J Mark Sloan
7 months
While we usually shrug it off as insignificant, the loss of the Y chromosome (mLOY) in men is associated with a much higher cancer mortality, CV mortality and all cause mortality than those without it. Possible association with ATTR amyloidosis. @BU_Amyloidosis
Tweet media one
1
5
26
@Jmarksloan
J Mark Sloan
3 years
Sickle cell trait is frequently blamed as a cause of death for black people who die while in custody. Thank you to @laforgia_ @jenvalentino for exposing this charade. #Hemetwitter has your back.
0
10
28
@Jmarksloan
J Mark Sloan
10 months
Accumulating data on sequencing of bispecific Abs and CAR-T. Summary: Still getting good responses, lower CR rates and lower DOR. Dont use same product. Good idea to switch antigens, be mindful of T cell exhaustion. #ASH23
Tweet media one
Tweet media two
Tweet media three
2
6
26
@Jmarksloan
J Mark Sloan
6 years
@OBGaYN NOBODY CARES WHAT THEIR DOCTORS STEP 1 SCORES WERE. Missing an entire year of medical school to cram for the boards is an absurd decision. Learn it, test it, forget it is a lousy educational strategy if the real goal is to be a good doctor.
0
1
25
@Jmarksloan
J Mark Sloan
5 years
Planning to write this protocol as a small ph2 @The_BMC this weekend. Does anyone have any thoughts or advice? Anyone know of something similar in existence? Any advice for getting an expedited IND? Thanks!
Tweet media one
4
6
27
@Jmarksloan
J Mark Sloan
5 years
I’ve never been more self conscious of my excercise-induced, cough-variant asthma than I was jogging this morning.
1
0
27
@Jmarksloan
J Mark Sloan
3 years
“He is unmatched as a candidate” is a poor choice of words for a fellowship letter of recommendation.
2
0
26
@Jmarksloan
J Mark Sloan
1 year
@dr_cellini Heme/onc Program director here. I hear you. But being a chief resident is the single most meaningful item on your fellowship application.
3
0
26
@Jmarksloan
J Mark Sloan
6 years
A Hickman catheter signifies a serious problem has occurred. New AML. Stem cell transplant. Access for dialysis. Yet it’s placement allows the work of healing to begin. I’m grateful to Dr Hickman for making my job possible. @skohoro
1
9
26
@Jmarksloan
J Mark Sloan
5 years
Vitamin C may restore TET2 function in #myelodysplasia . Worth trying in low risk MDS w/ TET2 mutation. Article by @iannisaifantis1 brought to my attention by @DavidSteensma .
Tweet media one
1
3
25
@Jmarksloan
J Mark Sloan
6 years
One secret to a sustainable academic career is to have enough roles that nobody ever knows where you are ‘supposed to be’ at a given moment. People assume I’m doing something important when I’m not in my office, which I am, but it often involves coaching a little league game.
1
1
24
@Jmarksloan
J Mark Sloan
4 years
For some reason we expect that the intelligent, talented people are also the kind people. In reality, these qualities exist on independent axes. Understanding this saves me some disappointment.
1
1
24
@Jmarksloan
J Mark Sloan
5 years
David Seldin has an ongoing presence in many lives through his scientific work and mentorship. Would that he were here to see our progress in #amyloidosis . @Amyloidosis_BU @The_BMC
Tweet media one
3
1
25
@Jmarksloan
J Mark Sloan
2 years
Love to see all the @BU_Amyloidosis @The_BMC trainees at #ISA_2022 Heidelberg 2022
0
3
25
@Jmarksloan
J Mark Sloan
3 years
Instead of calling it ‘RBC exchange for severe babesiosis’ we should call it ‘parasitapheresis’.
Tweet media one
1
5
25
@Jmarksloan
J Mark Sloan
5 years
There is no evidence to support therapeutic anticoagulation w/o overt thrombosis in COVID-19 DIC. Not sure why AC for pts above an arbitrary d-dimer threshold is showing up in hospital protocols. @connors_md @DrYukselUrun FAQ on COVID-19 coagulopathy.
Tweet media one
5
7
25
@Jmarksloan
J Mark Sloan
4 years
My 10 yo was showing me the best way to eat an Oreo and now I know what mansplaining feels like.
1
0
24
@Jmarksloan
J Mark Sloan
7 years
This is NOT a joke: Q: What do you get when you treat a patient who has ATTR + MGUS with plasma cell tx? A: Progressive ATTR + side effects from plasma cell therapy. Need TTR typing on all af/am pts and LC MS/MS in ambiguous cases.
@BWHAmyloid
BWH Amyloidosis Program
7 years
At @BWHAmyloid we have seen numerous patients with TTR who have received chemotherapy because they were misdiagnosed as AL amyloidosis. @rodney_falk @DorbalaSharmila @AvinainderSingh #Amyloidosis
3
7
15
3
14
25
@Jmarksloan
J Mark Sloan
4 years
Godspeed @BUMedicine class of 2020. Make me proud.
Tweet media one
0
0
24