Biotech Jim @JamesEKrause Twitter profile | Pikagi

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Biotech Jim

@JamesEKrause

11,084

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555

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phd biochem, not ichthyol; prof neurobiol, biotech entrepreneur, neurogeek, inventor, environmentalist focused on sustainability, also ERoEI. #neurosteroids

Wisconsin, USA

https://t.co/ISg8XxsBZb

Joined February 2019

Don't wanna be here? Send us removal request.

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@JamesEKrause

Biotech Jim

6 years

This new class of migraine drugs is a game changer for patients. Always loved the CGRP story in sensory neurons, similar to my favorite neuropeptide system, Substance P and the NK-1 receptor and family members. Going way back...

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Molecular characterization of a functional cDNA encoding the rat substance P receptor - PubMed

Substance P is a member of the tachykinin peptide family and participates in the regulation of diverse biological processes. The polymerase chain reaction and conventional library screening were used...

pubmed.ncbi.nlm.nih.gov

@semodough

dough

6 years

CS spoke with several physician experts in the headache/migraine field recently to get a better sense of how they have incorporated the new anti-CGRPs into their practices. They view the 3 approved agents $AMGN $NVS’ Aimovig, $TEVA Ajovy and $LLY Emgality) as roughly the same

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@JamesEKrause

Biotech Jim

3 years

@YossiGestetner @GuyGadboisGuyG1

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@JamesEKrause

Biotech Jim

10 months

For #biotech investing, I tend to rely solely on myself for due diligence and critical evaluation of biotech companies. But analyst reports can be of substantial help is assessing competition. Recently Stifel came out with a tome on the future of biotech and medical innovation,

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@JamesEKrause

Biotech Jim

4 years

PAV Medical $PAVM Upcoming Key Activities and Milestones, from bigpike on IVillage, from the earnings call...

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@JamesEKrause

Biotech Jim

8 months

It has been 5 yrs for me on X. Thanks to my followers and my network for providing #biotech investing ideas, discussion, and critical analysis. BTW, I bought my grandfather's homestead farm with biotech stock profits. We call it our cottage, a place for my extended family to

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@JamesEKrause

Biotech Jim

1 year

@RottenInDenmark @masterlongevity You would think he would want to learn about CNS tight junctions, and more.

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@JamesEKrause

Biotech Jim

4 years

Some may say that $FSDC is an undiscovered SPAC. My view is many keeping quiet. Figure sent to me from Nik Tzoumas from "Revisiting ,,,CFH in AMD", CFH mutations in impt complement disorders. Gemini Therapeutics approach is elegant, compelling. Long $FSDC.

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@JamesEKrause

Biotech Jim

3 years

Pres Biden in his Presser mentions $NVAX. C'mon man, at least give the stock symbol also!

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@JamesEKrause

Biotech Jim

7 months

I would not be surprised to see $REGN make a big splash in obesity with a $VKTX offer. Of course, many are checking out Viking very carefully. Plus, George and Lenny have an ongoing focus on Glp1-induced muscle loss, with an added bonus that they have a strategy for ligament and

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@JamesEKrause

Biotech Jim

10 months

Thanks very much Sanjit, what a great team you point out. Health and happiness to all going into year end. Bought this homestead estate (the farm as we call it) 👇 with stock profits from $AXSM, $MDGL, $VKTX and $ETNB. Always looking for the next multibaggers... Time now for

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@JamesEKrause

Biotech Jim

3 years

What are we teaching our kids these days? The beginnings of a math and physics education needs to start in grade school. Tip of the hat to my friend ScottMc...

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@JamesEKrause

Biotech Jim

3 years

$NVAX $MRNA $BNTX $PFE One slide summary from the NVAX's Dr Glenn at the WHO presentations today. Much better than booster data from MRNA.

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@JamesEKrause

Biotech Jim

8 months

$VKTX Conf Call just finished, CEO strongly speaks to the issue of the value of a liver targeted therapy for M(N)ASH. Best call of R&D progress I have heard from Viking in the many yrs I have been listening.

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@JamesEKrause

Biotech Jim

7 months

$TGTX Q CC summary 👇💪 Four priorities for 20241. 1. Make IV Briumvi more convenient via shorter initial infusion time 2. SubQ Briumvi development, a novel market (note that this glyoengineered Briumvi has the highest CD20 affinity of all CD20 branded agents, and this form

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@JamesEKrause

Biotech Jim

3 years

Simply a stunning photo. What an amazing physical world we live in.

@konstructivizm

Black Hole

@konstructivizm

3 years

Chicago and lake Michigan from space at night, with the aurora Borealis and the Milky Way by NASA

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@JamesEKrause

Biotech Jim

4 years

Caught on my friend Tim's trail cam this past week. You never know who can be lurking with the bobcats and coyotes.

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@JamesEKrause

Biotech Jim

5 years

#SGMO is the only genetic engineering biotech I own. At ISTH, $SGMO knocked the ball out of the park with its HemA data set, along with $PFE as collaborator.

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@JamesEKrause

Biotech Jim

4 years

From time to time I post on #fishing , my second most fav hobby after #biopharma and pioneering medical advances. Ice is on the lake and I have not put out the tip-ups yet, But my neighbor did. Nice early ice northern pike. Will not be pumping a biotech company at this time!

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@JamesEKrause

Biotech Jim

3 years

$REGN New all time high, printing in the low $680s. At current price of $682.38, it is a 75 bagger. But, I sold 90% of the buy in getting here, so not the sharpest tool.

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@JamesEKrause

Biotech Jim

6 months

$MDGL Now this is curious... Hat tip to American Association for the Study of Liver Diseases Celebrates Approval of Madrigal's MASH Therapy, Resmetirom A leak or what.

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@JamesEKrause

Biotech Jim

7 months

$CRVS On Corvus, slowly initiating a position. and would be interested in hearing the bear case on this company and management. I started my dd about a week ago now, and I am all 👂👂🦻🦻. Can mgmt do it again? I remember the early rituximab days, what a beast.

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@JamesEKrause

Biotech Jim

10 months

$MDGL presentation ystdy at Evercore, a few notes. As of yesterday, 73 days to a possible AdCom/PDUFA, and the FDA minimum is 55 days to inform the company if it is to happen. March 14 approval expected. Then 2 weeks to roll out drug. Scale up and medical teams fully employed.

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@JamesEKrause

Biotech Jim

7 months

Seems to me that the bears are getting a bit nervous. $TGTX rate of growth amongst MS patients vis a vis CD20 drug switchers is strong. Further, academic centers growth is important as neurology docs most often are thought leaders in newer treatment paradigms. They certainly

@semodough

dough

7 months

$TGTX - bears /shorts said 9 months ago we never get 10% capture rate - well after 1 year were there - I have more on switches later very encouraging trends - reviewing models now - after patent extension-longterm models getting increasingly bullish-standalone or M&A

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@JamesEKrause

Biotech Jim

4 years

$OCUL is a stock that many investors simply average up. Great executive leadership, huge markets, and buyout too soon is a sig opportunity. Been saying this is a must hold biotech for the past 18 months.

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@JamesEKrause

Biotech Jim

4 years

$OCUL Amazing that in Jan 2020 one could buy this company in the $4s. Ophthalmologic companies should continue to be solid 2021 investments. So true, as I have heard often, 'Nobody wants to go blind'. Esp if you hear it from anyone afflicted.

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@JamesEKrause

Biotech Jim

3 years

I continue to look for multibagger biotechs in a weak btech mkt, just wondering what might be multibagger nascent btech stocks. Looking for the next $REGN, but could handle a 5 bagger as well. One to 3 year time horizon. Thinking $HCAQ, $BFLY, $QSI. But new product companies?

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@JamesEKrause

Biotech Jim

11 months

$VKTX $MDGL $TERN On the VKTX 2 lead (NASH and obesity) cmpds patent situations, from Viking CEO Brian Liam on the Q CC call today, answering a Q by the Stifel Analyst A. Samimy. "Well, with the dual agonists, the IP estate was run beyond 2040. With the VK2809, the thyroid beta

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@JamesEKrause

Biotech Jim

6 months

$MDGL Great label, no biopsy needed. And the market opportunity... And we knew of close FDA interactions... “The Breakthrough Therapy designation for resmetirom reflects the FDA’s recognition of resmetirom's potential in the treatment of NASH as a

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@JamesEKrause

Biotech Jim

4 years

Three of my top 4 biotech positions, today. Time for harvesting long term cap gains is the game I am contemplating. You all know, tax planning. I will take the boat out to contemplate...

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@JamesEKrause

Biotech Jim

1 year

$MCRB I dipped my toe into the Seres Therapeutics #microbiome pond this morning. Good story, nice opportunity, a difficile treatment via other means.

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@JamesEKrause

Biotech Jim

3 years

To all $PAVM technicians, is this considered a nice breakout on good volume? Asking for the 20 or so friends that I recommended the stock to when it was hovering around a $ buck $ or so. 👊👊

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@JamesEKrause

Biotech Jim

1 year

Now is the time to buy $MDGL, like I did on $REGN in 2004. My day did that with Pentair Corp, ( $PNR ) a diversified mfg company in the upper mid-west USA in the 1970s when it went public. All multi-baggers and could be life changing if one does LTBH. Look at the historical

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@JamesEKrause

Biotech Jim

4 years

I have done this before, but will do it again. Thanks to all the health care workers worldwide, and the broad biopharmaceutical industry, for ALL their efforts to show that science and care for mankind leads today. Proud to be just a small part of the scientific enterprise.

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@JamesEKrause

Biotech Jim

3 years

Went trout fishing ystdy and caught this nice German brown trout. 17 1/2 inches on an inland stream.

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@JamesEKrause

Biotech Jim

4 years

I added $AXGT. This is not the Alzheimer's Disease drug company anymore (Dr Hung's efforts in the past). Transformed into gene therapy, and intriguing Parkinsons's Diesease efficacy seen to date. FWIW, Greg Stewart came out of our Neuroscience Training Program at #WUMS .

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@JamesEKrause

Biotech Jim

5 years

Absolutely spectacular.

@AvatarDomy

Domenico

5 years

“Firefall” at Horsetail Fall in Yosemite National Park, California, looks like a scene from a fantasy movie. But, it is an ordinary waterfall, which is illuminated by the sunset, that gives it a fiery glow.

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@JamesEKrause

Biotech Jim

3 years

Continuing DD on $CMRX, in press pub on ONC201, collab between NIH lab of dopamine expert D SIbley and Chimerix. High quality pub in the Mol Pharm, rigorous molecular pharmacology journal. Very interesting molecule and onc efforts. GPCR geeks take heed.

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@JamesEKrause

Biotech Jim

4 years

$PAVM, still holding all my stock from late 2019. Letting the story play out...

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@JamesEKrause

Biotech Jim

10 months

$MDGL $AXSM $TERN $BHVN $APLS $TGTX et al Two month chart of 12 biotechs, 10 of which are in my biotech basket at present. My goal is to hold for the long term, while diligence is non stop, FWIW. Please do your own due diligence, and be careful out there.

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@JamesEKrause

Biotech Jim

6 months

I have a stock discussion group with several friends, and here is a list of many of our holdings. Not #biotech stocks, but many have had exceptional 1 yr charts. $PDSB is a biotech stock, but they came up with this one as a buy. Always good to have some stocks beyond my biotech

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@JamesEKrause

Biotech Jim

4 years

#ALL is a terrible type of cancer, and I have been watching $AUTL for a while. Since the follow on has now closed (at $7/sh), time to buy. Initiated position today. Slides that helped convince me.

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@JamesEKrause

Biotech Jim

3 years

Went out fishing this morning, not a whole lot of action but did catch five fish. Beautiful sunrise this morning. Very peaceful.

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@JamesEKrause

Biotech Jim

7 months

Spectacular ongoing run by $OCUL. Kicking myself for not loading up more when my son asked if we should add. On the 2 month chart, approaching a double. Congrats to Jimmy S for his position, if you know what I mean. Please do your own due diligence, and be careful out there.

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@JamesEKrause

Biotech Jim

4 years

$PAVM CEO Lishan Aklog, 7500 shares, Form 4 filing, time stamp 10K WIZARD 12:07 PM ET 3/19/2021

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@JamesEKrause

Biotech Jim

3 years

Instead of closely watching biotechs and the market this morning, I set up my #fishing tipups and watchingfrom my office. Caught this healthy 26" northern pike, then released her. Looking for one much larger.

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@JamesEKrause

Biotech Jim

3 years

No longer a bagholder in Trillium Therapeutics, as $PFE to buy $TRIL. Sure happy I did not sell as a tax loss.

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@JamesEKrause

Biotech Jim

1 year

#NASHville stocks $MDGL, $VKTX, $TERN, $ETNB and $AKRO took a beating today after a strong run, and I picked up a few tranches of $TERN. Watch out for falling knives. IF the weakness was due to the $LLY triple agonist Glp1/GIP/Gluc peptide clinical data, I wonder how many know

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@JamesEKrause

Biotech Jim

1 year

$MDGL Madrigal Pharmaceuticals Announces Rolling Submission of New Drug Application to U.S. FDA Seeking Accelerated Approval of Resmetirom for the Treatment of NASH with Liver Fibrosis

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@JamesEKrause

Biotech Jim

4 years

Interesting model of CD47 bioactivity, a must read #thread for holders of $TRIL.

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@JamesEKrause

Biotech Jim

1 year

My best looking cantaloupe of the season, full slip picked today. Overlooking the lake and celebrating with a q6oz Coronado brewing co IPA. Solid harvest today. Carrots, Detroit big red beets, picking cukes, red potatoes, and even more raspberries. Made rasp freezer jam ystdy.

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@JamesEKrause

Biotech Jim

7 months

Just finished with the replay of $TGTX conf call. Lots of nuggets. If followers want, I can write up a summary of call highlights.

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@JamesEKrause

Biotech Jim

6 months

One hundred forty-one years ago my Maternal Grandfather was born. Joseph Hoinacki of Berlin, Green Lake County, Wisconsin was born on March 17, 1883. And today, I will toast the man who in 1900 had finished building his house and barn on the homestead. Not bad for a 17 yr old.

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@JamesEKrause

Biotech Jim

2 years

A basket approach to biotechs works well, several strong holds here, and a few nice opps. $REGN $MDGL $ETNB $RVNC $CNCE $VKTX $AKRO $LQDA $RLMD $AXSM $ITCI $KRTX

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@JamesEKrause

Biotech Jim

4 years

Did your ever see a million point elk?

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@JamesEKrause

Biotech Jim

10 months

$PFE $TERN $LLY $NVO $VKTX Pfizer Announces Topline Phase 2b Results of Oral GLP-1R Agonist, Danuglipron, in Adults with Obesity Friday, December 01, 2023 - 06:45am Back to the drawing board, but there is a need to look at all small molecule Glp1 agonist chemical matter in this

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@JamesEKrause

Biotech Jim

4 years

Impressive roll cloud over Lake Michigan, if you have ever seen one of these while out in a boat, they are scary. Set anchor and wait it out.

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@JamesEKrause

Biotech Jim

4 years

Life of a biotech stock LTBH'er...

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@JamesEKrause

Biotech Jim

4 years

$PAVM, PAV Medical is waking up, this year long hold + has been testing my patience. But I would have to go into a dresser drawer to find those stock certificates. Remember those days?

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@JamesEKrause

Biotech Jim

3 years

Raspberry jelly I prepared from my fall bearing Polana var plants. Took 10 qts fresh berries, juiced then (who likes the seeds?), and prepped intensely flavored Raspberry Jelly! About 10 pints. Great with vanilla custard, ice cream, et al.

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@JamesEKrause

Biotech Jim

6 months

$AXSM, my second largest biotech holding. This is an amazing data set, lots to digest here. Conf call at 8am EST.

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@JamesEKrause

Biotech Jim

4 years

$TRIL Not having been a long term holder, I am having a difficult time not trading for decent profits. But the more I read the CD47 scientific/clinical literature, I just sit on my hands.

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@JamesEKrause

Biotech Jim

4 years

#SARSCoV2 #COVID19 $IFRX $OMER $CCXI Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2- mediated complement over-activation, Figs 2.6 self explanatory, 3rd is C5a blood levels in COVID-19 pts

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@JamesEKrause

Biotech Jim

2 years

$MDGL Big Pharma is salivating at this #NASH opportunity. A lesson in clinical development, to be sure. Today was spent speaking with the 'tutes and analysts. Long day ahead, as per Paul on the CC.

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@JamesEKrause

Biotech Jim

3 years

In way of disclosure, I sold ~10% of my $NVAX trading shares today. Just trying to be straightforward about this. I have not sold any $MDGL or $GMTX, in fact I added to Gemini this morning. Just finished installing an invasive carp spawning barrier with my buds ystdy.

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@JamesEKrause

Biotech Jim

3 years

$PAVM 8K filing: On Aug 10, 2021, Co. issued a PR announcing that its majority owned subsidiary Lucid Diagnostics Inc. (“Lucid”) had begun testing patients referred by primary care physicians at three Lucid Test Centers in the Phoenix metro...

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@JamesEKrause

Biotech Jim

2 years

#NASH biotech stock action past 2 months. Extremely strong subsector. $MDGL $VKTX $AKRO $ETNB $TERN $GNFT $NGM $MIRM $ICPT $CBAY $IVA $HEPA

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@JamesEKrause

Biotech Jim

3 years

$NVAX Novavax Announces Initial Omicron Cross-Reactivity Data from COVID-19 Vaccine Booster and Adolescent Studies Stunning data, esp with omicron.

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@JamesEKrause

Biotech Jim

3 years

Just parking these US Army medals as a reminder that I live in the free world. Thanks, Colonel.

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@JamesEKrause

Biotech Jim

2 years

$MDGL $VKTX $ETNB $REGN et al my grad school/med school hormone biochem classes have given me confidence to buy certain biotechs, so I would def say that "education pays".

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@JamesEKrause

Biotech Jim

7 months

I decided to add some $VKTX below the follow on offering price this morning during its weakness. In the $84s, 3 small tranches. FWIW, and please do your own DD.

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@JamesEKrause

Biotech Jim

3 years

Despite what Mr Cramer had to say on the boob tube this morning.

@Guruleaks1

GuruLeaks

3 years

Jim Cramer on Elizabeth Holmes 2015... "To me, it's reasonable to compare you to Steve Jobs and what he did for computing" "I regard you as a visionary, next-generation person" @JimCramer @EHolmes2003 @Theranos April 2015 BOOYAH! @CNBC

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@JamesEKrause

Biotech Jim

2 years

Have a great weekend everyone. Incredible NASA composite photo from outer space looks at Chicago/Lake Michigan at night. The Aurora Borealis and tMilky Way form this unparalleled skyline. Southern part of Lake Michigan is evident with Chicago on its left side.

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@JamesEKrause

Biotech Jim

2 years

This is an incredible video, very difficult to witness.

@wonderofscience

Wonder of Science

@wonderofscience

2 years

Rare footage of a moose shedding both its antlers captured with a drone in a forest in New Brunswick. Credit: Derek Burgoyne

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@JamesEKrause

Biotech Jim

5 years

@SebGorka @pawcio2009 @realDonaldTrump I lived next door to Lewis Lynch, Tuskegee Airman, and man of kindness and wisdom, RIP Lew, I consider you one of my heroes.

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@JamesEKrause

Biotech Jim

1 year

Reuters Exclusive: WHO to consider adding obesity drugs to 'essential' medicines list $LLY $NVO $VKTX et al

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@JamesEKrause

Biotech Jim

1 year

@WallStreetSilv

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@JamesEKrause

Biotech Jim

5 years

Due solely a few astute folks here on $TWTR and a fund mgr, I found $OCUL. Thanks for this due diligence tip, I am really starting to like their chances. Been in $REGN for years, could be similar story here with focused pipe.

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@JamesEKrause

Biotech Jim

5 months

$VKTX Nice Q call ystdy, impt to see FDA feedback into each program. Added to my Viking position today, fwiw. Found the selective androgen receptor mothballed program (minimally stated) thoughts of interest. Fat loss, weight loss, muscle loss, interesting times for these

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@JamesEKrause

Biotech Jim

4 years

$ONCT Thanks @avidresearch for the pointer, did a quick DD this am and started a position.

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@JamesEKrause

Biotech Jim

2 years

Wishing all my followers Happy Holidays, and the best of health in the New Year. It has been a great stock market year for me, when the indices are down so much.

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@JamesEKrause

Biotech Jim

3 years

Ystdy the Madison WI Yahara Fishing Club held its 24th Annual Kids Ice Fishing Day on Lake Monona. ~350 kids showed up for free #fishing gear, hot chocolate, lunch, ice safety, fishing lessons and fun on the ice. Huge success.

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@JamesEKrause

Biotech Jim

4 years

Caramel apple pie made with my Lodi apples.

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@JamesEKrause

Biotech Jim

2 years

Check out the girth on this northern pike...

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@JamesEKrause

Biotech Jim

4 years

$IPHA $IFRX $OMER Scientists at $IPHA have preprint, unreviewed, submitted to Nature: "Identification of immune checkpoints in #COVID19 ". PDF download is here: I had a chance to review ystdy, and wanted to highlight certain findings and figures attached:

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@JamesEKrause

Biotech Jim

8 months

$TGTX, added to my modest position. FWIW.

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@JamesEKrause

Biotech Jim

3 years

Re-initated a position in $TGTX on the MS news discussion this morning. Dr Steinman knows MS, and the data is more than solid.

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@JamesEKrause

Biotech Jim

4 years

Let us not forget, both the health care workers and the scientists making a real difference, in this #coronavirus pandemic. I am so proud of both sets of heroes, and I have been with both.

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@JamesEKrause

Biotech Jim

3 years

$PDSB Worked the garden ystdy, so missed a lot of the fun. Just listened to post-ASCO conf call. Slide👇from the triple combo, a followup of pts, knocked my socks off. Analogy: trial predictive of registrational trial success, like my 2 wk sweet corn predictive of nice harvest.

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@JamesEKrause

Biotech Jim

3 years

As seen on several social media platforms I am told...

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@JamesEKrause

Biotech Jim

4 years

Happy Veteran's day to all. Especially to the Veterans. My father helped out, but rarely spoke about WW2. The few times he did, it was quite difficult for him.

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@JamesEKrause

Biotech Jim

4 years

Pitching biotech stocks on Twitter reminds me of the following joke about 'The talking dog'.

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@JamesEKrause

Biotech Jim

4 years

Added another tranche of $AXGT. A friend contacted IR about enrolling a relative in a #Parky clintrial, and the company was quickly responsive with impt info.

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@JamesEKrause

Biotech Jim

2 years

Congrats to all the $MDGL longs, it has been a heck of a ride. And a big thanks to the $MDGL team, of course the Paul and Becky show. Most of my shares were purchased just after the reverse merger, you know, LTBH.

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@JamesEKrause

Biotech Jim

4 years

$FSDC Merger with Gemini Therapeutics approved. Form 8-K FS Development Corp. For: Feb 03 10K WIZARD 2:20 PM ET 2/3/2021

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@JamesEKrause

Biotech Jim

4 years

Past week I continued to add to my $AXGT position, 3 GT programs with unmet need, especially the devastating #ParkinsonsDisease . $160M market cap! Exceptional Parky data to date.

@semodough

dough

4 years

current mixed-to-negative sentiment and undemanding valuation. LR chart below shows just how cheap $AXGT Mcap is compared to other gene therapies 😳😳

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@JamesEKrause

Biotech Jim

9 months

Many yrs ago I had a mentor who boldly stated 'plan your life and career in 10 year epochs". Sheesh I said, I am mostly concerned about the next few months, with grants, experiments, working with friends in the lab. But Professor Cowan, a neuroscience leader, was correct. It is

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@JamesEKrause

Biotech Jim

4 years

$NVAX, added ystdy. Best vaccine to date IMHO. Also, multivalent vaccines are us.

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@JamesEKrause

Biotech Jim

4 years

$AXGT Axovant Gene Therapies Strengthens Board of Directors and Announces New Chief Commercial Officer

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@JamesEKrause

Biotech Jim

2 years

$AXSM Medicare Part D Formulary changes. Hat tip to MG for this. HMO and HMO-POS Revisions

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@JamesEKrause

Biotech Jim

4 years

$OCUL Thanking CEO Antony Mattessich and team for a very solid Q. Lots going on there, why would I sell my LTBH shares now? $NVS was a great training ground for Antony!

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