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Charles Herndon

@DrCycloPath

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Student fellow @PennPathLabMed Pathology notes 09/29/2024 All views are my own #PediPath #BSTPath #HemePath #PathTwitter #Pathology

Philadelphia, PA
Joined April 2023
Don't wanna be here? Send us removal request.
@DrCycloPath
Charles Herndon
7 months
Please help, I've given everything to become a pathologist, but I did not match. 4 programs remain unfilled. #PathTwitter #PathResidents #PathMatch2024
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@DrCycloPath
Charles Herndon
2 months
____ of the retroperitoneum shows ___ 🧬 alterations a) Desmoid fibromatosis b) Inflammatory myofibroblastic tumor c) Low-grade fibromyxoid sarcoma #BSTPath #PathTwitter #Pathology #GIPath 🔬 ↘️↘️↘️Pathology Case Challenge @Pathologists
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@DrCycloPath
Charles Herndon
2 months
Central stellate scar of ___ a) clear cell RCC b) chromophobe RCC c) oncocytoma #GUPath #Pathology #PathTwitter
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@DrCycloPath
Charles Herndon
11 months
Acute Leukemia = more than 20% blasts or which translocation? A) inv(16) / CBFB-MYH11 B) t(15;17) / PML-RARA C) t(8;21) / RUNX1-RUNX1T1 D) All of the above #hemepath #pathtwitter #pathology #pathresidents 🖼️©️ @LadyJayDoc @LucasMassoth @ghayda_basfar @jake_Bledsoe @DavidSteensma
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@DrCycloPath
Charles Herndon
9 months
No online pathology education resource compares to @UMichPath 's virtual slidebox. The free platform provides 🔬WSIs + IHC for every disease. It is no longer available. I hope security & policy changes are reconsidered to keep @UMichPath 's educational influence secure #PathTwitter
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@DrCycloPath
Charles Herndon
10 months
Paraspinal mass, (-) neuroendocrine markers A) Neuroendocrine Tumor (misbehaving with IHC) B) Something Else #BSTPath #Pathology #PathResidents #Pathologists #DermPath #NeuroPath #PathTwitter #PathX
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@DrCycloPath
Charles Herndon
1 month
"Avatar" brain. Cause? A) Carbon monoxide poisoning B) Methanol poisoning C) Cyanide poisoning D) Iatrogenic #Neuropathology #Forensics #pathology #pathologists #PathTwitter
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@DrCycloPath
Charles Herndon
8 months
Stomach, ___ -type adenoma. A) foveolar B) intestinal #GIPath #PathResidents #PathTwitter
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@DrCycloPath
Charles Herndon
10 months
This🍳 glioma is defined by: A) IDH mutation B) 1p19q codeletion C) All of the above #neuropath #molpath #pathresidents #pathtwitter
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@DrCycloPath
Charles Herndon
7 months
Lung. Diagnosis? A) Atypical Adenomatous Hyperplasia B) Adenocarcinoma in situ C) Minimally Invasive Adenocarcinoma #pulmpath #pathtwitter #pathresidents
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@DrCycloPath
Charles Herndon
1 month
Salivary ___ carcinoma is defined by rearrangements of ETV6 A) secretory B) acinic cell C) duct #PathTwitter #Pathology #ENTPath #PediPath
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@DrCycloPath
Charles Herndon
1 month
Intranodal ___ affecting an inguinal lymph node A) schwannoma B) hyalinizing spindle cell tumor with giant rosettes C) palisaded myofibroblastoma 🔬 #BSTPath #PathTwitter #Pathology #HemePath
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@DrCycloPath
Charles Herndon
2 months
65F, mass in the tail of pancreas, diagnosis? a) serous cystadenoma b) mucinous cystic neoplasm c) pancreatic pseudocysts #GIPath #Pathology #PathTwitter Photo🙏 @OlcaBasturk
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@DrCycloPath
Charles Herndon
8 months
Pattern of lung injury? A) Usual interstitial pneumonia (UIP) B) Diffuse alveolar damage (DAD) C) Organizing pneumonia (OP) #PulmPath #PathResidents #PathTwitter
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@DrCycloPath
Charles Herndon
11 months
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@DrCycloPath
Charles Herndon
3 months
Blasts with cup-like indentations are seen in AML with a) NPM1 mutation b) CBFB::MYH11 fusion c) PML::RARA fusion d) RBM15::MRTFA fusion #HemePath #PathTwitter #pathology
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@DrCycloPath
Charles Herndon
5 months
5yo boy with bowel intussusception due to ____ A) lymphoma B) bowel reduplication C) meckels diverticulum #GIPath #PediPath #PathTwitter #pathology 🙏🖼️ @WebPathology
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@DrCycloPath
Charles Herndon
10 months
Staghorn 🦌Vessel Differential: A) Solitary Fibrous Tumor (SFT) B) Monophasic Synovial Sarcoma (MSS) C) Mesenchymal Chondrosarcoma (MCS) D) Pleomorphic Hyalinizing Angiectatic Tumor (PHAT) 🔬 #BSTPath #PathTwitter #PathResidents #Pathology
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@DrCycloPath
Charles Herndon
7 months
___ 🧬 alterations are more often seen in invasive encapsulated follicular variant PTC A) RAS B) BRAF C) GLIS D) RET #PathTwiter #PathResidents #ENTPath #EndoPath #Thyroid
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@DrCycloPath
Charles Herndon
6 months
Pancreatic mass. Diagnosis? A) Non-diagnostic B) Negative (for malignancy) C) Neoplastic (benign or other) D) Malignant #cytopath #pathology #gipath #pathtwitter
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@DrCycloPath
Charles Herndon
4 months
A 10 yo XO girl with malabsorption, diagnosis? A) Whipple disease B) Lymphangiectasia C) Lymphangioma #GIPath #BSTPath #pedipath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
3 months
_____ esophagitis a) Eosinophilic b) Reflux c) Sloughing #GIPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
2 months
____ Castleman disease increases the risk of developing ____ sarcoma a) Multicentric b) Hyaline vascular #HemePath #BSTPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
1 month
Axillary mass in an 11-month-old, diagnosis? A) Fibrous Hamartoma of Infancy B) Lipofibromatosis C) Lipoblastoma D) Infantile Myofibromatosis #PediPath #BSTPath #DermPath #PathTwitter #Pathology 🔬
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@DrCycloPath
Charles Herndon
4 months
20yo testis, diagnosis? a) embryonal carcinoma b) seminoma c) choriocarcinoma d) granulosa cell tumor #PediPath #GUPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
2 months
⚠️ ___ contains giraffic content 🦒 a) trichilemmoma b) cylindroma c) basal cell carcinoma #DermPath #PathTwitter #pathology #BSTPath 🔬
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@DrCycloPath
Charles Herndon
3 months
Fallopian tube. Diagnosis? A) Adenomyosis B) Atypical Polypoid Adenomyoma (APA) C) Adenomatoid Tumor D) Adenofibroma #GynPath #BSTPath #PathResidents #PathTwitter
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@DrCycloPath
Charles Herndon
1 year
Fall begins today! So when you see leaves, think of Giardia! If you see Giardia in a kid, rule out an immunodeficiency. Any signs of immunodeficiency on this H&E?? #GIPath #HemePath #PediPath #PathMatch2024 #PathResidents #PathX #PathBugs 📝
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@DrCycloPath
Charles Herndon
4 months
___ variant PTC's key diagnostic feature is ___ a) Columnar cell b) Tall cell c) Cribriform morular #Pathology #PathTwitter #Thyroid #EndoPath #ENTPath
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@DrCycloPath
Charles Herndon
1 month
Sinonasal ___ in a 15♂️ with recurrent epistaxis A) glomangiopericytoma B) angiofibroma C) inflammatory polyp D) mucosa (normal) 🔬 #ENTPath #PediPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
8 months
Uterus. A) Adenomyosis B) Atypical Polypoid Adenomyoma (APA) C) Adenomatoid Tumor D) Adenofibroma #GynPath #BSTPath #PathResidents #PathTwitter
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@DrCycloPath
Charles Herndon
9 months
Differential for Low-Grade Myxoid Lesions: A) Fibromyxoid Sarcoma B) Myxofibrosarcoma C) Myxoid Liposarcoma D) Cellular Myxoma #BSTPath #Pathology #PathTwitter #PathResidents 🔬
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@DrCycloPath
Charles Herndon
6 months
Adult lobectomy. Diagnosis? A) Pleuropulmonary blastoma B) Pulmonary blastoma C) Low grade fetal adenocarcinoma #pulmpath #pathresidents #pathresidents #pedipath 🔬
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@DrCycloPath
Charles Herndon
3 months
Pancreatic ___ neoplasm a) neuroendocrine b) solid pseudopapillary #GIPath #CytoPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
9 months
Micropapillary lung adenocarcinoma shows a ____ pattern A) single-cell B) filigree C) ring-like D) A, B, or C #pulmpath #pathtwitter #pathresidents
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@DrCycloPath
Charles Herndon
5 months
Spindle cells in a sigmoid polyp. Diagnosis? A) Perineurioma B) Schwannoma C) Schwann cell hamartoma D) Ganglioneuroma #GIPath #BSTPath #PathTwitter #pathology
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@DrCycloPath
Charles Herndon
8 months
Lung, prominent nucleoli, no 🧂 & 🌶️ Next step in diagnosis? #PulmPath #BSTPath #Pathology #PathTwitter #PathResidents
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@DrCycloPath
Charles Herndon
2 months
Megakaryocytes with staghorn nuclei 🦌are characteristically seen in ____ a) polycythemia vera b) essential thrombocythemia c) chronic myeloid leukemia d) primary myelofibrosis #HemePath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
1 month
45F never smoker, solitary pulmonary lesion. Diagnosis? A) Sclerosing pneumocytoma B) Carcinoid tumor C) Solitary fibrous tumor #PathTwitter #pathology #pulmpath #thoracic #pedipath
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@DrCycloPath
Charles Herndon
10 months
Intraductal ____ Neoplasms bear KRAS and GNAS mutations. A) Oncocytic Papillary B) Tubulopapillary C) Papillary Mucinous #GIPath #PathTwitter #PathResidents
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@DrCycloPath
Charles Herndon
4 months
A or B = follicular lymphoma? #HemePath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
6 months
60F stomach, submucosal lesion, diagnosis? A) Gastrointestinal stromal tumor B) Plexiform fibromyxoma C) Inflammatory myofibroblastic tumor D) Inflammatory fibroid polyp #GIPath #BSTPath #Pathology #PathTwitter #PathX
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@DrCycloPath
Charles Herndon
1 month
Cystic lung tissue from a 12-month-old. Diagnosis? A) Lymphangioleiomyomatosis B) Pleuropulmonary blastoma C) Pulmonary blastoma #pulmpath #pathresidents #pathresidents #pedipath
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@DrCycloPath
Charles Herndon
6 months
A or B = Eosinophilic Vacuolated Tumor? #GUPath #PathResidents #PathTwitter 🖼️🙏Dr. Victor Reuter
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@DrCycloPath
Charles Herndon
11 months
Diagnosis? A) Ductal Carcinoma In Situ B) Usual Ductal Hyperplasia 🔬H&E 🔬CK5/6 🔬ER 📝notebook #breastpath #breastcancer #pathology #pathresidents #pathologists #pathtwitter #pathx
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@DrCycloPath
Charles Herndon
1 year
Appendix. Goblet Cell Adenocarcinoma or Goblet Cell Carcinoid? #gipath #pathresidents #pathtwitter #pathx #PathMatch2024 #pathology #pathologists 📝
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@DrCycloPath
Charles Herndon
8 months
A or B = low-grade fibromyxoid sarcoma A) thigh of 50yo B) thigh of 20yo #BSTPath #PathTwitter #PathResidents #DermPath
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@DrCycloPath
Charles Herndon
11 months
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@DrCycloPath
Charles Herndon
4 months
Which cell is characteristically seen in nodular sclerosis CHL? a) Hodgkin Cell b) Mummified Cell c) Reed-Sternberg Cell d) Lacunar Cell #HemePath #PathTwitter #PathResidents #Pathology CHL: Classic Hodgkin Lymphoma
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@DrCycloPath
Charles Herndon
8 months
Which bone lesion is benign? A or B? #BSTPath #PediPath #PathResidents #PathTitter
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@DrCycloPath
Charles Herndon
2 months
5 year-old with arrhythmia due to cardiac ____ A) myxoma B) rhabdomyoma C) papillary fibroellastoma D) fibroma #PediPath #BSTPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
10 months
Salivary gland, ___ carcinoma. A) adenoid cystic B) acinic cell C) salivary duct D) mucoepidermoid #CytoPath #DermPath #PathResidents #PathTwitter #ENTPath #BSTPath 🔬 # 8 & 9
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@DrCycloPath
Charles Herndon
2 months
Endometrial stromal ___ a) nodule b) sarcoma 🔬 @Pathologists #GYNPath #PathTwitter #Pathology #BSTPath
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@DrCycloPath
Charles Herndon
9 days
Smoker's macrophages = A or B? #PulmPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
8 months
🐞 & scattered giant cells, diagnosis? A) Tenosynovial Giant Cell Tumor B) Pigmented Villonodular Synovitis C) Giant Cell Tumor of Tendon Sheath D) Any one of these #BSTPath #PathResidents #PathTwitter 📽️🙏 @JMGardnerMD
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@DrCycloPath
Charles Herndon
10 months
50F, kidney, diagnosis? A) Metanephric Adenoma B) Papillary RCC C) Wilm's Tumor (epithelial predominant) #GUPath #PathResidents #PathTwitter 🔬
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@DrCycloPath
Charles Herndon
2 months
27M abdominal mass, diagnosis? A) Ewing sarcoma B) Desmoplastic small round cell tumor C) Alveolar rhabdomyosarcoma #Pathology #PathTwitter #BSTPath #PediPath
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@DrCycloPath
Charles Herndon
9 months
10yo boy with a GIST & lymph node metastasis. Which gene is most likely mutated? A) KIT B) SDH C) PDGFRA D) None of the above #PediPath #GIPath #BSTPath #PathTwitter #pathresidents
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@DrCycloPath
Charles Herndon
1 month
20M intracranial mass, diagnosis? A) hemangioblastoma B) hemangiopericytoma (i.e., SFT) C) meningioma, microcystic variant #Neuropath #PediPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
8 months
Ovarian ___ Tumor A) Adult Granulosa Cell B) Yolk Sac C) Sertoli Leydig Cell D) Microcystic Stromal #GYNPath #PathTwitter #GUPath #PathResidents
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@DrCycloPath
Charles Herndon
4 months
Hallmark cells with ___ positivity are essential diagnostic features of ALCL a) ALK b) CD30 c) CD3 d) CD4 #HemePath #PediPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
7 months
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@DrCycloPath
Charles Herndon
6 months
Thyroid, diagnosis? A) Hashimoto Thyroiditis, Fibrosing Variant B) Reidel Thyroiditis C) Diffuse Sclerosing Variant of PTC #ENTPath #EndoPath #PathResidents #PathTwitter #Thyroid #BSTPath 🔬
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@DrCycloPath
Charles Herndon
9 months
CNS Histiocytosis A) Langerhans Cell Histiocytosis B) Rosai Dorfman Disease #NeuroPath #PediPath #BSTPath #PathTwitter #PathResidents #Pathology ✏️notebook 😊my first 📽️
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@DrCycloPath
Charles Herndon
4 months
Toxoplasma lymphadenitis classically demonstrates a) monocytoid B cell hyperplasia b) reactive follicular hyperplasia c) epithelioid histiocytosis d) all of the above #HemePath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
3 months
Retroperitoneal lymph node involved by _____ a) sertoli cell tumor b) leydig cell tumor c) DLBCL d) seminoma #GUPath #PathTwitter #Pathology #HemePath
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@DrCycloPath
Charles Herndon
16 days
Thyroid mass, 1st impression? A) Synovial sarcoma B) Intrathyroid thymoma C) Spindle epithelial tumor with thymus-like elements 🔬 #BSTPath #EndoPath #PathTwitter #pathology
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@DrCycloPath
Charles Herndon
3 months
Gastritis with infiltrating plasma cells filled with ___ bodies a) Russell b) Dutcher #GIPath #HemePath #PathTwitter 🔬
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@DrCycloPath
Charles Herndon
9 months
HPV-associated or HPV-independent cervical cancer? #GYNPath #PathTwitter #PathResidents
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@DrCycloPath
Charles Herndon
5 months
Brown mucosa on endoscopy due to macrophages full of _____ A) iron B) lipofuscin C) drug crystals #GIPath #Pathology #PathTwitter #PathX 🖼️🙏 @WebPathology
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@DrCycloPath
Charles Herndon
4 months
Ig__ expressing LP cells in NLPHL are associated with ___ #HemePath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
6 months
Deficiency in ___ repair can be associated with the __ pattern of ovarian high grade serous carcinoma. A) mismatch B) homologous recombination #gynpath #pathresidents #PathTwitter #pathology
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@DrCycloPath
Charles Herndon
11 months
Lung mass. A) Paraganglioma B) Neuroendocrine tumor C) Pseudoendocrine sarcoma 🔬 #bstpath #pathology #pathologists #pathresidents #pulmpath #pathtwitter #pathx #neuropath
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@DrCycloPath
Charles Herndon
4 months
Clear Cell Sarcoma-like Tumor of the GI Tract ___ a) shows EWSR1 rearrangement b) has melanocytic differentiation c) usually affects older adults d) is most common in the stomach #GIPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
9 months
Bladder. Diagnosis? A) Normal B) Carcinoma #GUPath #PathTwitter #PathResidents
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@DrCycloPath
Charles Herndon
4 months
Pulmonary lymphangioleiomyomatosis usually _______ #PulmPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
6 months
Pigmented lesion. Diagnosis? A) Lentiginous nevus B) Congenital pattern nevus C) Solar lentigo D) Melanoma in situ #dermpath #bstpath #pathtwitter #pathresidents #dermatology #dermpath 🖼️🙏 @JMGardnerMD
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@DrCycloPath
Charles Herndon
5 months
____ is a rare tumor of the stomach antrum that arises in the ___ layer A) Plexiform fibromyxoma B) Inflammatory fibroid polyp C) Glomus tumor #GIPath #PathTwitter #pathology #BSTPath
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@DrCycloPath
Charles Herndon
6 months
___ sialadenitis of the parotid gland A) IgG4 B) Lymphoepithelial C) NOS Chronic #ENTPath #PathResidents #PathTwitter 🖼️🙏 @WebPathology
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@DrCycloPath
Charles Herndon
1 year
3 nephrectomies, 1 renal cell carcinoma (RCC). Diagnosis? Who, patient A, B, or C, has a poor prognosis? Need IHC or molecular? (opinion, see comment) Notes: Edits appreciated. #PathTwitter #GUPath #PathMatch2024 #PathResidents
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@DrCycloPath
Charles Herndon
8 months
Kidney tumor with what 🧬 alteration? A) DICER1 mutation B) SS18::SSX fusion C) ETV6::NTRK3 fusion D) None of the above #GUPath #PathTwitter #PathResidents #PediPath #BSTPath #MolPath
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@DrCycloPath
Charles Herndon
3 months
70yo man with malabsorption & polyps. What syndrome does he have? a) Peutz-Jeghers Syndrome b) Cronkhite-Canada Syndrome c) Juvenile Polyposis Syndrome d) FAP Syndrome #GIPath #PathTwitter #PediPath #Pathology
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@DrCycloPath
Charles Herndon
5 months
Adenomas of the ___-type show expression of ___ mucin(s) a) intestinal b) foveolar c) pyloric d) oxyntic #GIPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
2 months
Necrotic areas in ___ lymphadenopathy contain hematoxylin bodies a) systemic lupus b) Kikuchi-Fujimoto #HemePath #BSTPath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
6 months
Serrated sigmoid polyp. Diagnosis? A) Sessile serrated lesion B) Perineurioma C) Schwann cell hamartoma D) Schwannoma #GIPath #BSTPath #PathTwitter #pathology
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@DrCycloPath
Charles Herndon
3 months
In progressive transformation of germinal centers, infiltrating mantle cells express a) SOX11 b) cyclin D1 c) CD20 d) BCL6 #HemePath #PathTwitter #Pathology
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@DrCycloPath
Charles Herndon
10 months
Stomach biopsy with a humbling finding. Do you see why? Be honest. #PathResidents #GIPath #PathTwitter 🔬
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@DrCycloPath
Charles Herndon
9 months
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@DrCycloPath
Charles Herndon
10 months
17M, femoral epiphysis, diagnosis? A) Giant Cell Tumor of Bone B) Epithelioid Hemangioendothelioma C) Chondroblastoma D) Eosinophilic Granuloma 🔬 #PathResidents #PathTwitter #BSTPath #PediPath
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@DrCycloPath
Charles Herndon
10 months
Where are we? A) Parotid gland B) Pancreas C) Sublingual gland #PathTwitter #GIPath #ENTPath #DermPath #BSTPath #PathResidents
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@DrCycloPath
Charles Herndon
9 months
Reindeer🦌 vessels in a 1yo boy🧑‍🎄 Molecular finding? A) NAB2::STAT6 B) SS18 rearrangement C) ETV6::NTRK3 🔬 #PediPath #BSTPath #PathTwitter #PathResidents #Pathology
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@DrCycloPath
Charles Herndon
1 month
The jaw is the most common bone involved by___. A) Mesenchymal chondrosarcoma B) Desmoplastic small round cell tumor C) Synovial sarcoma D) CIC-rearranged sarcoma #BSTPath #PathTwitter #pathology 🔬
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@DrCycloPath
Charles Herndon
6 months
Multiple ___ is a major diagnostic criterion for ___ Syndrome A) Cylindromas B) Trichilemmomas C) Sebaceous adenomas D) Basal cell carcinomas #pathtwitter #bstpath #dermpath #pedipath
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@DrCycloPath
Charles Herndon
7 months
lipoblast atypia consistent with pleomorphic liposarcoma stromal spindle cell atypia consistent with atypical lipomatous tumor/ well-diff liposarcoma lipoblastoma lacks stromal & lipoblast atypia pleomorphic lipoma has multinucleate tumor-like giant cells #BSTPath #PathTwitter
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@DrCycloPath
Charles Herndon
7 months
Lung mass. Is it cancer? #PulmPath #PathResidents #PathTwitter 🙏 @6Patterns 🎥 🔬
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@DrCycloPath
Charles Herndon
9 months
____ is essential to diagnose keratinizing SCC of the lung. A) At a minimum, +p40 IHC B) +p40 with -TTF1 IHC C) No IHC #PulmPath #PathTwitter #Pathology #PathResidents 🔬
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@DrCycloPath
Charles Herndon
9 months
What is the most common ALK immunoreactivity pattern for inflammatory myofibroblastic tumor? A)🔬 B)🔬 C)🔬 D) All or none #BSTPath #GIPath #BreastPath #DermPath #MolPath #Pathology #PathResidents #PathTwitter
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@DrCycloPath
Charles Herndon
1 month
___ most commonly arises on the big toe A) Fibroma of tendon sheath B) Superficial acral fibromyxoma C) Inclusion body fibromatosis #PathTwitter #BSTPath #DermPath #Pathology
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