David Mayhew @DavidLMayhew Twitter profile

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David Mayhew

@DavidLMayhew

1 year

As of today the entire Brigham & Women’s system in Boston is not accepting any new patients for primary care. This is US healthcare. @BrighamWomens

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David Mayhew

@DavidLMayhew

2 years

@unusual_whales “Secret”

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David Mayhew

@DavidLMayhew

3 years

I just got done reviewing a paper for which I was reviewer 5. Five. Is this necessary?

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David Mayhew

@DavidLMayhew

1 year

@pathforward327 @jwarrenreincarn @BrighamWomens The US has less government in healthcare than any other developed nation. We also have the most problems in healthcare, spend the most, and get the least for our money. It’s almost like when all parties are trying to maximally extract $ from the patient, that has an impact.

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David Mayhew

@DavidLMayhew

2 years

@caitlinmoriah Absolutely. This attitude of “*I* alone did it, *I* am amazing, and *I* can make you amazing too” is absolutely baffling to me. Highlighting their own “greatness” and not the people who helped lift them up along the way is an immediate turn off for me.

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David Mayhew

@DavidLMayhew

9 months

Data on cancer incidence and death rates through 2021. COVID vaccines had EUA in 12/2020. No uptick in cancer incidence or death. No “turbo cancer” (a made up term that doesn’t exist). Antivaxxers get it wrong yet again.

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David Mayhew

@DavidLMayhew

1 year

@KrugAlli Apparently everyone is taking about drinking water. This is a complex question, and I have a couple thoughts this morning. 1/193

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David Mayhew

@DavidLMayhew

2 years

@jakeshieldsajj No, a bivalent vaccine is replacing the monovalent vaccine. That means it covers 2 strains now instead of just 1. The “half amount” is just the standard booster dose for Moderna. Pfizer’s dose is unchanged.

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David Mayhew

@DavidLMayhew

5 years

@mcsassymd your tweet made it into a legit medical journal. You have arrived. 🙌

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David Mayhew

@DavidLMayhew

3 years

@BuckDancerMD I wish people understood the full implications of the antivaxx disinformation they spread.

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David Mayhew

@DavidLMayhew

2 years

@BrynnTannehill It also appears that a transgender person simply signing along with a song they like at a bar could qualify under this law. This despicable law is meant to suppress transgender existence, not “performance.”

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David Mayhew

@DavidLMayhew

7 years

@neiltyson A lot of offended people here. He only stated that scientists retain curiosity, NOT that certain other professions do not.

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David Mayhew

@DavidLMayhew

1 year

What is this nonsense?

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David Mayhew

@DavidLMayhew

2 years

@ShanePaulNeil Also this.

Tristan Snell

@TristanSnell

2 years

UPDATE: the Uvalde killer was engaged by law enforcement outside the school *BEFORE* he went inside. More cops at schools: not the answer. Arming teachers: not the answer.

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David Mayhew

@DavidLMayhew

1 year

@HouseBoatDoc @BrighamWomens It’s more about keeping the lights on and the bills paid with a reimbursement structure that doesn’t value primary care.

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan Your primers bound in multiple locations in the SV40 promoter, the smallest product being ~20% of the whole promoter, making your qPCR data uninterpretable. If you can't even get primer design right, what chance do you have for the rest of it? What a joke.

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David Mayhew

@DavidLMayhew

3 years

I believe the term “leadership” is often misused in academia. Too many believe it’s about accumulating personal accolades, resulting in people competing & jockeying for position while focusing only on themselves. Far too few see it as an opportunity to focus on & serve others.

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David Mayhew

@DavidLMayhew

1 year

@SenRonJohnson @US_FDA The FDA has not approved ivermectin for use in COVID, quietly or otherwise.

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David Mayhew

@DavidLMayhew

1 year

@MarkELindsay @BrighamWomens Absolutely agree. This is the market responding to incentives.

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David Mayhew

@DavidLMayhew

1 year

This thread is a classic acting out after a narcissistic injury. Seriously, Kevin. Seek help.

How to Spot a Narcissist Online

Studies have shown narcissists post more self-promoting content on social media, but it's not always so easy to tell if someone's doing it for the attention.

www.theatlantic.com

Kevin McKernan

@Kevin_McKernan

1 year

You might want to wear black for this debunkers obituary. All of these folks came out strong arguing these points. As they have been proven wrong, they never correct their tweets. Just move goal posts and keep harassing people. No humility in light being fried.

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David Mayhew

@DavidLMayhew

1 year

@0xKefka @BrighamWomens @ExBridgewater I’ve never meet a single primary care physician who went into biopharma. It’s all specialists.

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David Mayhew

@DavidLMayhew

1 year

@TracyBethHoeg @StabellBenn @joshg99 @RetsefL @Kevin_McKernan Kevin is so bad at science that he designed primers that bind multiple locations within the SV40 promoter, making his qPCR data uninterpretable. His other quantification method (Qubit) was hopelessly inflated by the RNA in the sample. Most of his data are likely artifact.

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David Mayhew

@DavidLMayhew

1 year

@pathforward327 @jwarrenreincarn @BrighamWomens You repeating your opinion doesn’t change reality. When I was in med school, private health insurance overhead was 12%. Medicare overhear was 3%.

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David Mayhew

@DavidLMayhew

2 years

@mfcannon Can you provide details on this “innovation” in insulin you speak of? I’m sure all us physicians and scientists would love to learn about this magic from someone primarily motivated by political grievances.

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David Mayhew

@DavidLMayhew

3 years

@saltylungs “If you had infinite resources, what would be your first initiative to improve the workplace?” Frames it in terms of a positive (fixing issues), not a negative (airing grievances). IMO you’re more likely to get an honest answer when framed this way.

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David Mayhew

@DavidLMayhew

2 years

@naomirwolf This has always been asked of anyone who gets evaluated for a fall due to increased chance of bleeding. This is standard of care. It’s really not that difficult to comprehend and isn’t a conspiracy.

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David Mayhew

@DavidLMayhew

2 years

@mfcannon Thanks for the generic buzzwords. How *specifically* has production, distribution, delivery, formulation, or shelf life changed on the generic insulin formulation that hasn’t changed in 40 years? Don’t forget to be specific.

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David Mayhew

@DavidLMayhew

4 years

@danbrownIO Radiation Oncology

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David Mayhew

@DavidLMayhew

10 months

@MdBreathe @molsjames @US_FDA @CDCDirector Step 3… pay you money?

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David Mayhew

@DavidLMayhew

4 years

I had an MRI recently. The hospital charged over $12,000 for it. Twelve. Thousand. Dollars. Healthcare inflation is unsustainable and, ultimately, completely unethical.

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David Mayhew

@DavidLMayhew

4 years

I had a joke about the ABR oral exam, but then I didn’t want to tell it. Then I did. Then I didn’t. Then I did.

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David Mayhew

@DavidLMayhew

1 year

@josephazam @Airbnb I’m very sorry this happened. A host tried to manipulate/extort multiple $1000s from us also. We kept getting passed from @AirbnbHelp customer service rep to rep. None were willing to resolve the case & few even read the file. Escalatation resolved it after WEEKS.

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David Mayhew

@DavidLMayhew

2 years

@bariweiss Where have I heard that before?

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan You’re claiming that primer was functional in your PCR? Did you run your PCR with an annealing temp of 37°C? Because that’s the Tm of the overlap. For all of Kevin’s followers that don’t know better: that’s about 20°C lower than most PCRs. That’s never done. His PCR was 💩.

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David Mayhew

@DavidLMayhew

1 year

@NChartierET @Kevin_McKernan ’s data is completely useless. DNA is perhaps one of the easiest things to measure in all of biology, and he screwed it up royally. He couldn’t even design his primers correctly.

David Mayhew

@DavidLMayhew

1 year

@TracyBethHoeg @StabellBenn @joshg99 @RetsefL @Kevin_McKernan Kevin is so bad at science that he designed primers that bind multiple locations within the SV40 promoter, making his qPCR data uninterpretable. His other quantification method (Qubit) was hopelessly inflated by the RNA in the sample. Most of his data are likely artifact.

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David Mayhew

@DavidLMayhew

6 years

@AllisonRBond When I was a resident and had a female attending, patients would sometimes turn to me after she spoke and ask for me to validate what she said. I would say “Dr. X, who to be clear is my boss, has outlined a great plan for you. Do you have any other questions for her?”

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David Mayhew

@DavidLMayhew

8 months

@NGrossman81 By SCOTUS’s interpretation, couldn’t a supermajority of 1 party simply bar potential candidates of the other party from running for the Presidency? How does placing responsibility in the hands of nakedly political actors make this a more fair process?

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David Mayhew

@DavidLMayhew

2 years

@RisetteMD But it’s how anti-vaxxers *think* neurologic conditions look. So there’s that.

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David Mayhew

@DavidLMayhew

1 year

@KrugAlli @BallouxFrancois @apsmunro Making things up is not a legitimate form of science or medicine. Can you show any data at all to support these concerns?

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David Mayhew

@DavidLMayhew

2 years

Who else grew up with these bowls in their household?

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David Mayhew

@DavidLMayhew

1 year

@Mossflowr It’s a fountain of something all right.

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David Mayhew

@DavidLMayhew

3 years

@AlghalayiniLulu @kjdelay1 Those Z names never stood a chance.

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan @TracyBethHoeg @StabellBenn @joshg99 @RetsefL Qubit was used to measure RNA by Pfizer, not DNA like you did. Your readings were contaminated by the massive amounts of RNA in the sample, as many others have pointed out to you. See, it’s this kind of sloppy work that leads to the research products you produce.

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David Mayhew

@DavidLMayhew

1 year

@Cartophiliast @BrighamWomens Primary care docs, not all docs, are the relevant population here. PCPs make FAR less $ and are in very short supply.

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David Mayhew

@DavidLMayhew

2 years

@violetkathyw @jakeshieldsajj Extensive safety trials have been done in humans. This appears to be the paper you’re referencing? There are nearly 200 groups compared in this paper, each of which have 8-10 mice per group. They did just fine. No problems.

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5...

Nature Medicine - Bivalent vaccines elicit broad immune responses that neutralize ancestral SARS-CoV-2 and variants of concern and offer a customizable approach to protect from COVID-19 as new...

www.nature.com

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David Mayhew

@DavidLMayhew

3 years

@DrRupaMarya It’s pretty easy to see why once you realize who the customers are who purchase the EMRs. It’s not the MDs who use the software. It’s the administrators, who are more interested in capturing every billable dollar. They couldn’t care less if it makes our lives easier.

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David Mayhew

@DavidLMayhew

3 years

@DrJenGunter When the kit is used inappropriately, as he did, false positives can result. Using the correct buffer supplied with the kit is essential. Water is NOT an acceptable substitute. This paper debunks the disinformation this guy is spreading.

Generation of False-Positive SARS-CoV-2 Antigen Results with Testing Conditions outside Manufactu...

With the Panbio severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen test being deployed in over 120 countries worldwide, understanding conditions required for its ideal performance...

journals.asm.org

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David Mayhew

@DavidLMayhew

1 year

@genjibear @BrighamWomens At least we don’t have the long wait times like in Canada… oops

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David Mayhew

@DavidLMayhew

1 year

@TracyBethHoeg Asked and provided:

Association Between Universal Masking and SARS-CoV-2 Positivity Among Health Care Workers

This study describes SARS-CoV-2 PCR test positivity among health care workers before, during, and after implementation of a policy requiring universal masking of all health care workers and patients...

jamanetwork.com

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David Mayhew

@DavidLMayhew

3 years

@sir_osis @fuzzymittens Oh the irony.

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David Mayhew

@DavidLMayhew

2 years

@thomaschattwill 4 intelligence agencies say likely zoonotic, 2 are unsure, 2 claim possibly lab leak with differing degrees of certainty. The fact that you pick the 2/8 shows your bias, not science. More importantly, virologists who study this overwhelmingly think it was zoonotic.

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David Mayhew

@DavidLMayhew

1 year

@SolNataMD Insurers will have a “personal objection” to anything that costs a lot.

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David Mayhew

@DavidLMayhew

3 years

@DrRupaMarya All EMRs were originally created as billing software.

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David Mayhew

@DavidLMayhew

1 year

@BerryTartlet @Kevin_McKernan Yikes! Once I saw the disaster of the primers I didn’t even look at the probes!

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David Mayhew

@DavidLMayhew

1 year

@MakisMD @crabb_vicki That’s a lot of words to say “I have no idea what I’m talking about.”

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David Mayhew

@DavidLMayhew

3 years

@TakeWeightOffMD @EricTopol @NEJM No prospective trial is powered for that. Hence the need for phase IV trials.

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David Mayhew

@DavidLMayhew

1 year

@slavov_n @ScienceAdvances “We don’t like research institutes outcompeting us by paying fair wages and providing better work environments.”

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David Mayhew

@DavidLMayhew

2 years

@KenFigueroaLab @MicrobiomDigest On the upside, they now have incredible balance.

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David Mayhew

@DavidLMayhew

1 year

@weldeiry Kevin never showed any standardized quantified DNA amts until this preprint. He claimed vaxx was causing cancer, immune reactions, etc. However all DNA are *below regulatory limits.* He’ll spin it and never apologize for misleading people and claiming it was dangerous.

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David Mayhew

@DavidLMayhew

7 years

@McCormickProf I’ll never forget that the grandfather of my first ever patient in medical school was born a slave. That was in 2003. It’s that close.

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan Your own data isn’t reliable. R2 = 0.1 - 0.4 Qubit vs qPCR and you cherry pick the one that fits your narrative.

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David Mayhew

@DavidLMayhew

1 year

@ToTheMoon4257 @TommyLavinTST @notcapnamerica @GOP Maine has virtually no firearm restrictions. What else do you want? Mandatory carry by law?

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David Mayhew

@DavidLMayhew

6 years

@rwjohnsonPAs @babbymd @mcsassymd So they reach the brain BEFORE going into the bloodstream? 😂😂

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan “I don’t need to run any controls in my research because I start from the conclusion that I’m right and you just just trust me bro”

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David Mayhew

@DavidLMayhew

3 years

@charlesmurray @mbeisen @arbelharpak Your entire argument boils down to “I accounted for everything I could think of, so all remaining differences must be genetic.” Instead of recognizing that your models are incomplete & aren’t capturing all the environmentally relevant variables, you point to genes. Fair summary?

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David Mayhew

@DavidLMayhew

1 year

You’ve cultivated a following of uneducated anonymous flying monkeys. Prototypical narcissistic behavior.

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David Mayhew

@DavidLMayhew

1 year

@isobelks @BroyleTim @BrighamWomens More residency training positions, which is an important distinction.

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David Mayhew

@DavidLMayhew

2 years

@engineering_joy This K99/R00 timeline biases toward postdocs who walk into a project that was 1/2 completed, allowing them to have prelim data on day 1, and biases against those who start with an idea. Do we want more systems that benefit large/rich labs that have more data sitting around?

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David Mayhew

@DavidLMayhew

2 years

@ajbauer No one has the ability to boycott SCOTUS, but people do have the ability to boycott places that institute draconian laws.

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan Not to mention you pick the one that’s more likely to be contaminated by the massive amounts of RNA in the samples. You refused to use RNase in the analysis bc someone else didn’t use it? That makes no sense.

Kevin McKernan

@Kevin_McKernan

1 year

@midorinoaojiru Because there is no evidence that Pfizer treated their samples with nucleases before using fluorometry.

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David Mayhew

@DavidLMayhew

4 years

Update: the cells lived, but I told them about 2020 and they all apoptosed immediately and honestly I can’t blame them.

David Mayhew

@DavidLMayhew

4 years

I just thawed some cells from 1998.

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David Mayhew

@DavidLMayhew

3 years

@pdhsu Biology theory:

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David Mayhew

@DavidLMayhew

1 year

@ENirenberg This is incredibly embarrassing for @Kevin_McKernan . First year graduate student level task and he failed miserably.

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David Mayhew

@DavidLMayhew

1 year

@Jikkyleaks @Hammersmith84 @crabb_vicki @jennabgreen @dr_jon_l @Doctor_Eric_B @gorskon @CaulfieldTim @medicamentarii @MakisMD @DrCanuckMD @DrJacobsRad @19joho @DrEricDing 1. It was a natural viral contaminant found and ELIMINATED from some lots of polio vaccine in 1963. That’s 60 years ago. Molecular biology has progressed light years since then. 2. mRNA vaccines for SARS-CoV-2 do not and cannot cause cancer.

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David Mayhew

@DavidLMayhew

1 year

@jasonrantz @HokiePharmacist Prescriptions, how do they work?

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David Mayhew

@DavidLMayhew

6 years

@PGHobgyn @Skysong2015 @Cernovich 100%

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David Mayhew

@DavidLMayhew

4 years

Autumn in New England is magic.

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David Mayhew

@DavidLMayhew

1 year

@Jikkyleaks @Hammersmith84 @crabb_vicki @jennabgreen @dr_jon_l @Doctor_Eric_B @gorskon @CaulfieldTim @medicamentarii @MakisMD @DrCanuckMD @DrJacobsRad @19joho @DrEricDing There is no promoter in the SARS-CoV-2 vaccines. Promoters are in DNA to induce transcription, the vaccine is made of RNA only. Even if true, a promoter is not a whole virus. Come on, this is very basic stuff…

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David Mayhew

@DavidLMayhew

3 years

@NGrossman81 It’s parsing of the word “sanitation” in the law that is completely ignorant of it’s intention, or of infectious disease or science generally. She stated “Wearing a mask cleans nothing.” Wrong. Masks clean the air.

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David Mayhew

@DavidLMayhew

3 years

@CharlesMBrenner Not a cult at all… 🙄

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David Mayhew

@DavidLMayhew

10 months

@molsjames Hey Mollie, I’ve only talked about COVID vaccines, which is a sector I don’t work in and by companies I don’t work at. Or do you think I would “shill” for direct competitors? Didn’t really think this one through, did you?

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan T7 is directly relevant to the in vitro transcription reaction, which is used to make the RNA. EMA regulators state the whole plasmid sequence was submitted and the SV40 promoter element is not relevant to the final product. Your biased opinion is not relevant.

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David Mayhew

@DavidLMayhew

1 year

@TracyBethHoeg As much as you may want to, you don’t get to selectively edit data to fit your narrative. The colors are when specific actions were taken. No mystery there.

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David Mayhew

@DavidLMayhew

5 years

Thank you @ConquerCancerFd and @ASCO for supporting my work on YAP1 in colorectal cancer, and thank you @loxooncology for supporting the award! It’s support like yours of early physician-scientists that will help push oncology forward! @DanaFarber @DanaFarberNews

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David Mayhew

@DavidLMayhew

3 years

@WFKARS Thoughts an prayers may help your mitochondria. And a GoFundMe page, of course.

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David Mayhew

@DavidLMayhew

1 year

@PickledKenny @BrighamWomens I worry about being able to deliver anything resembling healthcare at that price.

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David Mayhew

@DavidLMayhew

2 years

@RepMTG @P_McCulloughMD @Rasmussen_Poll This is a lie. Stop spreading disinformation. Stop it.

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David Mayhew

@DavidLMayhew

11 months

@sethbannon @ATrotmanGrant Newsflash: tech bro spectacularly underestimates the complexity and uncertainty of biology.

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David Mayhew

@DavidLMayhew

10 months

@MdBreathe @molsjames @US_FDA @CDCDirector Learn how Twitter works, Mary. The comment was directed at Mollie. You’ve gone totally off the deep end. Good luck in your hearing in April, 2024 in front of the Texas Medical Board. You’re going to need it.

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David Mayhew

@DavidLMayhew

2 years

@LornaBracewell @ajbauer Respectfully disagree. One doesn’t need permission to take action on gross violations of human rights.

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David Mayhew

@DavidLMayhew

1 year

@TheRealJoeSnow1 @SenRonJohnson @US_FDA It was approved for other indications and can be used off-label. That does not make it approved or effective for other indications, even if it technically can be prescribed.

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David Mayhew

@DavidLMayhew

1 year

@NUMTyDumpty @Navaraaa @Kevin_McKernan Not how it works. They used poor methods and dumpster diving into a notoriously inaccurate database (VAERS). It’s not an “impactful paper.” It’s trash. Garbage in, garbage out.

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David Mayhew

@DavidLMayhew

1 year

@Hammersmith84 @crabb_vicki @jennabgreen @dr_jon_l @Jikkyleaks @Doctor_Eric_B @gorskon @CaulfieldTim @medicamentarii @MakisMD @DrCanuckMD @DrJacobsRad @19joho @DrEricDing In medicine we use specific terminology for specific reasons and at specific times. “…outside the expected parameters for its type” is completely insufficient as a diagnostic criterion. Vaccination does not cause more aggressive cancers.

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David Mayhew

@DavidLMayhew

3 years

@KimberlyBlumen1 @AnupamBJena Work life graft vs host, because it’s foreign, painful, leaves you immunocompromised, and ultimately will be the cause of your death.

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David Mayhew

@DavidLMayhew

1 year

@Kevin_McKernan What’s your next argument? That the kanamycin resistance gene is toxic?

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David Mayhew

@DavidLMayhew

1 year

@Navaraaa @Kevin_McKernan Desk rejection within 30 minutes.

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David Mayhew

@DavidLMayhew

3 years

@sunjay_shah @SbrtSean I’m a Rad Onc and I spend 90% of my time on molecular oncology. The kind of attitude that forfeits over basic research on mechanisms of oncogenesis, tumor microenvironment, IO, etc to other specialities will land Rad Onc in trouble. Choose to lead our specialty into the future.

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David Mayhew

@DavidLMayhew

2 years

Hot take: future theoretical radiation sensitizing drugs will be more successful when combined with radiopharmaceuticals than with external beam.

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David Mayhew

@DavidLMayhew

1 year

@GChristiemd @Mickolas9 @parden04 @GuyLambertUK If you think that demonstrating to your LGBT patients that you provide a safe place to seek care is “political,” then you have no business practicing medicine. Don’t you think they could be, as you say, “hurting, terrified, and anxious” because of attitudes like yours?

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David Mayhew

@DavidLMayhew

5 years

@LactatedRingers Physicians fill many rolls in the healthcare system aside from individual patient care. Arguably the most dire need in mental healthcare is at the systemic and policy level. He will be well poised to address that. Bravo @MikeMcClurkinMD for bring forward-thinking!

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