Connor Payne @Chemist_Payne Twitter profile

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Connor Payne

5 months

Check out these amazing stories led by a fantastic group of collaborators in the labs of @brian_b_liau , @LabZheng , Philip Cole, @drpaulnorthcott , @mazit . This was such a fun project to work on and I’m glad our lab could help contribute! #molecularglues #quaternarycomplex

Brian Liau

@brian_b_liau

5 months

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1 : #2 :

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Connor Payne

@Chemist_Payne

3 years

I can’t be the only chemist who has a weird attachment to those 1 or 2 spatulas that you maintain in perfect condition and which you trust with your life to weigh out those precious compounds #AcademicTwitter #RealTimeChem

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Connor Payne

@Chemist_Payne

3 years

On @biorxivpreprint we report a direct TR-FRET-based protein quantification strategy (<1 h from lysis➡️read) in unmodified cell lines. If you're into PROTACs, and you hate running Westerns, check it out! Mini-thread: (1/n)

A direct high-throughput protein quantification strategy facilitates discovery and characterization...

We describe a generalizable time-resolved Förster resonance energy transfer (TR-FRET)-based platform to profile the cellular action of heterobifunctional degraders (or proteolysis-targeting chimeras;...

www.biorxiv.org

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Connor Payne

@Chemist_Payne

8 months

Our newest work in collaboration with Saki Ichikawa and @drcmwoo @mazit is now online @CellChemBiol ! Here is a free-to-read link:

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Connor Payne

@Chemist_Payne

8 months

KYMERA THERAPEUTICS, INC - WO2024030628 - DEUTERATED STAT3 DEGRADERS AND USES THEREOF If that generic structure doesn't give you a seizure I am not sure what will

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Connor Payne

@Chemist_Payne

11 months

GENENTECH, INC - WO2023225302 - AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF (KRAS)

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Connor Payne

@Chemist_Payne

3 years

Today we report in @nchembio the development of CoraFluors, a versatile & accessible class of TR-FRET probes for chemogenomic applications (thread below).

Bright and stable luminescent probes for target engagement profiling in live cells

Nature Chemical Biology - CoraFluors, a class of macrocyclic terbium complexes for use in time-resolved FRET, exhibit physicochemical properties desirable for biological studies, including...

www.nature.com

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Connor Payne

@Chemist_Payne

8 months

ASTELLAS PHARMA INC - WO2024034591 - HETEROCYCLIC COMPOUND FOR INHIBITING AND/OR INDUCING DEGRADATION OF KRAS PROTEIN

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Connor Payne

@Chemist_Payne

2 years

Very happy to share the final version of our manuscript in @CellChemBiol . We developed a new assay strategy to both quantify target proteins & measure TE of small molecules - all using endogenous protein in lysates from unmodified cell lines. Oh, and it only takes 1 h ⌚️✅ (1/3)

Ralph Mazitschek

@mazit

2 years

Are you working in TPD/ #PROTAC -development and would welcome a simpler, faster, higher throughput way to quantify the abundance of endogenous target proteins directly in cell lysates, while getting a sensitive target engagement assay for ligand characterization for🆓?

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Connor Payne

@Chemist_Payne

3 years

Our paper is now online in its final form ( @CellChemBiol )! We show that the isoform and complex selectivity of HDAC inhibitors is governed by dynamic process in cellular contexts (1/2).

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Connor Payne

@Chemist_Payne

4 months

If you liked the versatile TR-FRET methodology we reported in our cyclimid paper, check out our detailed @STARProtocols procedures. We are looking forward to seeing these approaches being (hopefully) broadly adapted! @mazit @drcmwoo & Saki Ichikawa

Connor Payne

@Chemist_Payne

8 months

Our newest work in collaboration with Saki Ichikawa and @drcmwoo @mazit is now online @CellChemBiol ! Here is a free-to-read link:

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Connor Payne

@Chemist_Payne

10 months

KYMERA THERAPEUTICS, INC - WO2023239645 - SMARCA DEGRADERS AND USES THEREOF

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Connor Payne

@Chemist_Payne

2 years

In our latest work @AnalysisSensing , we develop a highly versatile TR-FRET assay toolbox using #CoraFluor labeled nanobodies. Pick your favorite flavor and make TR-FRET easier than ever. @mazit (1/n)

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Connor Payne

@Chemist_Payne

7 months

ARVINAS OPERATIONS, INC - WO2024054591 - RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE Hey I know that inventor...

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Connor Payne

@Chemist_Payne

3 years

Me during my prolonged cell treatments, wondering if the data will fit the hypothesis

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Connor Payne

@Chemist_Payne

9 months

VIVIDION THERAPEUTICS, INC - WO2024010784 - PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS

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Connor Payne

@Chemist_Payne

9 months

PFIZER INC - WO2024009191 - PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS Pan-KRAS

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Connor Payne

@Chemist_Payne

2 years

Fantastic collaboration with @LabOppermann @UniofOxford , Anderson Lab @DanaFarber - ProRS as a novel therapeutic target in #MultipleMyeloma . Fun fact: our proline-uncompetitive ProRS inhibitor NCP26 was only the 6th molecule I made during my PhD!

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Connor Payne

@Chemist_Payne

2 years

@victornizet @microbe_megan Isn’t that tRNA (toad-RNA)?

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Connor Payne

@Chemist_Payne

8 months

ASTELLAS PHARMA INC - WO2024029613 - HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF MUTANT KRAS PROTEIN

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Connor Payne

@Chemist_Payne

2 years

Preprint out! KEAP1-CUL3 structure, an awesome new assay platform for BTB domain-containing proteins, and elucidating the mode of inhibition of CDDO...what a fantastic collaboration @mazit @MGHCSB @CmdOxford

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3...

KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 allowing NRF2 to accumulate...

www.biorxiv.org

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Connor Payne

@Chemist_Payne

7 months

ARVINAS OPERATIONS, INC - WO2024054876 - LEUCINE RICH REPEAT KINASE 2 (LRRK2) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE

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Connor Payne

@Chemist_Payne

7 months

CULLGEN (SHANGHAI) INC - WO2024056077 - MODIFIED PROTEINS AND PROTEIN BINDERS AND DEGRADERS "Provided herein are compounds, pharmaceutical compositions, and methods for binding or modulating a DDB1-and CUL4-associated factor 1 (DCAF1) protein"

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Connor Payne

@Chemist_Payne

11 months

FOGHORN THERAPEUTICS INC - WO2023220137 - PYRAZINE DERIVATIVES AND USES THEREOF BAF degraders

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Connor Payne

@Chemist_Payne

3 years

@AndrewIWong Does that make these bagel bites?

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Connor Payne

@Chemist_Payne

6 months

NOVARTIS AG, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - WO2024086361 - MOLECULAR GLUE DEGRADER COMPOUNDS AND USES THEREOF RING E3 ligase recruiters

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Connor Payne

@Chemist_Payne

3 years

It’s an honor for our work to be highlighted in what has become one of my monthly must-reads! Many thanks @CharlCrowe @alessiociulli lab for the review

Charlotte Crowe

@CharlCrowe

3 years

Our January 2022 Journal Club is out, and this month contains some very cool literature highlights by @SohiniBioPharma Aina and Kevin, a special feature on @drugitorg by @val_spiteri and an interview with TPD PhD student @hannahjanekc 🥳

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Connor Payne

@Chemist_Payne

9 months

ARVINAS OPERATIONS, INC - WO2024020522 - COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4

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Connor Payne

@Chemist_Payne

9 months

SCHRÖDINGER, INC - WO2024020534 - CYCLIC COMPOUNDS AND METHODS OF USING SAME MALT1 inhibitors

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Connor Payne

@Chemist_Payne

10 months

C4 THERAPEUTICS, INC - WO2023239750 - BICYCLIC-SUBSTITUTED GLUTARIMIDE CEREBLON BINDERS

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Connor Payne

@Chemist_Payne

10 months

KYMERA THERAPEUTICS, INC - WO2023250058 - STAT DEGRADERS AND USES THEREOF

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Connor Payne

@Chemist_Payne

6 months

KYMERA THERAPEUTICS, INC - WO2024092011 - IRAK DEGRADERS AND USES THEREOF Mediated by DCAF1-3?

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Connor Payne

@Chemist_Payne

8 months

KYMERA THERAPEUTICS, INC - WO2024039901 - CDK2 DEGRADERS AND USES THEREOF

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Connor Payne

@Chemist_Payne

10 months

TREELINE BIOSCIENCES, INC - WO2023244917 - 1,8-NAPHTHYRIDIN-2-ONE HETEROBIFUNCTIONAL BCL6 DEGRADERS

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Connor Payne

@Chemist_Payne

7 months

BRISTOL-MYERS SQUIBB COMPANY - WO2024059472 - MACROCYCLIC IMMUNOMODULATORS "macrocyclic compounds have been discovered that bind to PD-1 and are capable of inhibiting the interaction of PD-1 with PD-L1"

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Connor Payne

@Chemist_Payne

10 months

MIRATI THERAPEUTICS, INC - WO2023244604 - TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS

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Connor Payne

@Chemist_Payne

4 years

So grateful to have been a part of this amazing collaboration between scientists at @DanaFarber , @MGHCSB , @Harvard / @HarvardCCB / @harvardmed A rapid, scalable assay to detect #SARSCoV2 antibodies in patient plasma

Radek Nowak

@RPNowak

4 years

We have developed a scalable TR-FRET assay to detect #SARSCoV2 antibodies. 5 μL diluted serum + 10 μL detection mix. 1h incubation Read in a plate reader. That's it. @HongYue88665668 @Chemist_Payne , Alter lab, @mazit @eric_fischer @fischerlab1

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Connor Payne

@Chemist_Payne

7 months

VIVIDION THERAPEUTICS, INC - WO2024073587 - N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF

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Connor Payne

@Chemist_Payne

10 months

BRISTOL-MYERS SQUIBB COMPANY - WO2024006881 - WEE1 DEGRADING COMPOUNDS AND USES THEREOF

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Connor Payne

@Chemist_Payne

6 months

AMGEN INC - WO2024076672 - HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF

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Connor Payne

@Chemist_Payne

6 months

SCORPION THERAPEUTICS, INC - WO2024086809 - METHODS FOR TREATING CANCER Small molecules that restore p53 function

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Connor Payne

@Chemist_Payne

10 months

MONTE ROSA THERAPEUTICS, INC - WO2023244817 - SUBSTITUTED PIPERIDINES AS CK1A DEGRADERS

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Connor Payne

@Chemist_Payne

10 months

C4 THERAPEUTICS, INC - WO2023244764 - COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2

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Connor Payne

@Chemist_Payne

3 years

We got the cover! Check out our work on the development of CoraFluor TR-FRET probes 👇🏻👇🏻

Nature Chemical Biology

@nchembio

3 years

The cover of our November issue () features a class of luminescent terbium-based probes called CoraFluors () used for detecting ligand-bound protein targets by TR-FRET.

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Connor Payne

@Chemist_Payne

8 months

RECURSION PHARMACEUTICALS, INC - WO2024039689 - HETEROCYCLE RBM39 MODULATORS

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Connor Payne

@Chemist_Payne

7 months

ASTRAZENECA AB - WO2024062090 - PCSK9 INHIBITORS AND METHODS OF USE THEREOF

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Connor Payne

@Chemist_Payne

8 months

MERCK SHARP & DOHME LLC - WO2024044667 - SMALL MOLECULE INHIBITORS OF KRAS PROTEINS

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Connor Payne

@Chemist_Payne

6 months

KYMERA THERAPEUTICS, INC - WO2024092009 - PROTEIN DEGRADERS AND USES THEREOF More DCAF1-3

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Connor Payne

@Chemist_Payne

6 months

ARVINAS OPERATIONS, INC - WO2024086759 - MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE

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Connor Payne

@Chemist_Payne

2 years

This is a beautiful medicinal chemistry and assay development campaign led by @Mark_A_Tye @mazit . Very proud of this work! Check it out 👇🏻

Ralph Mazitschek

@mazit

2 years

In @NatureComms , we report the development of new inhibitor classes targeting the cytosolic prolyl-tRNA synthetase (PfcProRS) in Plasmodium, which we have previously identified as the molecular target 🎯of halofuginone.2/

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Connor Payne

@Chemist_Payne

9 months

ASTRAZENECA AB - WO2024013209 - PCSK9 INHIBITORS AND METHODS OF USE THEREOF

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Connor Payne

@Chemist_Payne

5 years

@gabeAppleton @Thundercat Well if you activate the nuclear flux capacitor and subsequently redirect power from the radiative energy coupler then yeah I would be obliged to agree

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Connor Payne

@Chemist_Payne

8 months

TAKEDA PHARMACEUTICAL COMPANY LIMITED - WO2024033845 - HETEROCYCLIC COMPOUND NLRP3 inflammasome inhibitors

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Connor Payne

@Chemist_Payne

1 year

Ok, ignoring the very much insane alchemy here (kudos to all authors!), am I the only one who's thinking...man, separating target molecule from starting material has to be an absolute pain!

Mark Levin

@LevinChem

1 year

Today we report a new strategy for C-to-N atom replacement in heterocycles. Led by @ChemieJisoo , with Colin Stein (visiting student from @GloriusGroup ) and in collaboration with @alecchristian14 at @Merck , we demonstrate a chemical "sticky end" approach.

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Connor Payne

@Chemist_Payne

2 years

Am I the only one who takes pride in guessing which journal a preprint article has been submitted to, solely by looking at the formatting of the manuscript? e.g., # of figures, capital vs lower case letters in fig. panels, use of “extended data” (easy Nature family identifier)

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Connor Payne

@Chemist_Payne

7 months

JNANA THERAPEUTICS, INC - WO2024059205 - TREATING PKU WITH SPIRO-SUBSTITUTED AND OTHER PIPERIDINE INHIBITORS OF SLC6A19 FUNCTION

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Connor Payne

@Chemist_Payne

6 months

MONTE ROSA THERAPEUTICS, INC - WO2024092039 - COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF CDK2 degraders mediated by CRBN

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Connor Payne

@Chemist_Payne

3 years

Beautiful work showing that supposedly “selective” HDAC inhibitors have deceived us once again

Christian Adam Olsen

@ChristianAOlsen

3 years

We have a new preprint out on kinetic evaluation of selected #HDAC inhibitors. The data by @CarlosMYruela suggest that the reportedly HDAC3-selective inhibitor, RGFP966, is virtually equipotent against HDACs 1–3, exhibiting slow-binding #kinetics .

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Connor Payne

@Chemist_Payne

3 years

Excited to share our latest preprint “Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors" on @CellCellPress Sneak Peek! Static enzymatic assays do not capture the full story of HDAC inhibitor selectivity... (1/n):

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Connor Payne

@Chemist_Payne

10 months

PRELUDE THERAPEUTICS INCORPORATED - WO2023245150 - KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY

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Connor Payne

@Chemist_Payne

11 months

PRELUDE THERAPEUTICS, INCORPORATED - WO2023220577 - 6,6A,7,8,9,10-HEXAHYDRO-5H-PYRAZINO[1',2':4,5]PYRAZINO[2,3-C]PYRIDAZINE DERIVATIVES AS SMARCA4 PROTEIN DEGRADERS FOR THE TREATMENT OF CANCER

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Connor Payne

@Chemist_Payne

2 years

Thank you @Dereklowe for the great commentary on our paper! 👇🏻

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Connor Payne

@Chemist_Payne

6 years

LCMS turbo pump gets replaced @ $12k quote....ELSD detector insantly shits the bed. I love this instrument #RealTimeChem

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Connor Payne

@Chemist_Payne

7 months

ELI LILLY AND COMPANY - WO2024054808 - PYRAZOLO[1,5-A]PYRIDINE AND IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS FGFR3 INHIBITORS FOR THE TREATMENT OF CANCER

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Connor Payne

@Chemist_Payne

8 months

MIRATI THERAPEUTICS, INC - WO2024044769 - SUBSTITUTED PYRIDOPYRIMIDINONES mutant PI3Ka inhibitors

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Connor Payne

@Chemist_Payne

7 months

PRELUDE THERAPEUTICS INCORPORATED - WO2024059806 - BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

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Connor Payne

@Chemist_Payne

10 months

MERCK SHARP & DOHME LLC - WO2023244554 - CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA

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Connor Payne

@Chemist_Payne

6 months

ASTELLAS PHARMA INC - KOTOBUKI PHARMACEUTICAL CO. LTD - WO2024090469 - FUSED PYRIDAZINE DERIVATIVE NLRP3 inflammasome inhibitor

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Connor Payne

@Chemist_Payne

7 months

TAKEDA PHARMACEUTICAL COMPANY LIMITED - WO2024064214 - SYNTHESIS OF CYCLOPROPANE CARBOXYLIC ACIDS

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Connor Payne

@Chemist_Payne

10 months

TREELINE BIOSCIENCES, INC - WO2023215482 - TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS

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Connor Payne

@Chemist_Payne

8 months

SEAGEN INC - WO2024030577 - IMMUNOSTIMULATORY ANTI-PD-L1-DRUG CONJUGATES

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Connor Payne

@Chemist_Payne

6 months

GENENTECH, INC - WO2024083168 - OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF KRAS inhibitors

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Connor Payne

@Chemist_Payne

9 months

CELGENE CORPORATION - WO2024026256 - SUBSTITUTED IMIDAZOPYRAZINE COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK3

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Connor Payne

@Chemist_Payne

10 months

RELAY THERAPEUTICS, INC - WO2024006776 - ESTROGEN RECEPTOR ALPHA DEGRADERS AND MEDICAL USE THEREOF

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Connor Payne

@Chemist_Payne

9 months

MERCK SHARP & DOHME LLC - WO2024020159 - MACROCYCLIC PEPTIDES TARGETING KRAS

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Connor Payne

@Chemist_Payne

11 months

PROMEGA CORPORATION - WO2023215432 - CIRCULARLY PERMUTED DEHALOGENASE VARIANTS Split-HaloTag system seems to be analagous to the HiBiT/LgBiT system

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Connor Payne

@Chemist_Payne

8 months

MATCHPOINT THERAPEUTICS INC - WO2024044731 - DIAZEPINO-THIENO-QUINOXALINE COMPOUNDS AND THEIR USE IN THERAPY MK2 inhibitors

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Connor Payne

@Chemist_Payne

7 months

ACCUTAR BIOTECHNOLOGY INC - WO2024073502 - HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS GID inhibitors

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Connor Payne

@Chemist_Payne

7 months

JAZZ PHARMACEUTICALS IRELAND LIMITED - WO2024047135 - SUBSTITUTED HETEROCYCLES AS RAS INHIBITORS

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Connor Payne

@Chemist_Payne

9 months

ARVINAS OPERATIONS, INC - WO2024020221 - MODULATORS OF TYK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE

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Connor Payne

@Chemist_Payne

2 years

@radscientist_ Is it just me or do the dewars and Airgas tanks only decide to psssSSSHHHHHH at the exact moment you walk close by, so as to scare the absolute s*** out of you

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Connor Payne

@Chemist_Payne

7 months

MERCK SHARP & DOHME LLC - WO2024064245 - PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3

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Connor Payne

@Chemist_Payne

10 months

AUTOBAHN THERAPEUTICS, INC - WO2024006985 - AMIDE PRODRUGS AND USES THEREOF FAAH prodrugs

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Connor Payne

@Chemist_Payne

10 months

DENALI THERAPEUTICS INC - WO2023240084 - COMPOUNDS, COMPOSITIONS, AND METHODS SARM1 inhibitors

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Connor Payne

@Chemist_Payne

10 months

BEIGENE, LTD - WO2023237049 - DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

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Connor Payne

@Chemist_Payne

9 months

ASTELLAS PHARMA INC - WO2024019103 - HETEROCYCLIC COMPOUND THAT ACTS ON G12D MUTANT KRAS PROTEIN

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Connor Payne

@Chemist_Payne

6 months

PFIZER INC - WO2024075051 - HSD17B13 INHIBITORS AND/OR DEGRADERS

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Connor Payne

@Chemist_Payne

7 months

REPARE THERAPEUTICS INC - WO2024069592 - N-(5-SUBSTITUTED-[(L,3,4-THIADIAZOLYL) OR (L,3-THIAZOLYL)](SUBSTITUTED)CARBOXAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING THE AMIDE COMPOUNDS AND OF THEIR USE Pol theta inhibitors

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Connor Payne

@Chemist_Payne

7 months

ORIC PHARMACEUTICALS, INC - WO2024059609 - PHARMACEUTICAL FORMS OF A CD73 INHIBITOR

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Connor Payne

@Chemist_Payne

9 months

BRISTOL-MYERS SQUIBB COMPANY - WO2024020084 - HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4

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Connor Payne

@Chemist_Payne

1 year

CELGENE CORPORATION/BRISTOL-MYERS SQUIBB COMPANY - WO2023212147 - HETEROCYCLIC COMPOUNDS AS MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS

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Connor Payne

@Chemist_Payne

11 months

KYMERA THERAPEUTICS, INC - WO2023220425 - BCL-XL/BCL-2 DEGRADERS AND USES THEREOF

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Connor Payne

@Chemist_Payne

10 months

MODULUS DISCOVERY, INC - ASTELLAS PHARMA INC - WO2023243601 - AZACYCLOALKYL CARBONYL CYCLIC AMINE COMPOUND Cathepsin C inhibitors

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Connor Payne

@Chemist_Payne

4 years

A great feature on @DoorDash @UberEats would be to have OPTIONAL (!) plastic silverware. I feel like 90+ percent of it that gets included with orders never gets used 👎🏻

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Connor Payne

@Chemist_Payne

4 years

Do you ever just realize that it’s 7 o’clock and the only sustenance you’ve given your body is that iced coffee you drank at 10 am? No? Just me?

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Connor Payne

@Chemist_Payne

9 months

F. HOFFMANN-LA ROCHE AG - WO2024017857 - NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES GPR17 antagonists

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Connor Payne

@Chemist_Payne

10 months

@MattDHannigan That tertiary amine getting a serious workout

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Connor Payne

@Chemist_Payne

8 months

SCORPION THERAPEUTICS, INC - WO2024030863 - PI3K-ALPHA INHIBITORS FOR THE TREATMENT OF CANCER

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Connor Payne

@Chemist_Payne

3 years

We look forward to how our approach will enable high-throughput screening efforts in the identification and characterization of new degraders! @mazit @TannousLab (7/n) #TRFRET #PROTAC #PROTACs #degrader #chemicalbiology #smallmolecules

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Connor Payne

@Chemist_Payne

3 years

Two birds with one stone: using clever biochemistry principles and a single POI-targeting antibody, we can rapidly & quantitatively measure both endogenous target engagement and protein levels in whole cell extracts, here exemplified for BRD4 (2/n)

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