Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major...

Nature Communications - Acute stress can help individuals to respond to challenging events, although chronic stress leads to maladaptive changes. Here, the authors present a multi omic analysis...

Nature Communications - Individuals vary considerably in how they are affected by stress. Here, the authors show that the severity of psychopathological symptoms triggered by prolonged real-life...

The attentional control of behavior is a higher-order cognitive function that operates through attention and response inhibition. The locus coerule...

Current Protocols is a comprehensive journal for protocols and overviews covering experimental design, scientific research methods and analyses across life sciences.

Caenorhabditis elegans worms produce and keep imprints of the attractive chemosensory cues to which they are exposed early in life. Imprinting enhances transiently or permanently chemoattraction to...

Translational Psychiatry - Title: “Labels Matter: Is it stress or is it Trauma?”

Nature Communications - Accurate phenotyping is key to deciphering behavior. Here, authors show the utility of the software package DeepOF in supervised and unsupervised identification of distinct...

Nature Neuroscience - Moliner et al. show that psychedelics directly bind to the BDNF receptor TrkB with high affinity and promote BDNF-mediated plasticity and antidepressant-like effects, whereas...

Circulating corticosterone levels show an ultradian rhythm resulting from the pulsatile release of glucocorticoid hormone by the adrenal cortex. Because th

Around 50% of patients with major depression do not respond to standard first-line treatments, such as psychotherapy and pharmacotherapy. At the same time, a subgroup exhibits altered functioning of...

The SCNAT provides funding for the establishment of a Global Stress and Resilience Network (GSRNet) with a coordination office under the guidance of behavioural neuroscientist Carmen Sandi at the...

Nature Metabolism - Ameroso et al. reveal a role for astrocytic brain-derived neurotrophic factor in the hypothalamus for regulating whole body energy homeostasis by means of TrkB.T1 receptor...

We normally regard sleep and wake as two distinct opposing brain states, where sleep requires silence of wake-promoting structures such as the locus coeruleus (LC)-norepinephrine (NE) system. We set...

Nature Reviews Neuroscience - Stress, a key risk factor for many neuropsychiatric disorders, drives a range of maladaptive physiological changes from genetic to behavioural levels. In this review,...

Response inhibition is a core executive function enabling adaptive behaviour in dynamic environments. Human and animal models indicate that inhibitory control and control networks are modulated by...

Models of cognitive function typically focus on the cerebral cortex, ignoring functional links to subcortical structures. This view neglects the highly-conserved ascending arousal system’s role and...