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Deniz Atasoy Profile
Deniz Atasoy

@AtasoyLab

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Assoc. Prof. @IowaNeuroPharm , interested in circuits for appetite & metabolism, circadian regulation, obesity & hypoglycemia. Atlas' & Zeus'(pitsky) dad.

Iowa City
Joined June 2019
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@AtasoyLab
Deniz Atasoy
1 year
The time of day that we eat has significant impact on body weight and metabolic health but what determines those mealtimes? In a new study @NatureNeuro , we monitored daily oscillations in the activity of key hypothalamic hunger neurons expressing AgRP. ++
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@AtasoyLab
Deniz Atasoy
10 months
Our trash panda made it to cover for the new issue of @NatureNeuro , highlighting our recent paper on the circuits encoding circadian feeding time. Artwork by @mikbalp
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@AtasoyLab
Deniz Atasoy
1 year
The time of day that we eat has significant impact on body weight and metabolic health but what determines those mealtimes? In a new study @NatureNeuro , we monitored daily oscillations in the activity of key hypothalamic hunger neurons expressing AgRP. ++
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@AtasoyLab
Deniz Atasoy
1 year
Brainstem is mainly associated with satiety while hunger signals are thought to act through hypothalamus. We describe NTS->PVN pathway activated by hunger signals & promotes feeding in part by adrenergic potentiation of GABA release onto PVN:MC4R neurons.+
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@AtasoyLab
Deniz Atasoy
2 years
Pleased to share our work on serotonergic regulation of appetite @MolMetab . We identified LH and BNST as relevant targets where optogenetic activation of dorsal raphe nucleus (DRN) sert+ projections suppresses feeding. 🧵
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@AtasoyLab
Deniz Atasoy
10 months
Opioids are generally known to promote hedonic appetite. Since most of the existing studies focused on mesolimbic reward circuits, the role of hypothalamic opioid signaling in appetite regulation remains unclear. In a new study from the lab we found that++
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@AtasoyLab
Deniz Atasoy
1 year
Direct ghrelin action on NOS1-expressing PVH neurons causes nitric oxide-mediated stimulation of HPA axis. We are happy to make a small contribution to this study led by @NeurophysioLab .
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@AtasoyLab
Deniz Atasoy
9 months
Excited to share the latest work from the lab @npp_journal . We examined activity dynamics of NTS catecholamine->PVN input in response to various stressors and showed that resulting inhibition of downstream PVN-MC4R neurons conveys negative valence.
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@AtasoyLab
Deniz Atasoy
1 year
We are pleased to be a part of this exciting study, led by Justin Grobe, describing a molecular mechanism for obesity-associated dysregulation in resting metabolic rate (RMR),through a switch in Ang-II receptor pathway in AgRP neurons.Congrats to all team.
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@AtasoyLab
Deniz Atasoy
5 years
Our latest paper on appetite regulation by hypoglycemia is out.
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@AtasoyLab
Deniz Atasoy
4 years
After getting the actual printed issue in mail, I just realized that an image from our MCH paper made it to the cover of Neuroendocrinology!
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@AtasoyLab
Deniz Atasoy
2 years
Pleased to share our Preview with twitterless Connor Laule on the exciting work by Grzelka et al. describing hunger amplified synaptic drive onto AgRP neurons. Congratulations to @FenselauHenning and the team.
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@AtasoyLab
Deniz Atasoy
1 year
Sending off two fantastic summer students, Gulnihan Simsek and Defne Bayman. It was great to have you both.
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@AtasoyLab
Deniz Atasoy
1 year
If you are interested in catecholamine and opioid dependent appetite-satiety & stress regulation, we will have 3 posters at SfN 2023 starting from tomorrow afternoon.
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@AtasoyLab
Deniz Atasoy
2 years
Lunar eclipse from the Midwest.
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@AtasoyLab
Deniz Atasoy
2 years
Tuesday morning Atasoy Lab poster at #SfN2022 482.10 / QQ6 "Dorsal Raphe Serotonergic Neurons Suppress Feeding Through Redundant Forebrain Circuits" by Iltan Aklan.
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@AtasoyLab
Deniz Atasoy
1 year
"...Activating Trh(Arc) neurons inhibits AgRP neurons and decreases feeding in an AgRP neuron-dependent manner. Silencing Trh(Arc) neurons increases feeding and body weight and reduces liraglutide’s satiating effects..."
@biorxiv_neursci
bioRxiv Neuroscience
1 year
Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety #biorxiv_neursci
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@AtasoyLab
Deniz Atasoy
1 year
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@AtasoyLab
Deniz Atasoy
10 months
3/ Our data suggest that, unlike their appetite promoting actions in reward pathways, opioids may contribute to satiety after eating via tonic AgRP-neuron inhibition. This work was jointly led by @nillysayar and @yavuzyavuz1712 , in collaboration with @LinTianPhD lab and others.
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@AtasoyLab
Deniz Atasoy
1 year
“Caution must especially be exercised when the observed phenotype closely matches that of lesions in the area of use.Ensuring that expression in wild-type mice results in no observable changes or that neuronal cell densities are unaltered are two such methods of validating (AAV)”
@biorxiv_neursci
bioRxiv Neuroscience
1 year
Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus #biorxiv_neursci
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@AtasoyLab
Deniz Atasoy
1 year
Surprisingly, long term variations in AgRP neuron activity were not fully consistent with their assumed role as an energy homeostat -activated by hunger and silenced by feeding-. Instead, chronic AgRP neuron activity oscillated in parallel with past circadian feeding experience++
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@AtasoyLab
Deniz Atasoy
2 years
Wednesday morning Atasoy Lab poster at #SfN2022 648.05/PP13 "Convergent modulation of feeding and stress by an ascending catecholamine pathway" Describing the gating of presynaptic release onto PVN-MC4R neurons by dorsal medullary adrenergic input. Presented by Connor Laule.
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@AtasoyLab
Deniz Atasoy
2 years
We are pleased to have made a small contribution to this exciting study led by Rory Fisher and colleagues. @IowaNeuroPharm , @UIowaNeuro
@biorxiv_neursci
bioRxiv Neuroscience
2 years
RGS6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in an Alzheimer's mouse model #biorxiv_neursci
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@AtasoyLab
Deniz Atasoy
4 years
Congrats @NChanaday and the whole team! We are also proud to have contributed to this insightful work.
@NChanaday
Natalí Chanaday
4 years
I'm extremely happy to announce that our project studying Store Operated Calcium Entry at presynaptic terminals is finally published!! We asked whether SOCE can regulate neurotransmitter release and how. See thread for details and cool findings!! 1/n
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@AtasoyLab
Deniz Atasoy
2 years
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@AtasoyLab
Deniz Atasoy
3 years
@HHMIJanelia Looks like mug-stacking system has been upgraded...
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@AtasoyLab
Deniz Atasoy
3 years
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@AtasoyLab
Deniz Atasoy
1 year
..such that AgRP activity was higher at the times of day when feeding occurred in recent past and lower at other times. For free feeding mice this was dark cycle and required intact SCN or light cue whereas for time restricted feeding this rise required DMH prodynorphin neurons++
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@AtasoyLab
Deniz Atasoy
10 months
2/ hypothalamic opioid levels surge after feeding, which, in turn, inhibit AgRP neurons through Mu-Opioid-Rs. MOR agonist DAMGO suppressed AgRP synaptic output and excitatory input onto them. We also uncovered conditional sensitivity to b-arrestin pathway inhibitors++
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@AtasoyLab
Deniz Atasoy
1 year
Rhythmic AgRP activation based on past experience could be an adaptation to ensure foraging in times of day during which successful feeding occurred in the past and to avoid it when it is futile or dangerous in an environment with rhythmic food availability.
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@AtasoyLab
Deniz Atasoy
1 year
These findings suggest that rather than classical homeostatic feedback regulation, AgRP-dependent hunger is more consistent with allostatic regulation in which AgRP activity changes in anticipatory fashion based on learned cues, in this case circadian time itself acting as a cue.
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@AtasoyLab
Deniz Atasoy
4 years
Congratulations to @ronggong1 and @BrainCaRMA Lab team, elegantly showing a hindbrain double negative feedback loop required for sustained consumption.
@BrainCaRMA
Scott Sternson
4 years
See our new study in @CellCellPress , led by @ronggong1 . She showed that neurons in the peri-locus coeruleus (periLC) are important for palatability-driven consumption of both food and water.
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@AtasoyLab
Deniz Atasoy
1 year
...and here is the link for free access to the article:
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@AtasoyLab
Deniz Atasoy
2 years
We also found 5HT levels and DRNsert axonal activity in LH and BNST increase with food and metabolic hormones. Finally, we showed that 5HT not only directly acts on LH neurons but can also presynaptically suppresses GABA release from AgRP axons, causing disinhibition.
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@AtasoyLab
Deniz Atasoy
5 years
Looking forward to Dr. Friedman's talk at University of Iowa! @IowaMed
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@AtasoyLab
Deniz Atasoy
1 year
This work was led by @nillysayar and Connor Laule in the lab and is now out at @NatureComms
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@AtasoyLab
Deniz Atasoy
1 year
@MunirGunesKutlu Lasers from Doric. 4 independent channels of 450nm (~80mW each) was around $5k a few years ago, comes in as turn-key, no need for alignment.
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@AtasoyLab
Deniz Atasoy
5 years
Visit our poster at board U12 today, between 8 am and 12 pm, at #SFN19 . Nilly is presenting our work on MCH neuron activity and reward! @Neurosci2019 @SfNtweets @UIowaNeuro @uiowa
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@AtasoyLab
Deniz Atasoy
5 years
We are presenting at #SFN19 ! You can visit our posters on Tuesday afternoon at Board T1, and on Wednesday morning at Board U12. @Neurosci2019 @SfNtweets @UIowaNeuro
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@AtasoyLab
Deniz Atasoy
1 year
This work also provides context for the orexigenic role of norepinephrine, which was first described by P.S. Grossman >60 years ago.
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@AtasoyLab
Deniz Atasoy
4 years
Congratulations Scott and the team! Can't wait to read it.
@BrainCaRMA
Scott Sternson
4 years
Our new study in @ScienceMagazine , led by @shengjin_xu . We report CaRMA imaging-- a method that combines deep-brain in vivo single neuron dynamics in mice with detailed gene co-expression information in the same cells across multiple behavioral states.
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@AtasoyLab
Deniz Atasoy
2 years
This work was in collaboration with @yulonglilab , and builds upon earlier findings from @cpnoct , @LoraHeisler , @DrYongXu1 , @marcschp @ChenLiuLab and others.
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@AtasoyLab
Deniz Atasoy
5 years
@nilyapici Same here.
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@AtasoyLab
Deniz Atasoy
2 years
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@AtasoyLab
Deniz Atasoy
1 year
@yaksi_emre Nice shot, I used to take this road every day.
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@AtasoyLab
Deniz Atasoy
2 years
@michael_krashes @AmesSutton Congrats Mike & the whole team, great work!
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@AtasoyLab
Deniz Atasoy
3 years
@TomchikLab @UIowaNeuro @NeuroIowa @UIowaPeds Congrats Seth! Looking forward to working with you.
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@AtasoyLab
Deniz Atasoy
1 year
@OferYizhar Once the judiciary is gone, nothing can stop the downhill spiral, just look at Turkey.
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@AtasoyLab
Deniz Atasoy
10 months
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@AtasoyLab
Deniz Atasoy
11 months
@zane_andrews1 This is a really great write up Zane, it covers all the bases and more.
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@AtasoyLab
Deniz Atasoy
1 year
@OferYizhar Very sorry to hear what is happening, stay safe.
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@AtasoyLab
Deniz Atasoy
1 year
@MPFNeuro @LinTianPhD Great news, congratulations Lin!
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@AtasoyLab
Deniz Atasoy
4 years
@AshleyIngiosi @CurrentBiology @Inscopix Congratulations, really beautiful video. Is that a capillary running through middle? Its baseline fluorescence levels seem to be responding as well..
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@AtasoyLab
Deniz Atasoy
2 years
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@AtasoyLab
Deniz Atasoy
2 years
@hardawayja I got the same response from Alz Foundation last year.
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@AtasoyLab
Deniz Atasoy
9 months
These results confirm earlier cFos studies and provide insight into the role of non-HPA axis targets of ascending catecholamine fibers in stress response. This work was led by Connor Laule, a talented graduate student. Free full text can be accessed at:
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@AtasoyLab
Deniz Atasoy
3 years
@NChanaday @UPennPhysiology Congratulations Natali!
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@AtasoyLab
Deniz Atasoy
2 years
Does anyone know a commercial source for AAV-CREoff-ChR2 (or a similar activating opsin) virus? All the available CREoff virus seems to be in combination with FLPon/off.
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@AtasoyLab
Deniz Atasoy
11 months
@LisaMonteggia Thank you Lisa.
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@AtasoyLab
Deniz Atasoy
1 year
@TheBurro34 @Jacob51522931 Nope, he clearly did not have control.
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@AtasoyLab
Deniz Atasoy
2 years
@bridge_balance_ "Wire-free" as in wi-fi access to the recorded feeding data?
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@AtasoyLab
Deniz Atasoy
3 years
@AshleyIngiosi @NIH Congrats Ashley!
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@AtasoyLab
Deniz Atasoy
3 years
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@AtasoyLab
Deniz Atasoy
2 years
@VUBasicSciences @LisaMonteggia Congratulations Lisa & Ege!
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@AtasoyLab
Deniz Atasoy
1 year
@Yippocampus Great question, unfortunately our protocol does not permit doing this since food deprivation for such a long period would be too extreme for mice. Perhaps a more hunger resilient animal model would be more appropriate to address this.
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@AtasoyLab
Deniz Atasoy
4 years
@ChubykinLab Congrats Alex!
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@AtasoyLab
Deniz Atasoy
4 years
@LisaMonteggia I am very sorry to hear this Lisa, my deepest condolences to you and Ege.
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