Abstract. Ageing is a complex and multifactorial process. For two decades, the Human Ageing Genomic Resources (HAGR) have aided researchers in the study of

Nature Reviews Nephrology - Cellular senescence has beneficial functions in embryonic development, wound healing and tumour suppression but can also be maladaptive, contributing to cancer...

Nature Communications - Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine...

Aging | doi:10.18632/aging.204248. Tomas Schmauck-Medina, Adrian Molière, Sofie Lautrup, Jianying Zhang, Stefan Chlopicki, Helena Borland Madsen, Shuqin Cao, Casper Soendenbroe, Els Mansell, Mark...

Signal Transduction and Targeted Therapy - Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Taurine supplementation extends healthy lifespan in worms, rodents, and non-human primates.

Pluripotent stem cells (PSCs) can self-renew indefinitely in culture while retaining the potential to differentiate into virtually all normal cell types in the adult animal. Due to these remarkable...

Nature Reviews Molecular Cell Biology - Nicotinamide adenine dinucleotide (NAD+) is a central redox factor and enzymatic cofactor that functions in a plethora of cellular processes, including...

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously across different species and spans several orders of magnitude in vertebrates alone. This vast phenotypic divers...

There's one major key to unlocking extreme longevity.

Signal Transduction and Targeted Therapy - Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Now, physicians will soon be able to prescribe an approved drug shown in clinical trials to decrease the rate of mortality by 60 percent and prolong lives by an average of two and a half years.

Longo and Anderson synthesize and weigh the literature, from molecular mechanisms to epidemiology and spanning yeast to people, about what you should eat, how much you should eat, and when should you...

Nature Communications - The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, the authors show that the...

Nature Communications - The development of human cellular models of aging that surpass the limitations of animal models of aging is urgent. Here, the authors explore the opportunities and...

But doubts remain about whether cell reprogramming technique could one day help humans

Nature Aging - Urolithin A (UA) is a gut microbiome-derived metabolite that has been therapeutically explored in aging-related diseases and exerts its benefits in part through effects on...

Ethereum creator Vitalik Buterin has sold a range of dog-themed tokens he was given for free, swapping them for more ether.

GeroScience - Aging is a gradual and irreversible process that is accompanied by an overall decline in cellular function and a significant increase in the risk of age-associated disorders....

Nature Aging - This Perspective describes and discusses the Information Theory of Aging, which proposes that aging primarily stems from the loss of youthful epigenetic information that can be...

We used two types of epigenetic information—DNA methylation (DNAm), and chromatin accessibility as measured by ATAC-seq—to develop age predictors in peripheral blood mononuclear cells sampled from a...

Nature Aging - Epigenetic clocks can measure biological aging, but the relationship between epigenetic age and other hallmarks of aging is incompletely understood. Here the authors show that...

Aging is concomitant with a slew of molecular changes, including significant shifts in the epigenome. These age-related alterations can be used to construct aging clocks, which are computational...

US findings suggesting ageing is not a slow and steady process could explain spikes in health issues at certain ages

Cellular ageing described at the molecular level is a multifactorial process that leads to a spectrum of ageing trajectories. There has been recent discussion about whether a decline in physicochem...

Signal Transduction and Targeted Therapy - Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging

Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently unde...

Signal Transduction and Targeted Therapy - Epigenetic regulation of aging: implications for interventions of aging and diseases

Increasing studies have captured the heterogeneity of the ageing process and introduced the concept of “biological age”. This review provides a comprehensive summary of currently identified ageing...

Aging is a complex process that features a functional decline in many organelles. Various factors influence the aging process, such as chromosomal abnormalit...

In this study, we examined the relation between physical activity and epigenetic ageing in 3567 eligible participants of a large community-based, prospective cohort study, the Rhineland Study. We...

Aging is associated with an impairment in stem cell function and several strategies for stem cell rejuvenation have been proposed: exercise, dietary restriction, reprogramming, senolytics, increasi...

Nature - Humans also have the protein, called IL-11, offering hope for a future longevity treatment.

Using samples from the CALERIE™ study, we demonstrate that calorie restriction (CR) significantly reduced the concentrations of several circulating biomarkers of cellular senescence compared to an...

Nature - New research identifies some of the genes that could help to explain why lung cancer incidence rises with age but declines after the age of 75.

Nature - Researchers are using new molecules, engineered immune cells and gene therapy to kill senescent cells and treat age-related diseases.

Nature Aging - This comprehensive resource offers new insights into how different types of cell and tissue change with age in C. elegans and unveils the distinctive anti-aging effects of various...

This review focused on the applications and limitations of major senescence biomarkers, including senescence-associated β-galactosidase staining, telomere shortening, cell-cycle arrest, DNA methyla...

Aging is characterized by changes in cellular identity and function over time. This process is driven by changes in chromatin factor localization during DNA break repair, which alters the epigenome...

Using transcriptomic analysis and chromatin accessibility assays, Rasa et al. identify the multi-tissue gene network regulating inflammaging. These effects can be partially reversed via dietary...

Tao et al. developed a computational program that identifies and tracks 6 types of senescent cells based on single-cell transcriptomes from tens of thousands of cells.

Nature - Harmful effects of ageing slowed by inhibiting an inflammatory cytokine.

Abstract. Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chr

Abstract. Multiple changes occur in hormonal regulation with aging and across various endocrine organs. These changes are associated with multiple age-rela

Nature Aging - Senescent cells are typically identified by a combination of senescence-associated markers, and the phenotype is heterogeneous. Here, using deep neural networks, Heckenbach et al....

Epigenetic aging is accellerated in cells living in an older body compared to cells living in a younger body.

Nature Cell Biology - Biological clocks can be used to evaluate the age of a cell or organisms. This Perspective proposes the concept of an intrinsically disordered protein (IDP) clock, whereby the...

Jeff Bezos has backed anti-aging startup Alto Labs, which has recently hired former chief scientific officer of GlaxoSmithKline Hal Barron as its CEO.

Among the goals of the group, called the Academy for Health and Lifespan Research, are to share findings and lobby governments in the United States, Europe, and elsewhere to increase funding and...

Nature Reviews Nephrology - Perturbations in the regulation of gene expression can contribute to disease- and ageing-associated changes in cell physiology. This review describes how the...

Aging is linked to a time-associated decline in both cellular function and repair capacity leading to malfunction on an organismal level, increased frailty, ...

Nature Communications - Identifying senescence is complicated by a lack of universal markers. Here, Duran et al. use nuclear morphology features to devise machine-learning classifiers that detect...

Choudhury et al. report that senescent cells exhibit diminished proline biosynthesis and benefit from proline supplementation. Proline promotes mitophagy by activating AMPKα and upregulating Parkin,...

npj Aging - Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients’ treatment

Abstract. Limited evidence exists on the link between inflammation and epigenetic aging. We aimed to (a) assess the cross-sectional and prospective associa

Long life requires individuals to defend themselves against pathogens over prolonged periods of time whilst minimising damage to themselves. In vertebrates, pathogen defence is provided by two...

Abstract. The Open Genes database was created to enhance and simplify the search for potential aging therapy targets. We collected data on 2402 genes assoc

Circulating components of the (SASP) have been studied as biomarkers of senescent cell burden. We hypothesized that senescence biomarker levels could predict mortality even in healthy older adults....

The inexorability of the aging process has sparked the curiosity of human beings since ancient times. However, despite this interest and the extraordinary sc...

Two years of sustained CR in humans positively affected skeletal muscle quality, and impacted gene expression and splicing profiles of biological pathways known to affected by CR in model organisms....

The review “Cellular senescence and gut microbiome alterations” by J. Dong-Hyun et al. demonstrates that gut microbiome dysbiosis and cellular senescence interact bidirectionally and contribute...

The current study shows that the accumulation of senescent brain endothelial cells (BECs) may mediate the transition from a young to an aged BBB. Aged BECs have a higher expression of senescent...

Nature Metabolism - Kovatcheva et al. show that vitamin B12 improves the efficiency of in vivo reprogramming and tissue repair through its functions in one-carbon metabolism and epigenetic modulation.

Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contribu...

Supercentenarians and semi-supercentenarians – people who reach the ages of 110 and 105 – have genes that reduce the number of mutations that accumulate in their cells

We utilize two large atlases of single cell PBMC expression to illustrate decline in marker identity with age in humans across multiple cell types. This is largely due to increasing variability...

Aging | doi:10.18632/aging.204896. Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen,...

Nature Aging - Large-scale proteomics data hold promise for individual disease risk prediction. Here the authors use data from more than 50,000 adults without dementia in the UK Biobank to predict...

The evolutionary theory of aging has set the foundations for a comprehensive understanding of aging. The biology of aging has listed and described the “hallm...

This review delineates the molecular hallmarks of cellular senescence and examines whether they are evident in aging-associated T cells referred to as immunosenescent T cells and exhausted T cells.

Aging | doi:10.18632/aging.203736. Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, Francis R. Palmer, Brian K. Kennedy, Yelena V. Budovskaya

Using a specific approach to the selection of experimental groups, this study demonstrated the distinct role of primary and secondary aging in the regulation of transcriptomic and proteomic profiles...

This randomized controlled trial finds that one month of high-intensity interval training can reduce an mRNA-based measure of biological age in sedentary adults ages 40–65 compared with a no-exerci...

npj Regenerative Medicine - Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice

XPRIZE Healthspan is a 7-year, $101 million global competition to revolutionize the way we approach human aging.

Nature Communications - Understanding how the immune system’s functionality declines with age is crucial for addressing aging-related health issues. Here, the authors demonstrate that...

Decreased translational accuracy shortens life span and accelerates the onset of age-related phenotypes in mammals.

Telomere shortening is one of the main causes of cellular senescence. Caffeine is a natural stimulant most commonly found in coffee and tea. In this study, caffeine was found to promote the express...

How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the ...