Alistair Sterling @ASterlingChem Twitter profile

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Alistair Sterling

@ASterlingChem

5 months

In August I will be joining @UTDallasChemBio to start my research group! Thank you to many ( @duarte_group , @EdAndersonGroup , @mhg_group , ...) for your support. You can find out about my group's plans here: More very soon... @UT_Dallas @UTDScience

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Alistair Sterling

@ASterlingChem

3 months

***We are hiring!*** My group is looking for a postdoc with comp chem experience to join us at @UTDallasChemBio from August '24. You can find out more about the position and submit your application here: Please share! #compchem

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Alistair Sterling

@ASterlingChem

9 months

Check out "Mechanistic insights into the origins of selectivity in a Cu-catalyzed C–H amidation reaction", now on @ChemRxiv (). My second contribution as part of the @mhg_group , with beautiful kinetics from Nico Ciccia and Yifan Guo from the @HartwigGroup

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Alistair Sterling

@ASterlingChem

5 years

Understanding the electronic structure and reactivity of [1.1.1]propellane to develop new routes to bicyclo[1.1.1]pentanes #RSCPoster #RSCOrg

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Alistair Sterling

@ASterlingChem

7 months

Delighted to share the published version of this work, out now in @J_A_C_S ! Huge thanks to Nico Ciccia and Yifan Guo for their great work @HartwigGroup @mhg_group @UCB_Chemistry @BerkeleyLab #compchem

Mechanistic Insights into the Origins of Selectivity in a Cu-Catalyzed C–H Amidation Reaction

The catalytic transformation of C–H to C–N bonds offers rapid access to fine chemicals and high-performance materials, but achieving high selectivity from undirected aminations of unactivated...

pubs.acs.org

Alistair Sterling

@ASterlingChem

9 months

Check out "Mechanistic insights into the origins of selectivity in a Cu-catalyzed C–H amidation reaction", now on @ChemRxiv (). My second contribution as part of the @mhg_group , with beautiful kinetics from Nico Ciccia and Yifan Guo from the @HartwigGroup

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Alistair Sterling

@ASterlingChem

4 years

My entry to the #RSCPoster Twitter conference: How an understanding of electron delocalisation in strained molecules can be used to guide the synthesis of caged compounds for drug discovery. (1/6)

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Alistair Sterling

@ASterlingChem

2 years

After 8 years I'm sadly saying goodbye to Oxford. Thank you to all who made my time here so special, especially @fjduarteg , @EdAndersonGroup , and too many others to mention here. Looking forward to my next adventure in Berkeley with the @mhg_group !

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Alistair Sterling

@ASterlingChem

4 years

Thrilled to share the published version of this work in @ChemicalScience !

Duarte Group

@duarte_group

4 years

Excited to share that Alistair's ( @ASterlingChem ) work on the electronic structure and reactivity of [1.1.1]propellane has just been accepted for publication in @ChemicalScience ! You can read the open-access article here: #compchem

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Alistair Sterling

@ASterlingChem

5 months

Delighted to share that our work on nodes, kinetic energy and chemical bonding is out now in @J_A_C_S ! @mhg_group #compchem @UCBerkeley @UCB_Chemistry @BerkeleyLab

Chemical Bonding and the Role of Node-Induced Electron Confinement

The chemical bond is the cornerstone of chemistry, providing a conceptual framework to understand and predict the behavior of molecules in complex systems. However, the fundamental origin of chemical...

pubs.acs.org

Alistair Sterling

@ASterlingChem

1 year

My first contribution as part of the @mhg_group attempts to answer tricky questions surrounding the origins of the chemical bond. You can read it on @ChemRxiv here: #compchem @UCBerkeley @UCB_Chemistry @BerkeleyLab (1/3)

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Alistair Sterling

@ASterlingChem

1 year

My first contribution as part of the @mhg_group attempts to answer tricky questions surrounding the origins of the chemical bond. You can read it on @ChemRxiv here: #compchem @UCBerkeley @UCB_Chemistry @BerkeleyLab (1/3)

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Alistair Sterling

@ASterlingChem

4 years

Thanks to the organisers of #OSSC2020 for giving me the opportunity to present my research alongside great talks from the other speakers!

Ed Anderson Group 🇺🇦

@EdAndersonGroup

4 years

@ASterlingChem presents his work on the reactivity of [1.1.1]propellane at #OSSC2020 . Find out more about his work in @ChemicalScience here: @OxfordSynthesis @duarte_group

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Alistair Sterling

@ASterlingChem

3 years

Delocalisation can be used hand in hand with strain release to both understand and predict the reactivity of organic molecules. Very happy to be able to share the central ideas developed during my PhD: #compchem

Duarte Group

@duarte_group

3 years

Reactions that release strain energy are found everywhere in chemistry, but the link between strain and reactivity doesn’t hold for even simple systems, e.g. cyclopropane, cyclobutane and [1.1.1]propellane release similar strain energy, but reactivity differs hugely. (1/5)

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Alistair Sterling

@ASterlingChem

4 years

Really happy to have been selected to attend the Global Young Scientists Summit in January 2021 - looking forward to meeting and learning from eminent scientists and early-career academics from around the world #GYSS

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Alistair Sterling

@ASterlingChem

5 years

Exploring the reactivity of [1.1.1]propellane through computation - my second contribution to @ChemRxiv ! Huge thanks to @fjduarteg , @EdAndersonGroup and Russell Smith from @JanssenUS ! #propellanenightmares

ChemRxiv

@ChemRxiv

5 years

Straining to React: Delocalization Drives the Stability and Omniphilicity of [1.1.1]propellane by Alistair Sterling, Russell C. Smith, Edward Anderson & Fernanda Duarte

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Alistair Sterling

@ASterlingChem

4 years

A new method for small molecule chemical space screening that uses ML to balance the accuracy of 3D force field simulations with the speed of 2D heuristics: A collaboration between @OxUniMaths , @OxfordStats and @OxfordChemistry / @OxfordSynthesis #compchem

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Alistair Sterling

@ASterlingChem

4 years

Had a great time working on this project with @romain_costil and @JonathanClayden - using a combination of MD / DFT (by @fjduarteg ), NBO, coupled cluster calculations, and a predictive model based on Charton steric parameters to understand the origins of atropisomerism #compchem

Duarte Group

@duarte_group

4 years

Excited to share our work in collaboration with @romain_costil and @JonathanClayden , where we investigate atropisomerism in diarylamines. Just published in @angew_chem - congratulations @ASterlingChem ! #compchem @OxfordSynthesis @OxfordChemistry

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Alistair Sterling

@ASterlingChem

10 months

Interested in chemical bonding? Check out this @ChemistryWorld collection featuring an opinion piece on my recent work with @mhg_group about the importance of orbital nodes ()

Chemistry World

@ChemistryWorld

10 months

Perhaps what we need is a unified theory of bonding? @ASterlingChem and @mhg_group take a dive into that significant challenge.

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Alistair Sterling

@ASterlingChem

5 years

Updated preprint of our work on [1.1.1]propellane - just hit 2000 article views and >500 downloads! If you're interested in the interplay between electron correlation and symmetry, and how this defines the behaviour of a strange but surprisingly useful molecule, have a read!

ChemRxiv

@ChemRxiv

5 years

Rationalizing the diverse reactivity of [1.1.1]propellane through sigma-pi-delocalization by Fernanda Duarte & co-workers

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Alistair Sterling

@ASterlingChem

4 years

Excited to share our review of advances in computational techniques for the prediction of selectivity in organocatalysis. We track the evolution of the field from transferrable empirical models, through to accurate QM simulations, and onwards to descriptor-based ML models.

Duarte Group

@duarte_group

4 years

Our review on developments in predictive models for organocatalysis is out now in @WIREs_Reviews - covering the state of the art in the field from early qualitative models to QM and ML descriptor-based predictive models.

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Alistair Sterling

@ASterlingChem

5 years

This is great! Thanks @ErrantScience for the cartoonification!

ErrantScience

@ErrantScience

5 years

Today thanks to @ASterlingChem 's #RSCOrg #RSCPoster I learnt about the wonderful [1,1,1]propellane's love of holding hands #CartoonAbstract

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Alistair Sterling

@ASterlingChem

3 months

Great to see this work in its final form! Sadly perhaps my final mechanistic study with @Jeremy__Nugent #compchem

Ed Anderson Group 🇺🇦

@EdAndersonGroup

3 months

Delighted to publish our latest BCP/BCHep paper on alpha-amino bicycloalkylation in @ChemicalScience . Congratulations to the team, esp. @Jeremy__Nugent , @ASterlingChem and @AdrianLopezFra . See:

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Alistair Sterling

@ASterlingChem

4 years

Shocked and disgusted by the now infamous "article" published by @angew_chem . We privileged majority have to stand up to this blatant sexism and racism, and support our friends and colleagues who experience this every day. I can't begin to imagine the emotional burden.

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Alistair Sterling

@ASterlingChem

5 years

Kayaking trip at the Phys Org GRC, including ospreys and a bald Eagle - thanks to Marcel Strauss for the photos

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Alistair Sterling

@ASterlingChem

5 years

Really pleased to see this work on the multiple ionisation and dissociation channels of isocyanic acid in @SciReports !

Double and Triple Ionisation of Isocyanic Acid

Scientific Reports - Double and Triple Ionisation of Isocyanic Acid

www.nature.com

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Alistair Sterling

@ASterlingChem

2 years

Congrats @1999Nils and the team! I'm lucky to have worked with such talented people, especially Nils for his tireless synthetic and computational work. It's really rewarding to see a prediction from my PhD on 111P vs 311P reactivity turn into something so exciting #compchem

Ed Anderson Group 🇺🇦

@EdAndersonGroup

2 years

Excited to share a new meta-arene #bioisostere , the BCHep, out today in @Nature . Congrats to the team: @1999Nils , @Jeremy__Nugent , @BethanyShire , @helenapickford and our collaborators @fjduarteg , @SchofieldOxford , @GroupBrennan and @abbvie . See:

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Alistair Sterling

@ASterlingChem

4 years

"Attending" the Small Organic Molecules day from the comfort of my kitchen - very interesting talks so far from @reymondgroup and Markus Meringer. Live stream is here: #compchem

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Alistair Sterling

@ASterlingChem

5 years

Congratulations @LorelScriven and @GawelPrzemyslaw - awesome work! Cyclocarbon is here! @HLAGroupOx

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Alistair Sterling

@ASterlingChem

3 years

Exciting new work on selective chloride transport using XB and ChB donors from the @ChemLangton group, Beer group and @duarte_group ! #compchem @OxfordSynthesis @OxfordChemistry

Langton Research Group

@ChemLangton

3 years

Our recent work on anion transport using sigma hole interactions is out in @ChemEurJ , in collaboration with @fjduarteg and Beer groups. Congratulations to @LauraEBickerton , Andrew, @ASterlingChem and @LookingforHeike ! @OxfordChemistry @OxfordSynthesis

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Alistair Sterling

@ASterlingChem

5 years

Making BCPs from TCP with photoredox catalysis, first in @ChemRxiv , and out now in @ACSCatalysis ! My first paper as a computational chemist - thanks to @fjduarteg ! @OxfordSynthesis #compchem

Ed Anderson Group 🇺🇦

@EdAndersonGroup

5 years

A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis

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Alistair Sterling

@ASterlingChem

4 years

Great to see this work in @ChemicalScience ! Our first publication from an enjoyable and exciting collaboration between @ChemLangton and @duarte_group

Langton Research Group

@ChemLangton

4 years

Very pleased to share our first publication on supramolecular transmembrane ion transporters - and the first from our collaboration with @duarte_group . Congrats to Laura Bickerton and @ASterlingChem ! @ChemicalScience @OxfordChemistry @OxfordSynthesis

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Alistair Sterling

@ASterlingChem

5 years

Thanks to the organisers of #YMF2019 for a great conference! A lot of exciting research on show

Duarte Group

@duarte_group

5 years

Congratulations to Alistair ( @ASterlingChem ) who won a prize for his talk on the reactivity of [1.1.1]propellane at the Young Modellers Forum 2019! Great collaborative work with @EdAndersonGroup @OxfordSynthesis @OxfordChemistry @JanssenUS

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Alistair Sterling

@ASterlingChem

5 years

Our perspectives on the field of C-H fluorination with @GouverneurGroup in @angew_chem

Angewandte Chemie

@angew_chem

5 years

The Fluorination of C-H Bonds: Developments and Perspectives (Gouverneur)

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Alistair Sterling

@ASterlingChem

1 year

If you're at #ACS Fall this week and interested in physical organic chemistry, possible origins of covalent bonding, or organometallic chemistry, I'll be talking about each of these topics (1/4)

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Alistair Sterling

@ASterlingChem

5 years

Arrived in Boston for my first #GRC @GordonConf on Physical Organic Chemistry - looking forward to a great week of cool research!

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Alistair Sterling

@ASterlingChem

3 years

Excited to share a new method for the asymmetric synthesis of BCPs from [1.1.1]propellane and simple aldehydes using photoredox organocatalysis! #compchem (1/4)

Ed Anderson Group 🇺🇦

@EdAndersonGroup

3 years

Check out our latest work in the BCP arena: asymmetric radical additions to [1.1.1]propellane via organo/photoredox catalysis, out in @NatureComms , . Congrats Marie and @ASterlingChem , a great collaboration with @fjduarteg @OxChemRF and @J2_Mousseau

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Alistair Sterling

@ASterlingChem

4 years

Thanks to Tristan ( @Tristan81946826 ) for creating such cool cover art! Great to have this research featured in @ChemicalScience

Chemical Science

@ChemicalScience

4 years

Rationalizing the diverse reactivity of [1.1.1]propellane through σ–π-delocalization by Edward A. Anderson, Fernanda Duarte et al. is on our back cover this week 😃 Read it here 👉 #ChemSciCovers

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Alistair Sterling

@ASterlingChem

4 months

Fantastic to see our work appreciated by the organic chemistry community - thanks and congrats to all involved!

Bull Group Chemistry

@jamesabull

4 months

Delighted that this work has received such a recognition from JOC! It was a fun project in fundamental organic chemistry with excellent coworkers and collaborators @dubois_maryne , @JR_Chemistry , @ASterlingChem , @fjduarteg , @J2_Mousseau , and the rest of team!

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Alistair Sterling

@ASterlingChem

5 years

@joaquinbarroso In many cases, B3LYP is certainly adequate. The problem is that without a benchmark study, there is no way of knowing when it gives an answer that is qualitatively wrong. This is of course not unique to B3LYP. Benchmarking is good science.

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Alistair Sterling

@ASterlingChem

5 years

Excited to see our new paper on photoredox C-C sigma bond activation on @ChemRxiv !

ChemRxiv

@ChemRxiv

5 years

Visible Light Promoted Functionalisation of Carbon-Carbon Sigma Bonds by Fernanda Duarte, Edward Anderson & co-workers #organicchempreprints

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Alistair Sterling

@ASterlingChem

6 years

Excited to share this @angew_chem Review on the development of C-H fluorination methods, in collaboration with @GouverneurGroup

The Fluorination of C−H Bonds: Developments and Perspectives

The direct fluorination of C−H bonds has emerged as a powerful method for accessing functional molecules such as pharmaceuticals or PET radiotracers. This Review provides an overview of the state of...

onlinelibrary.wiley.com

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Alistair Sterling

@ASterlingChem

2 years

Always fun working with Juan and the team figuring out some interesting reactivity of cool molecules! Our most recent Chemrxiv is here: #compchem

Juan J. Rojas

@JR_Chemistry

2 years

a „quick project“ that turned into a huge study on the reactivity of strained radicals and benzylic radicals in general. Learned loads of fundamental chemistry along the way too🤓 It was great fun to work again with @ASterlingChem and @fjduarteg

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Alistair Sterling

@ASterlingChem

4 years

Congratulations to everyone involved in the project!

Lorel Scriven

@LorelScriven

4 years

Excited to share with you more of our work on cyclo[18]carbon as part of our collaboration with @IBMResearch . Just accepted in @J_A_C_S : Synthesis of cyclo[18]carbon via debromination of C18Br6. @ASterlingChem @GawelPrzemyslaw #cyclocarbon #realtimechem

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Alistair Sterling

@ASterlingChem

5 years

At the Phys Org GRC with @michal_juricek @UZH_Chemistry wish you were here @MichelRickhaus

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Alistair Sterling

@ASterlingChem

2 years

Enjoyed connecting this cool reaction to an interesting manifestation of Bent's rule - always fun to work with @JR_Chemistry and co! #compchem

J Org Chem/Org Lett

@JOC_OL

2 years

Benzylic oxetane and azetidine radicals generated by photocatalysis undergo an irreversible Giese-type reaction where typical unstrained benzylic radicals add reversibly. In #JOrgChem from @dubois_maryne @JR_Chemistry @ASterlingChem @fjduarte @jamesabull

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Alistair Sterling

@ASterlingChem

2 years

@TYoungResearch However you like - as long as your definition lets you to make predictions of behaviour for a wide range of diverse systems (perhaps?) Exceptions can be found for every rule when not dealing with observables, but if the rule is useful 99% of the time then why throw it out?

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Alistair Sterling

@ASterlingChem

6 years

Arrived in Helsinki for the 34th Winter School in Theoretical Chemistry - time for some machine learning!

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Alistair Sterling

@ASterlingChem

4 months

Very well deserved - talented, hard-working, and selfless in equal measures

Martin Head-Gordon Group

@mhg_group

4 months

Huge congrats to our group's undergrad Anthony Lara for winning the George C Pimentel Award for outstanding undergraduate research!

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Alistair Sterling

@ASterlingChem

4 years

Celebrating in style the only way we know how: with a caterpillar cake

Thomas Robinson

@nosnibor_mot

4 years

Happy to say I have passed my DPhil viva, and am grateful to @benwansell and Jim Snyder for their super helpful comments. Enormous thanks to @aeggers for his patient guidance, and to many others who helped me along the way. Excited to join colleagues at @Durham_SGIA from Aug.!

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Alistair Sterling

@ASterlingChem

4 years

You can read our @ChemicalScience article on [1.1.1]propellane reactivity here: And our @ACSCatalysis article on photoredox BCP synthesis here: Thanks for reading! (6/6)

A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis

Photoredox catalysis has transformed the landscape of radical-based synthetic chemistry. Additions of radicals generated through photoredox catalysis to carbon–carbon π-bonds are well-established;...

pubs.acs.org

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Alistair Sterling

@ASterlingChem

2 years

Exciting recent work from Albrecht, Peña, Gross & co () on single-molecule reaction selectivity in this week's @mhg_group journal club – discussions ranging from Bergman cyclisations, to the (un)observability of orbitals, & JT-induced charge/spin separation

Selectivity in single-molecule reactions by tip-induced redox chemistry

Different bonds are formed selectively in a molecule by atom manipulation with the voltages applied using a scanning probe tip.

www.science.org

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Alistair Sterling

@ASterlingChem

4 years

Really exciting work! Functionalisation of BCP iodides that can be easily made with previous photoredox / BEt3 methodologies from [1.1.1]propellane

Ed Anderson Group 🇺🇦

@EdAndersonGroup

4 years

Check out our latest BCP work: A way to directly couple BCP iodides with aryl Grignards. Nice work @JNugentChem , Beth and the BCP team! Synthesis of All-carbon Disubstituted Bicyclo[1.1.1]pentanes by Fe-Catalyzed Kumada CrossCoupling via @figshare

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Alistair Sterling

@ASterlingChem

1 year

Fantastic to see this paper out from @DonohoeGroup @duarte_group . I'd like to highlight the computational work from Part II student Jacky Sze – he did this work fully remotely from HK (with a 7 hour time difference!) during the pandemic. No mean feat!

Donohoe Group

@DonohoeGroup

1 year

Congratulations everyone on our latest paper in @angew_chem describing aluminium reagents for efficient hydride shifts.

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Alistair Sterling

@ASterlingChem

4 years

Really cool work with a great web app to match! Congrats @TYoungResearch , Razvan and @fjduarteg !

Duarte Group

@duarte_group

4 years

Check out Tom ( @TYoungResearch ) and Razvan's work on the automation of metallocage self-assembly and binding calculations, now on @ChemRxiv ! You can try it out yourself with our shiny new web app here: #compchem

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Alistair Sterling

@ASterlingChem

8 months

@radscientist_ My all time favourite is the Ohira-Bestmann modification of the Seyferth-Gilbert homologation because it's such a cool mechanism, with a close second of the Morita-Baylis-Hilmann reaction (added bonus that it's been at the centre of computational controversy)

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Alistair Sterling

@ASterlingChem

1 year

Great BCP perspective from @BethanyShire @EdAndersonGroup - congratulations!

Ed Anderson Group 🇺🇦

@EdAndersonGroup

1 year

@EdAndersonGroup is delighted to share our Perspective on the beautiful BCP framework in @JACS_Au . Congratulations @BethanyShire on this article! See: Conquering the Synthesis and Functionalization of Bicyclo[1.1.1]pentanes

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Alistair Sterling

@ASterlingChem

5 years

@TsybizovaA @Aromaticist @ElkinTanya @NotHF @Humulonimbus @Phil_Knutson_ @andrechemist @suzchem @anatmilo @DobrovetskyG @AMSzpilman @Boris_Maryasin @robpollice @jovana_v_milic @roiporanne @PappoDoron @rovibrational @QCstein @LivWithoutLimit @DanielCavlovic 1. I sneeze when it's sunny 2. Would love to be a musician 3. Used to own goats #3facts5scientists @MattDHannigan @kevincsumich @bojipeng @Matthew17593264 @AlyssaGilbertAU

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Alistair Sterling

@ASterlingChem

3 years

@fjduarteg Thank you Fernanda! I'm lucky to have had the chance to be a part of your group - and looking forward to another 6 months!

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Alistair Sterling

@ASterlingChem

5 years

This is a topical article #punintended

Picture It Chemistry

@PictureItChem

5 years

Sunscreen

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Alistair Sterling

@ASterlingChem

6 years

Script to generate #ORCA IRC input files (until 4.1 is released) for the use of its steepest-descent algorithm

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Alistair Sterling

@ASterlingChem

1 year

We construct a simple kinetic energy decomposition scheme that disentangles electron delocalization effects from orbital relaxations, revealing an important effect that we call 'node-induced electron confinement', which occurs when valence orbitals with a node overlap. (2/3)

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Alistair Sterling

@ASterlingChem

6 years

Great talk today from Thomas Kaiser (Emory University) on the use of machine learning in drug development - 14 to 28 years-worth of hit-to-lead development in just a year

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Alistair Sterling

@ASterlingChem

5 years

A very important preprint from the @WheelerCompChem group - don't skimp on grids! #gridgate #compchem

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Alistair Sterling

@ASterlingChem

3 years

We wrote a blog post to accompany this work, which you can read here if you're interested:

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Alistair Sterling

@ASterlingChem

5 months

@fjduarteg @UTDallasChemBio @CisnerosRes Thank you Fernanda. That's good advice, as always!

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Alistair Sterling

@ASterlingChem

5 years

Did anyone else think the setting for the Tory leadership debate looked familiar? #gunge #getyourownback

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Alistair Sterling

@ASterlingChem

1 year

The resulting theory is used to look at classic periodic trends in bond strengths, revealing a fine balance of delocalizing and localizing effects that combine to sometimes strengthen, and sometimes weaken, chemical bonds. (3/3)

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Alistair Sterling

@ASterlingChem

9 months

@KGAndrews_ @DurhamChemistry Congratulations Keith! 🍻🥳

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Alistair Sterling

@ASterlingChem

3 years

Come and work with us in Oxford! A PhD position to start in October is now open #compchem

Fernanda Duarte

@fjduarteg

3 years

We have a funded #compchem PhD position @duarte_group @OxfordChemistry to start in Oct 2022. This exciting project w/ @ASTRAZENECAUK focuses on the development of computational tools to guide reaction optimisation/catalyst design. Please RT, deadline 25/03

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Alistair Sterling

@ASterlingChem

4 years

Since then, we've been interested in the enantioselective installation of BCPs to achiral substrates. We're excited to share the results of these efforts very soon! (5/6)

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Alistair Sterling

@ASterlingChem

2 years

@TYoungResearch Looking at the problem you have, and how rare it is you get a molecule that doesn't obey your distance criterion, could you have a flag for pathological cases where you define the bonds you want manually? Either by submitting a custom bond order matrix, or a list like in NBO?

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Alistair Sterling

@ASterlingChem

3 years

There's also an unusual dependence of enantioselectivity on the photocatalyst, which could indicate that C-C bond formation is not the enantiodetermining step. We instead suggest that the enamine E/Z ratio and relative oxidation rates determine the observed selectivity. (3/4)

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Alistair Sterling

@ASterlingChem

1 year

@HarryWTMorgan1 Ctrl+c, open up excel, ctrl+v, ctrl+a, use the built-in pie chart function 🙌 Pro tip: make sure to use the default settings

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Alistair Sterling

@ASterlingChem

4 years

Alongside this work, we designed a mild photoredox reaction to generate a wide range of BCPs from [1.1.1]propellane, including biomolecules and pharmaceutical derivatives. Mechanistic studies revealed a photoredox-initiated chain process. (4/6)

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Alistair Sterling

@ASterlingChem

5 months

@CisnerosRes @UTDallasChemBio @duarte_group @EdAndersonGroup @mhg_group @UT_Dallas @UTDScience Thanks - looking forward to working with you too Andrés!

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Alistair Sterling

@ASterlingChem

4 years

@romain_costil @fjduarteg Thanks for the opportunity to work with you and @JonathanClayden on this! Excited to see the paper out!

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Alistair Sterling

@ASterlingChem

4 years

#RSCOrg #RSCPhys

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Alistair Sterling

@ASterlingChem

4 years

@GawelPrzemyslaw @HLAGroupOx @angew_chem @Yueze_Gao @cpatrickchem Great work Przemek!

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Alistair Sterling

@ASterlingChem

4 years

@raghurama123 This is brilliant!

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Alistair Sterling

@ASterlingChem

8 months

@fjduarteg @duarte_group Fantastic news Fernanda - congratulations!

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Alistair Sterling

@ASterlingChem

4 years

Using computation, we found that the electron density that should be localised in the interbridgehead C–C bond is actually partially delocalised onto the methylene bridges. This delocalisation explains the stability of [1.1.1]propellane, and its reactivity. (3/6)

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Alistair Sterling

@ASterlingChem

5 months

@filippo_romiti @UTDallasChemBio @UT_Dallas Thanks Filo! Looking forward to joining

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Alistair Sterling

@ASterlingChem

5 months

@PierMorgante @UTDallasChemBio @duarte_group @EdAndersonGroup @mhg_group @UT_Dallas @UTDScience That's very kind, thank you!

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Alistair Sterling

@ASterlingChem

5 months

@MAbbas003 @UTDallasChemBio @duarte_group @EdAndersonGroup @mhg_group @UT_Dallas @UTDScience Thank you!

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Alistair Sterling

@ASterlingChem

1 year

@HarryWTMorgan1 @patricia_poths Excellent title

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Alistair Sterling

@ASterlingChem

5 months

@Snekumari @UTDallasChemBio @duarte_group @EdAndersonGroup @mhg_group @UT_Dallas @UTDScience It was great to meet you too, thanks for your welcome!

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Alistair Sterling

@ASterlingChem

3 years

We looked at the origins of enantioselectivity, and found that substrate/organocatalyst non-covalent interactions are crucial for blocking one face of the radical. (2/4)

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Alistair Sterling

@ASterlingChem

1 year

At 5.40pm on Monday at the Chemical Bonding Theory session (Room 205, South Bldg., Moscone Center) I'll share some new results about the roles of delocalization and orbital contraction on the formation of covalent bonds (3/4)

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Alistair Sterling

@ASterlingChem

3 years

@MichelRickhaus @EdAndersonGroup @duarte_group @houk1000 Thanks Michel!

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Alistair Sterling

@ASterlingChem

5 months

@rjmchem @J_A_C_S @mhg_group @UCBerkeley @UCB_Chemistry @BerkeleyLab Thank you!

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Alistair Sterling

@ASterlingChem

5 years

@kayleight1 I help the people who help the people who help the people who cure cancer, if that counts?

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Alistair Sterling

@ASterlingChem

5 months

@kacarter2016 @UTDallasChemBio @duarte_group @EdAndersonGroup @mhg_group @UT_Dallas @UTDScience Thank you Kim!

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Alistair Sterling

@ASterlingChem

4 years

We want to design new reactions to make bicyclopentanes (BCPs), because they're useful sp3-rich structures for drug discovery (and more). We think the best way to do this is from [1.1.1]propellane. Its reactivity profile was poorly understood, so we wanted to change that. (2/6)

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Alistair Sterling

@ASterlingChem

5 months

@DasLabSMU @UTDallasChemBio @duarte_group @EdAndersonGroup @mhg_group @UT_Dallas @UTDScience Thank you!

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Alistair Sterling

@ASterlingChem

5 months

@MayankM72 @J_A_C_S @mhg_group @UCBerkeley @UCB_Chemistry @BerkeleyLab Thank you!

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Alistair Sterling

@ASterlingChem

5 months

@GevorgyanLab @UTDallasChemBio Thanks! I'm looking forward to working together

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Alistair Sterling

@ASterlingChem

3 years

@mmhaugland @SOSChem @thiemechemistry Congratulations Marius! They've made a great choice

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Alistair Sterling

@ASterlingChem

8 months

@CroixLaconsay @ListLaboratory @TantilloLab @Nature Very nice work Croix!

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Alistair Sterling

@ASterlingChem

5 years

@TrevorAHamlin Thanks! We think ∆E(int) > 0 because the cage can't distort enough to overcome repulsion between the anion and the e- rich cage at the TS. We've done the analysis along the reaction coordinate and it is consistent with this view. Open to any suggestions you might have!

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Alistair Sterling

@ASterlingChem

5 years

@MustLoveScience Orange-tinted specs made a huge difference when doing quantum yield measurements in a dark room - would have been unbearable without them

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Alistair Sterling

@ASterlingChem

9 months

If you like radical clocks, polytopal rearrangements, Hammett plots, and questions about Cu–C covalency, then maybe you'll like our paper! @UCB_Chemistry @BerkeleyLab

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