I've made a number of infographics since joining Twitter and many are buried in my timeline
I figured I'd start a thread of all the infographics I've made over the years so they are more readily available!
👇 🖼️
Can we start a drug name story thread?
I'll start
Ambien got its name from a little bit of crappy Spanish - after your night's sleep, you should have an AM that is bien
VICODIN'S NAME comes from the fact that it is 6 times stronger than codeine so, they used VI (the roman numeral for 6) + CODeINe (dropped the e's from codeine)= VICODIN
Attention📢📢 : New aneurysmal subarachnoid hemorrhage guidelines just dropped!
Lots of new updates to the last guidelines published in 2012, lets check them out below 👇
The ECMO circuit causes a number of changes to how medications distribute throughout the body - here's a quick guide to some of the most common clinically relevant considerations!
Big life announcement!
After a trial of westward expansion, I'm coming home - I am elated to announce I accepted a position as a neurosciences clinical pharmacist at Mass Gen!
I can't wait to move to Boston and start the job I've been dreaming of since pharmacy school 🧠
Did you see
@NEJM
recently released new guidelines for the use of P values in clinical trials?
I thought I'd put together a little guide to understand how they are misused/misinterpreted for PGY1s (or anyone who wants a refresher!)
Imposter syndrome is often billed as a feeling that you made it into your position because of a mistake, but my special brand of evolved imposter syndrome™ is not that I feel like I'm unqualified; it's that I feel like I am constantly underperforming despite my qualifications
We've had a few patients with mitochondrial diseases recently and I've had to refresh myself on the details of the ol powerhouses of the cell.
While each disease is unique, there is a common set of meds to avoid. I put together a 1-pager for common ones!
#NeuroCritCare
Trying to remember even the names all of the available antiepileptic drugs can be challenging, let alone their place in therapy. One way I like to think about them is by their "spectrum of activity," just like how we think about antibiotics! 🧠
#NeuroPharm
Remind me again why the hell pharmacists are the only healthcare professional (that I know of) that needs to take a separate licensing exam for state laws?
If I read one more shall, may, should, or must my head is going to explode
Warfarin is a classic, a coumARIN discovered at the Wisconsin Agricultural Research Foundation (WARF) after investigating why so many cows were hemorrhaging after eating moldy sweet clover
As a resident, I loved the rabbit holes I was sent down trying answer to a question. I post many of them here, but I can't capture nuance in 280 characters
Introducing Neu℞oWise - a place to share some deep dives and thoughts on pharmacotherapy in NCC!
I am SO excited to announce my first publication finally hit press today! Learned a lot through this process (including...patience) and I'm thrilled to share our workflow for pharmacists to evaluate renal clearance/IBW in transgender patients.
Guess I should join the party - this season I had to decide between two specialties I loved and knew I would grow so much in: crit care and ID. I ultimately landed right where I wanted. I'm so excited to announce I will be continuing on for a PGY2 in critical care
@OHSUNews
!
Does anyone else get oddly uncomfortable when you see the bottom half of someone's face for the first time after having met them wearing a mask or just me
*arrives at patient room out of breath*
I heard there were intestinal cholesterol uptake transporters that were uninhibited and I got here as fast as I could!
Free VPA levels are unpredictable in the ICU, but an equation was just validated to estimate free VPA levels in ICU patients - the Fraser equation
@CBthePHARMD
To make it more user-friendly, I made an app and am hosting it on Neurxowise, check it out!
A key point in ACLS is that in shockable rhythms, the ⚡ is key to improving outcomes
A knee-jerk reaction in a code is to give epi, but epi before shock in a shockable rhythm WORSENS outcomes
⚡once, then ⚡ again, THEN give epi
Ok maybe orgo is useless for everyday practice but how else would my team have appreciated my rounds-stopping med chem fun facts like how Onfi (clobazam) got its name because it's a ONe-FIve nitrogen substituted benzo rather than a 1,4 giving it higher GABA α-2 subunit affinity
Walked out of Mayo for the last time today; what a surreal experience
While this year was... Unorthodox, I still experienced immense personal and professional growth and had a ton of fun doing it. I can't thank my preceptors and mentors enough for their guidance! On to PGY2!
@MeganARech
@JACCPJournal
@gmjones09
@beaverspharmd
"working with difficult physician colleagues did not influence rate of burnout; however, working with difficult pharmacist colleagues increased the odds of burnout by 110%."
We are truly our own worst enemy...
Awesome, much needed article! Great work!
European Stroke Organization released an expedited recommendation for TNK: expert consensus recommends tenecteplase OVER alteplase given potential safety benefits and ease of administration!
Highlights from committee meta analysis below 👇
Fun pharmacy catch today -
Patient had rapidly rising phos but normal Cr and normal Ca and had not received any phos repletion during stay (and RN confirmed lab drawn off A line)
The culprit? The A-line had heparinized saline running which is buffered with sodium phos
While not typically considered to contribute to seizures, high-dose chronic levodopa can lead to refractory pyridoxine deficiency seizures
Levodopa needs B6 as a cofactor in its metabolism to dopamine, leading to depletion, ⬇️GABA production, and seizure
Always inspired by the grit and perseverance of providers who soldier through every duplicate order warning when they put in an entire 20-order order set twice
Every look at a vasopressor receptor affinity table and think... but why?
Some minor structural differences between agents can greatly change how pressors interact with α and β receptors.
(This doesn't work with dobutamine whose pesky (+) and (-) enantiomers act differently)
The ANNEXA-4 statistician running the 37th post-hoc adjusted model of the trial data in a desperate attempt to squeeze every p<0.05 out of the trial data set
I'm giving a talk on manuscript writing for our residents in a few weeks - the last section is "quality of life" tips for making writing easier. Some are obvious (citation software, etc), but what are some QoL things you have discovered that improve your writing experience?
Finds interesting fact in review article
Citation is another review article
Review article cites textbook
Textbook cites another textbook
Older textbook has no citation
There's nothing quite like the feeling when a seasoned MICU attending is gearing up to teach the team something on rounds but then turns to you and says "correct me if I'm wrong"
Congratulations to these
@SCCM
CPP section award/scholarship winners!👏👏👏
⭐️Distinguished Service Award - Joe Dasta
⭐️Congress Scholarship -
@SESmithPharmD
⭐️Innovations in Patient and Medication Safety - Alexa Nardone
⭐️Young Pharmacist Investigator -
@AJWPharm
#PharmICU
VFib in the field: ⚡, 5 epis, amio AND lido. More ⚡⚡& epi in resus with no luck
Esmolol 500mcg/kg bolus then infusion and they sail to ROSC and the cath lab
Probably the mix of it all but this will forever be my "one time we used esmolol" story
Ok ED is kinda cool
My favorite story of this myth in action was when vanc/cefepime was ordered for UTI - I called asking why they needed vanc & the response was to cover enterococcus
When I suggested pip/tazo monotherapy, they pushed back, d/t concern for nephrotoxicity
But they were ok with vanc
PIPERACILLIN-TAZOBACTAM IS NOT NEPHROTOXIC: exploring the arc of a myth over time
this was clearly a myth in 2016:
blog from 2022 exploring the evolution of this myth:
fresh RCT to finally settle this:
We know IV push Keppra is safe, but status-sized loading doses remain unexplored vs piggyback
I'm excited to share former PGY2 EM
@MadisonKoons1
's work on IVP LEV loads (vs IVPB):
- Faster time to admin
- No incr in ADEs
- Potential ⬇️ICU admits in SE!
Ahh precepting, a fulfilling experience of helping to develop the next generation of pharmacists made only sweeter by the requirement to fill out a 20 page, 47 item evaluation
If your patient with ESRD is bradycardic, please don't forget to check if atenolol is on their home med list
They may have been in the hospital for a few days, but their last dose of atenolol is still along for the ride
Oh, and if you see it - discontinue it
#OTILT
is the saying "piss like a race horse" refers to horses being given a dose of furosemide prior to a race to reduce the risk of exercise induced pulmonary hemorrhage and improve race performance
I'm not sure what to do with this information but there you go
Patience pays off - at long last, our final manuscript on bromocriptine for central fever has been published!
We describe 30 pts where bromocriptine was used for central fever. It was modestly effective overall, although some patients (esp SAH patients) saw a dramatic response
Thrilled to see my PGY1 research in print today! TEG fans will be excited to see we found K time and a angle were significantly associated with hemorrhage expansion in patients with severe TBI
Thanks to my team and mentors
@Dre_pharmd
@CBthePHARMD
for helping this come to life!
I'm thinking we could use a "10 false beliefs of critical care pharmacotherapy"
I'll start: resuming vanc in a decompensating patient without evidence of MRSA will not change the patient's outcome
Time is brain shown once again 🧠
Delayed initiation of therapy in first time status epilepticus is associated with increased likelihood of recurrent unprovoked seizures in a large prospective registry
Give that (full dose) benzo asap!
Guidelines times! The presenters will report the results of their systematic reviews as the recommendations are undergoing vetting
First up: Seizure prophylaxis
Do you ever have those days at work where despite all signs showing you're doing Just Fine and your team is grateful for your input but you just can't shake the feeling you're not doing well enough?
Yea me too
When I round with the stroke team and we enter the room to examine the patient, I'm no help with the neuro exam so I give myself another job - open the blinds and update the date/day of the week on the whiteboard if it hasn't already been done
No delirium on my watch ☀️
The past few weeks I saw lots of pictures of poster presentations which means I also saw lots of pictures of pie charts. Thought I'd throw together a little data viz 101 on how pie charts are usually a poorly efficient way visualize your data
I'll do a brief thread on my thoughts, mostly because much of what is reported is not new and others have shared similar thoughts
ANNEXA-I randomized mostly sICH patients w GCS >7 w/i 15 h of last DOAC to AA vs usual care. Here is the treatment algo, from the protocol:
This is a PSA to please use the Page Break function in Word so you don't have to hammer the enter key to get things to a new page and ruin my beautiful formatting thank you for coming to my TED talk
*Team trying to figure out why a patient's wound keeps getting infected*
Me: "Does he have any pets?"
Team: "I have no idea"
Patient: "Oh yea, I let my dogs lick my wounds all the time"
Pharmacists: good for more than just drugs
Can droxidopa help patients get off pressors?
As a norepi prodrug, it may have an edge over our traditional agent of choice, midodrine. In our new multicenter study, we our experience adding droxidopa in 30 persistently hypotensive patients on pressors
Excited to present my quality improvement project on shortening the duration of antibiotic prophylaxis after neurosurgical drain placement at
@VizientInc
! Poster 240A - come by!
#ASHP19
There are dozens of antibiotics out there to treat infections
But few are quite as time-tested and reliable as vancomycin
Here are 11 reasons why you might as well just go ahead and start your patient on vancomycin 👇
Honored that my first published article has made it on to the
@AJHPOfficial
Top 25 Articles of 2020! Important area of research deserving of more attention.
Buying a bag of chocolate chips: This will be great when I get the inspiration to bake
Owning a bag of chocolate chip: This is a suitable replacement for all three meals and applicable snacks
Young patient started on vanc and 2-point PK shows calculated peak of ~120 & trough of ~4 w/ T1/2 of 1.5h and Vd of ~8L. Seems wrong. Repeat levels and same result.
Change to continuous infusion of 3.5g/24h (145mg/h / Vd of 8L = Cpss of ~18 mg/L)
First level on CI? 17.4
Taught my team about CysC today - CrCl >120 mL/min but vanc >20 with 15mg/kg q12? Cystatin C tells a different story. The attending's reaction - "why don't we use this more??"
Thanks to
@erin_barreto
and co for teaching me there's more to renal function than just creatinine