1/ 🚨 NEW PAPER OUT! 🚨
Our new paper, the 1st investigating the effects of
#psychedelics
on s€xual functioning, is finally out in
@SciReports
! ❤️🔥
We found that psilocybin therapy (and naturalistic use of psychedelics) might improve sexual pleasure,
1/ Australia just became the first country in the world to officially legalise psychedelics for medical use. From July, authorised psychiatrists will be able to prescribe the drugs for PTSD and severe depression.
1/ A new study explored the effects of
#psilocybin
on human neurons, revealing for the first time how the compound found in “magic mushrooms” affects
#human
brain cells and
#neuroplasticity
. 🍄🧠
1/ I’m so excited to finally share that I will start my PhD with
@Imperial_PRG
next month. The focus of it will be on the brain correlates of the 5-MeO-DMT experience and on the intersection between psychedelics and relationships, romantic and not.
@PhDVoice
@imperialcollege
1/ The short acting psychedelic DMT might induce long term improvements in depression, according to new preliminary data. These are the first data showing that a psychedelic experience of around 30 mins might have therapeutic potential. Below a breakdown of results:
1/ How does being on
#antidepressants
(specifically SRIs) affect the
#psychedelic
experience? 💊🍄
In our new paper, Jessica Barbut and I found that those NOT on
#SRIs
had more intense experiences than those on SRIs. However, before/after changes in well-being and depression
What are people experiencing under the
#extended
state
#DMTx
at Imperial College London? 👽
Presented by
@JWSanders_
, these preliminary results show how participants try to navigate DMT alien worlds. Here are the fascinating insights gathered from participants.
#ICPR2024
1/ How does taking a NON-hallucinogenic “
#psychedelic
” compound feels like?
An interesting blog report on the compound Tabernanthalog used in
#DavidOlson
Lab came out today, suggesting it induced a feeling of an almost “supernatural patience”, without any visual effect. 🧘
1/ Extended infusions of
#DMT
for
#six
hours? 👽 😱
In a new fascinating study, researchers explored
#extending
the effects of the psychedelic DMT for six hours to enhance
#neuroplasticity
in stroke patients.
Read below
#ICPR2024
:
1/ The first study on the effects of 2C-B has just been published! 🍭
By comparing 2C-B to
#psilocybin
it was found that the two drugs induced similar subjective alterations, with 2C-B possessing less experiential depth than psilocybin but greater euphoric and bodily qualities.
🚨 MAPS just published final Phase 3 positive results of
#MDMA
therapy for
#PTSD
, with 71.2% of patients in remission after 2 months.
This allows MAPS to now seek official approval from the US Food and Drug Administration (FDA)! A small breakdown of the results:
1/ What happens in the brain during
#entities
experiences under
#DMT
? 👽
New research by
@neurodelia
suggest that these experiences engage brain systems related to social cognition and attention, as well as a more organized and less chaotic brain state than base DMT.
#ICPR2024
“Psychedelic drugs are classified as more dangerous than opiates and cocaine, and this is not morally, medically or economically appropriate” Amazing speech from
@CrispinBlunt
on rescheduling
#psilocybin
at the
#UKparliament
.
1/ Can
#psilocybin
have positive long term effects on our
#immunesystem
function? 🦠
A new study in the prestigious medical journal
@BrainBehavImm
suggest that one dose can reduce inflammatory markers in healthy subjects, correlating with wellbeing improvements.
Takeaways:
1/ I really enjoyed presenting a poster investigating the interactions between
#psychedelics
and serotonergic
#antidepressants
using prospective survey data at
#BAP2023
meeting! 🍄💊
@Imperial_PRG
Below some results (paper in submission):
Ssris are the standard treatment for depression, but usually induce emotional blunting.
@m_wall
found that escitalopram downregulated amygdala activity while psilocybin did not, reducing depression without compromising your ability to feel.
@Imperial_PRG
#psychedelic
#ICPR2022
@marcocappato
Assurdo che una sostanza naturale e NON PSICOATTIVA che abbia grandi proprietà ansiolitiche diventi illegale mentre farmaci ansiolitici con grosso potenziale di dipendenza siano prescritti a chiunque. C’è qualcosa che non va di fondo in Italia.
(1/9) “What do common antidepressants really do? Are they just placebos?” Despite being the most common drugs prescribed in psychiatry, many recent popular articles highlighted how they might be just placebos with side effects. But is this really the case? Probably not.
New prospective study from
@JHPsychedelics
shows that psilocybin use increases wellbeing, emotion regulation, and reduces neuroticism and burnout feelings in a long-term way.
This add to the body of evidence showing that psychedelics can benefit “healthy normals” 🍄
I had a long nice chat with
@RollingStoneita
on the potential of
#psychedelics
for mental health. Maybe one of the longest ever published in
#Italy
, a country where scientific progress on psychedelics is still far behind.
Feeling quite honoured! 🇮🇹🍕
“The risk of the medicalised approach to suffering is that it can dissolve collective experience, dispersing our shared causes of distress into individual dysfunctions. This prevents us to experience suffering as a community, and to act to change”. Cool thoughts over here.
1/ A new preprint suggests that people taking
#MDMA
at the time of the terror attack at the Supernova music festival in Israel might have been less affected by
#trauma
, shedding light on MDMA's role in trauma processing.
A breakdown:
1/ Can
#psychedelics
unlock an “
#InnerHealing
” intelligence in patients?
Glad to have this piece of work out led by Joe Peill, suggesting that inner healing mechanisms can have a role in psilocybin for depression. An explainer below:
Are whole
#psychedelic
mushrooms better than synthetic psilocybin? A new nature study suggests they might be superior in enhancing
#neuroplasticity
! 🍄💊
🧵1/11
1/ What happens if you discontinue SSRI/SNRIs before
#psilocybin
therapy for depression? 🍄💊
Our new paper suggests that discontinuation might reduce the antidepressant response of psilocybin. With
@DavidErritzoe
@RCarhartHarris
etc..
“Is psilocybin likely to be superior to escitalopram?” A new bayesian analysis of the NEJM data says that it’s probably the case, but might not be to a meaningful degree. While all depression scales apart QUIDS favour psilo, only HAMD-17 scale suggests a meaningful difference.
@marcocappato
Che tristezza l’Italia ultimamente. Il bello è che anche mettendole sotto il naso i molteplici studi scientifici che dimostrano come alcool e tabacco siano molto più dannosi di varie sostanze illegali probabilmente non cambierebbe comunque idea.
1/ Can
#microdosing
LSD or psilocybin cause heart issues? Interesting talk by
@KelanLT
suggests this might be the case, and more research is needed.
Why is so? Activation of 5-HT2B receptors appears to be the mechanism.
#ICPR2024
(1/5) New preliminary results show that psilocybin-assisted therapy could have potential in treating Bipolar II Disorder. Very curious to hear thoughts on this.
#Psilocybin
#psychedelics
1/ A new study comparison of
#LSD
,
#psilocybin
and
#mescaline
did not find any difference in their effects beyond duration.
Are existing scales simply not good enough to capture them or people who report differences in naturalistic settings just have different set and settings?
🧵1/ LSD-assisted therapy might reduce
#anxiety
symptoms up to 1 year after treatment, according to a new study in the esteemed psychiatry journal
@TheBJPsych
!
#LSD
#psychedelics
Considerare il
#CBD
una sostanza stupefacente non ha alcun senso dal punto di vista SCIENTIFICO, e ciò può causare diverse barriere a persone affette da
#ansia
e dolore cronico.
Sotto 5 ragioni per cui considerare il CBD stupefacente è una ca*****:
@marcocappato
Per informazione includo la tabella che presenta come l’alcool sia la droga più dannosa in circolazione (quando viene sommato il danno provocato a se stessi e ad altri), pubblicata in una delle riviste mediche più prestigiose del mondo.
1/ A new paper shows that a non-hallucinogenic LSD analogue (shown to not induce psychedelic-like effects in humans) promotes neuroplasticity in mice, potentially showing promise for the treatment of mood disorders:
(1/5) Lifetime use of psilocybin or MDMA is associated with lower odds of experiencing stress and suicidality, but only if you are white. Benefits for other racial or ethnic minorities were much lower or not present. Correlation is not causation but..
1/ Does LSD microdosing actually provide any benefit in healthy people? The latest study on the topic suggests it might improve wellbeing acutely, but NO evidence for long term improvements in mood or cognition was found.
9/ Interestingly, during
#entity
encounters, brain entropy was reduced compared to generic DMT states. This suggests a more organized and less chaotic brain state during these specific moments of experience.
1/ Clinical outcomes in psychiatry did not improve at all in the last 30 years, despite 10 of billions of pounds spent on psychiatry in the last 2 decades and increasing use of drugs. Is this really the case? And if so, why? I’d love to hear different opinions on this.
Microdosing
#psychedelics
does NOT appear to improve cognitive function (attention, memory, processing speed, etc) according to a new naturalistic study! 🤔
Effects were NOT significant either on dosing day or the day after, adding doubts to the effectiveness of
#microdosing
.
🚨 NEW SURVEY PROJECT 🚨
Are you planning to take
#psychedelics
/
#MDMA
or attend a psychedelic retreat with your
#romantic
partner and want to help psychedelic research?
Click here to know more and sign up:
Saturday I presented a poster at
#ICPR2022
on the effects of psychedelics on sexual function in healthy and depressed subjects with Bruna Giribaldi. Glad people were interested! 👩❤️💋👨
(Here some key results but being careful to interpret before the paper is out)
#psychedelic
#LSD
1/ Ieri sera ho parlato dell’uso terapeutico di sostanze psichedeliche come
#LSD
e
#psilocibina
in psichiatria con
@gloquenzi
a
@Radio1Rai
. Perchè in italia ancora non se ne parla nonostante 10 anni di ricerca accademica sempre più solida?
I just finished "Psychology of the Unconscious" by Jung. It's been a while since I immersed myself in
#psychoanalysis
, and I'm glad I returned to it.
There's a lot of wisdom in these works that applies to psychedelics, even though the vocabulary has changed over the years.
Combining
#LSD
/
#psilocybin
with a lowdose of MDMA might reduce challenging experiences whilst increasing positive ones (such as gratitude & love), according to a new study on
@SciReports
. ❤️🔥
Beyond party settings, could this be a new therapeutic tool?
Next Saturday at ICPR 2022 I will present a poster on the effects of psychedelics on sexual functioning and satisfaction, either in healthy people and depressed subjects compared to escitalopram (coming from last
@Imperial_PRG
psilodep 2 trial). 👩❤️💋👨
Massively grateful for presenting my work at
#PS2023
. This was my first big keynote talk, felt so special.
This conference felt like an historic moment in time, with such a vibrant, loving and multifaceted crowd. Really curious to see where all this will lead to.
#psychedelics
5/ A blog post came out today in which the author reported that at 150mg, Tabernanthalog induced a sense ‘supernatural patience’ , aligning with Zen teachings of ‘nowhere to go, nothing to do,’ and fostering a deep sense of equanimity.
Did you know that
#oxytocin
, popularly known as the
#love
or bond hormone can increase feelings of envy and enjoyment of others’ misfortune?
#neurochemistry
is never black or white. // Love Drugs by
@briandavidearp
NEW results from the second biggest trial ( N>100) of
#psilocybin
assisted therapy for
#depression
have just been published in
@JAMA_current
.
The study shows a sustained antidepressant response lasting at least 6 weeks as well as improvements in psychosocial functioning.
“It’s absurd we try to examine this phenomenon, scanning my brain to figure out what’s happening [..] It’s human arrogance, trying to tame all the beauty”
Funny quote at the end of an amazing talk on neuro-imaging research on psychedelics 🍄.
#ICPR2022
#Psilocybin
1/ Are
#psychedelics
a safe self-treatment option for
#mentalhealth
? As interest in psychedelic therapy grows, so too does the trend of self-treatment.
A new survey study shows that there are benefits, but risks may be higher than treatments in controlled settings.
On my way to Exeter for
@breakingcon
! Join me and Bruna Giribaldi at 10.30 on Saturday for our talk on the effects of
#psychedelics
on sexual satisfaction in both healthy and depressed people. 🍄☮️
Glad to be one of the invited speakers.
#BreakingConvention
How much psychedelic therapeutic effects are linked to placebo?
New data presented by
@RCarhartHarris
show that positive expectations before psilocybin (how much the patient thought the therapy would help) was not predictive of outcomes, suggesting an effect beyond placebo.
“Tommaso Barba, ricercatore dell'Imperial College di Londra, fa il punto sulle ricerche sull'uso terapeutico delle sostanze psichedeliche come LSD e psilocibina in psichiatria” Qui la mia chiaccherata con
@gloquenzi
a
@ZappingRadio1
.
1/ Last Saturday I had my first keynote presentation at
@UniExeCornwall
for Breaking Convention. Me and Bruna Giribaldi from
@Imperial_PRG
presented our data on the effects of
#psychedelics
on
#sexualfunctioning
in both healthy and depressed people. I’m teasing some slides here:
When will
#MDMA
therapy actually be commercialised? End of 2024 seems the time.
Latest plans from
@MAPS
plan to release data from Phase 3 in the next 3 months, and submit to the FDA by the end of 2023. FDA approval is expected by half of 2024, and first patients end of 2024.
1/ I think that one of the biggest lies of our culture is that you must be independent, fully self sufficient, that you don’t need anyone. It’s not how we are designed. Human beings are wired for interdependence, designed for meaningful connections and collective living.
Psychopathology is an acquired process, a defence mechanism resulting from progressive distress and traumatisation, which often results in entrenched cognition and behaviour”. Inspiring talk by
@RCarhartHarris
on his upcoming work on the nature of psychopathology.
@MicrodoseHQ
1/ Can psilocybin be a treatment for anorexia?
➡️ The results from the first feasibility study have been published in
@NatureMedicine
. It suggests that the treatment was safe and tolerated, and most patients reported positive effects in their life, especially at 3 months.
Venerdì 14/10 interverrò all’Università di Modena per parlare del potenziale delle sostanze psichedeliche in psichiatria al convegno "Sentieri Psichedelici: nuovi ambiti di ricerca e potenzialità per la salute" organizzato da
@ass_coscioni
,
@federicod1vita
e
@Perdukistan
.
10/ How did sexual function change post treatment?
#Psilocybin
increased sexual interest, activity, arousal, and satisfaction, while those on the
#SSRI
escitalopram reported declines. Anxiety related to sex decreased for psilocybin but increased for the SSRI.
1/Can
#psilocybin
use make people lazier and less willing to work hard? Or does it promote better work-life balance? 🧘
A new study curiously found that psilocybin use is associated with a lower number of
#overtimehours
worked, and a lower likelihood of working overtime at all.
1/ Can
#ketamine
be an effective tool to combine with
#couples
therapy? ❤️🔥
The first study investigating its effects suggests long-term
#improvements
in couple satisfaction, likely due to increased empathy and more effective communication.
I enjoyed doing a brief coverage of psychedelic research (in particular DMT research lead by the amazing
@neurodelia
) for the italian newspaper
@ilmanifesto
in occasion of the
#bicycleday
.
Italy, it’s now time to catch up on
#psychedelics
! 🍄
1/3 What’s important when dosing psychedelics?
#ICPR2022
MDMA
Body weight has a major role (if you weight more, you need more). Sex is also relevant, just if you do not account for weight. Minor effect of genetics and age. Openness (personality) also predicts good effects.
Could
#psychedelics
enhance relationship
#intimacy
? A new qualitative
#study
interviewing 6 couples taking psychedelics together suggests that they might heighten self-exposure, positive involvement, and shared understanding, potentially improving relationship quality.
1/ Rick Doblin at
#ICPR2024
on the current
#MDMA
therapy controversy “We are still optimist about the 11th of August decision, even if there are additional requirements from the FDA. I worked on it for 38 years, even if it extends to 39 or 45 years, it doesn’t matter”.
Was great attending the
@Drug_Science
annual reception at the House of Lords and hear about the huge work that has been done to bring
#cannabis
and
#psychedelics
away from politics and closer to patients. I wonder if Italy will ever move in this direction too..
“It’s my goal to have no final form. To never be defined. To never stop exploring, learning. To experience life as long as I’m alive.” - Jerico Silvers
I'm excited to speak at
#ICPR2024
in Haarlem, Netherlands, next week! My talk, titled "Psychedelics and Sexuality: From Counterculture to Modern Research," will be on Saturday, June 8th. ❤️🔥
@OPEN_fndn
Might
#psychedelics
and MDMA offer a promise to improve our romantic relationships? Is it ethical to pharmacologically influence something as profound as
#love
?
Join me in a live conversation with
@ProfDavidNutt
on the 15th of August in London for the
@Drug_Science
podcast! 🫀
Watch your thoughts, they become your words; watch your words, they become your actions; watch your actions, they become your habits; watch your habits, they become your character; watch your character, it becomes your destiny.
Lao Tzu
4/ Key finding: Psilocin, the active form of psilocybin, increases Brain-Derived Neurotrophic Factor (
#BDNF
) expression. BDNF supports neuron growth and survival, crucial for learning and memory.
9/ Psilocybin therapy led to improvements in participants' sexual lives, including enhanced sexual pleasure, satisfaction with their partner and physical appearance. Those on SSRIs for six weeks only saw improvements in their perception of their appearance, with no other positive
Was fun having a chat with
@VICENews
on the potential of psychedelics for improving romantic relationships. Looking forward to release some cool research on this soon with
@Imperial_PRG
! ❤️🔥 Thanks
@matthabusby
In 2021, David E Olson’s lab reported the creation of Tabernanthalog, aiming at improving Ibogaine’s toxicity and hallucinogenic issues. This new substance proved non-toxic and non-hallucinogenic in animal models and reversed the effects of stress.
Domani sera alle 20 sarò ospite su
@Radio1Rai
per far due chiacchiere con
@gloquenzi
sul potenziale terapeutico delle sostanze psichedeliche in psichiatria, sulle differenze con gli antidepressivi classici e su come agiscono sul nostro cervello per trattare la depressione! 🍄
Was fun having a chat with
@Josh__Hardman
and
@Psyched_Alpha
folks about being a young person in the psychedelic space and move your first steps in academia! Hope it can help juniors interested in the space! 🍄
Panel: Psychedelic Careers
The final panel of our 2022 Year in Review series sees us speak to 5 early-career individuals working in psychedelics.
They sharre their stories and offer advice to those looking to make a career 'in' psychedelics.
Man, the bravest of animals, and the one most accustomed to suffering, does not repudiate suffering; he desires it, he even seeks it out, provided he is shown a meaning for it. The meaninglessness of suffering, not pain itself, was the major curse that lay over mankind so far.
11/ These findings support the idea that psilocybin promotes
#neuroplasticity
, the brain’s ability to adapt and reorganize. This study, the first using human neurons derived from stem cells, is a significant advancement in the field.
Excited to share that I will join
@PsychedelicSci
‘23 next week as a
#speaker
! 🍄 Who will be there?
My talk will be titled “
#Psychedelics
and sexual functioning: a mixed method study in healthy and depressed subjects” and it will be on Friday 23rd at 4.15 pm.
#PS2023
2/ Quite different approach from the more relaxed one of Oregon and Colorado, but it’s an amazing news for psychiatry. What do you think? I’m still ambivalent if the best way to approach this is a flexible legalisation like Oregon, or a more conservative one.
8/ Although it still appears psychoactive, this report suggests the intriguing possibility that future compounds might be able to isolate ‘psychedelic attention’ from other aspects like ‘psychedelic thought,’ ‘psychedelic emotion,’ and ‘psychedelic perception.’
4/ We found significant improvements in sexual communication, pleasure, and satisfaction post-psychedelic use, lasting up to 6 months. People were also more satisfied of physical appearance, open to new sexual experiences and viewed sex as a more spiritual act.