Director of Breast Cancer Research Program at Sarah Cannon Research Institute | Wife | Mom to 2 Girls | Tweets are My Own
#Oncology
#BCSM
,
#Cancer
, COI at link.
Theresa & the other
#clinicaltrial
patient volunteers are the heroes of
#oncology
, these brave ๐จโ๐ฉโ๐งโ๐ฆ make every drug advance possible.
I'm lucky to be Theresa's doctor and I LOVE celebrating these milestones in
@SarahCannonDocs
clinic, just motivates us to go further faster!
A ๐งต:
For any of you that haven't read the full transcript of Todd Beamer's call from United flight 93 โ๏ธ on
#September11
.
Didn't take being a ๐ฎโโ๏ธ or ๐จโ๐ to be a hero that day. Nope. Sure didn't. There were many heroes.
I will fear no evil, for thou art with meโฆ..
Todd: (softer) God help meโฆJesus help meโฆ.(clears throat and louder)
Are you guys ready?โฆโฆ..
Letโs Rollโฆโฆโฆโฆโฆโฆโฆโฆ
@tmprowell
@Uber
@lyft
When I was in Florida last week, my Uber driver had his vaccination card laminated and taped inside AND still required masks (for both of us!).
Extra tip he got!
Want to hear a happy inspiring ๐งต from oncology clinic? A story of perseverance and grit?
I saw a young woman this month in f/u that I first met almost 7 years ago...
#ASCO22
is only 2 weeks away! Below are my Top 10 abstracts I'm looking forward to in
#bcsm
across early & metastatic settings.
I've also attached the "why" - what is intriguing me about these particular abstracts or why they are important IMO.
@SarahCannonDocs
@OncoAlert
@ShikhaJainMD
@arghavan_salles
People make families in all types of ways. Rock on.
My ๐ง๐ผ ๐ง๐ผ both know they lived in petri dishes ๐งซ frozen ๐ฅถ before mommy's tummy ๐คฐand they think it's so cool how they were made from us and how much they were wanted!
Praying for you!
@acweyand
Going to the bathroom for any reason should be a given. Periods, diarrhea, UTI...No one should have to justify themselves. Even my 8 year old is fully capable of making good decisions on when to go to the bathroom.
Todd: Helloโฆ Operatorโฆlisten to meโฆI canโt speak very loud. โ This is an emergency. Iโm a passenger on a United flight to San Francisco.. We have a situation hereโฆ.Our plane has been hijackedโฆ..can you understand me?
Lisa: (exhaling a deep breath to herself) I understandโฆ
Yes, it shocked me, to be honest. Thank you for noticing, and for speaking up. Acknowledgment is how we will eliminate this.
Everyone should be treated AND addressed equally regardless of gender, ethnicity, sexual orientation.
@fumikochino
@NarjustDumaMD
@tmprowell
@OncoAlert
To the male physician who acknowledged the esteemed panel of drs during the SERDS presentation as Dr. Turner & the โother two ladiesโ
@ErikaHamilton9
@jhaveri_komal
,an apology is in order. Misogyny has no place in this cancer space.
#ASCO22
#womeninoncology
as my wifeโฆLisaโฆ.Weโve been married for 10 years. Sheโs pregnant with our 3rd child. Tell her that I love herโฆโฆ.(choking up)..Iโll always love her..(clearing throat) We have two boys.. David, heโs 3 and Andrew, heโs 1โฆ..Tell themโฆโฆ(choking) tell them that their daddy loves
them and that he is so proud of them. (clearing throat again) Our baby is due January 12thโฆ..I saw an ultra soundโฆ..it was greatโฆ.we still donโt know if itโs a girl or a boyโฆโฆโฆLisa?
Lisa: (barely able to speak) Iโll tell them, I promise Todd.
Todd: Iโm going back to the
Listen to meโฆ.I want you to hear thisโฆ.I have talked with the othersโฆ.we have decided we would not be pawns in these hijackers suicidal plot.
Lisa: Todd, what are you going to do?
Todd: Weโve hatched a plan. Four of us are going to rush the hijacker with
โฆโฆ.Lisa, will you do something for me?
Lisa: Iโll tryโฆ.if I canโฆ.Yes.
Todd: I want you to call my wife and my kids for me and tell them whatโs happened. Promise me youโll call..
Lisa: I promise โ Iโll call.
Todd: Our home number is 201 353-1073โฆโฆ.You have the same name
you pray with me?
They pray: Our father which art in Heaven
Hallowed be thy name,
Thy kingdom come, thy will be done
on earth as it is in heaven.
Give us this day our daily bread,
It was very broken English, andโฆ Iโm telling youโฆit sounded fake!
Lisa: Ok sir, please give me your name.
Todd: My name is Todd Beamer.
Lisa: Ok Toddโฆ.my name is LisaโฆDo you know your flight number? If you canโt remember, itโs on your ticket.
Todd: Itโs United Flight 93.
@jbullockruns
So what did others on your team do about it? The intern, the co-resident, the attending?
Because in situations like this, it isn't your job to stand up for yourself, it's their job to make it clear that behavior like that isn't accepted. You deserve to be supported.
And forgive us our trespasses
As we forgive our trespassers,
And lead us not into temptation
But deliver us from evil
For thine is the kingdom, and the power, and the glory
Foreverโฆ..Amen
The Lord is my shepherd, I shall not wantโฆ
He makes me to lie down in green pasture
destroyed.
Todd: Oh God โhelp us!
Lisa: A third plane was taken over by terrorists. It crashed into the Pentagon in Washington DC. Our country is under attackโฆ.and Iโm afraid that your plane may be part of their plan.
Todd: Oh dear God.
He leads me beside the still waters
He restores my soul
He leads me in paths of righteousness
for His nameโs sake
Yea, though I walk through the valley of the shadow of death
Can the hijackers see you talking on the phone?
Todd: No
Lisa: Can you tell me how many hijackers are on the plane?
Todd: There are three that we know of.
Lisa: Can you see any weapons? What kind of weapons do they have?
Todd: Yesโฆ. they donโt have gunsโฆ.they have knives
talking to his wife just before the hijacking started.She told him that hijackers had crashed two planes into the World Trade CenterโฆโฆLisa is that true??
Lisa: Toddโฆ..I have to tell you the truthโฆ..itโs very bad. The World Trade Center is gone. Both of the towers have been
with the bomb. After we take him out, weโll break into the cockpit. A stewardess is getting some boiling water to throw on the hijackers at the controls. Weโll get themโฆ.and weโll take them out. Lisa, โฆ..will you do one last thing for me?
Lisa: YesโฆWhat is it?
Todd: Would
โ they took over the plane with knives.
Lisa: Do you meanโฆlike steak knives?
Todd: No, these are razor knivesโฆlike box cutters.
Lisa: Can you tell what country these people are from?
Todd: Noโฆ..I donโt know. They sound like theyโre from the mid-east.
Please send prayers, well wishes, luck, and pixie dust to Demi tomorrow!!!
She is receiving cells tomorrow for her bone marrow transplant. She has defied odds so far and we need that to keep happening so she can beat leukemia!
(Thread w/ permission)
Todd: Yes, ..theyโฆthey killed one passenger sitting in first class. Thereโs been lots of shouting. We donโt know if the pilots are dead or alive. A flight attendant told me that the pilot and copilot had been forced from the cockpit and may have been wounded.
Lisa: Where is the
groupโif I can get back I willโฆ
Lisa: Todd, leave this line openโฆare you still there?โฆ
Lisa: (dials the phone..) Hello, FBI, my name is Lisa Jefferson, Iโm a telephone supervisor for GTE. I need to report a terrorist hijacking of a United Airlines Flight 93โฆ.Yes Iโll hold.
Lisa: Have they said what they want?
Todd: Someone announced from the cockpit that there was a bomb on board. He said he was the captain and to stay in our seats and stay quiet.
He said that they were meeting these menโs demands and returning to the airportโฆ
So....tomorrow am is my 1st race since I was 29 and stopped running to try to have kids (long story of IVFs).
It's only a 10k and I've been running 6+ miles for a month now training for a half marathon this fall, but I don't like hills so will accept all good vibes sent. ๐ค ๐
States Capital Building.
Todd: I understandโฆhold onโฆโฆIโllโฆโฆ.Iโll be back..
Lisa: Mr. Goodwin, how much time do they have before they get to Washington?
Goodwin: Not long maโam. They changed course over Cleveland;
She makes me teary every visit. Remembering the hopelessness and trepidation *I* felt with her situation and needing chemo in a shelter, to now.
Thriving. Secure. Happy. Healthy.
Never underestimate what people can accomplish. Never think any situation is hopeless.
the FBI. We have been monitoring your flight. Your plane is on a course for Washington, DC. These terrorists sent two planes into the World Trade Center and one plane into the Pentagon. Our best guess is that they plan to fly your plane into either the White House or the United
theyโre approaching Pittsburgh now. Washington may be twenty minutes away.
Todd: (breathing a little heavier) The plane seems to be changing directions just a little. Itโs getting pretty rough up here. The plane is flying real erraticโฆ.Weโre not going to make it out of here.
Goodwin is on the line and will be talking to you as well.
Todd: The others all know that this isnโt your normal hijacking. Jeremy called his wife again on his cell phone. She told him more about the World Trade Center and all.
Goodwin: Hello Todd. This is Agent Goodwin with
destination?
Lisa: The flight left Newark New Jersey at 8 A.M. departing for San Francisco. The hijackers took over the plane shortly after takeoff, and several minutes later the plane changed course โ it is now flying east.
Goodwin: Ms. JeffersonโฆI need to
talk to someone aboard that plane. Can you get me thru to the planes phone?
Lisa: I still have that line open sir, I can patch you through on a conference callโฆhold a moโฆ..
Todd: Hello Lisa, Lisa are you there?
Lisa: Yes, Iโm here. Todd, I made a call to the FBI, Agent
Goodwin: Hello, this is Agent Goodwin.. I understand you have a hijacking situation?
Lisa: Yes sir, Iโve been talking with a passenger, a Todd Beamer, on Flight 93 who managed to get to an air phone unnoticed.
Goodwin: Where did this flight originate, and what was its
Lisa: Now Todd, can you try to tell me exactly what happened?
Todd: Two of the hijackers were sitting in first class near the cockpit. A third one was sitting near the back of the coach section. The two up. front got into the cockpit somehow; there was shouting. The third
turning aroundโฆ..Thatโs it โ we changed directions. Do you hear meโฆ.weโre flying east again.
Lisa: Ok Toddโฆ. Whatโs going on with the other passengers?
Todd: Everyone isโฆ really scared. A few passengers with cell phones have made calls to relatives. A guy, Jeremy, was
ordered us to sit on the floor in the rear of the planeโฆโฆโฆ.oh Jesus.. Help!
Lisa: Toddโฆ.are you ok? Tell me whatโs happening!
Todd: Helloโฆ..Weโre going downโฆ.I think weโre going to crashโฆโฆWait โ wait a minute. No, weโre leveling offโฆ.weโre ok. I think we may be
3rd hijacker now Todd?
Todd: Heโs near the back of the plane. They forced most of the passengers into first class. There are fourteen of us here in the back. Five are flight attendants. He hasnโt noticed that I slipped into this pantry to get the phone. The guy with the bomb
hijacker said he had a bomb. It looks like a bomb. Heโs got it tied to his waist with a red belt of some kind.
Lisa: So is the door to the cockpit open?
Todd: No, the hijackers shut it behind them.
Lisa: Has anyone been injured?
Can we say it AGAIN? Louder? ๐ฃShout it maybe? ๐
โก๏ธ When ASKED, racial groups participate in trials in similar frequency ๐ฃ ๐ก
We should discuss trials with all patients. Every one. Or at tell them why they aren't eligible so they know it was considered.
#SABCS22
@OncoAlert
Did you know that
@RedCross
is super low on ๐ฉธproducts including red cells and platelets?
Today, I donated platelets. Takes a little time, but otherwise no worse for the wear. Easy way to help your community- including those facing cancer.
@SarahCannonDocs
@OncoAlert
#bcsm
Lots of talk about "negative" abstracts in
#ASCO20
plenary. โฆ
@ASCO
โฉ scientific committee felt that this type of neg study to help settle a decade old debate was infinitely impt.
What do u think: - studies just as impt as + ones? โฆ
@OncoAlert
โฉ
Savituzumab efficacy in TROPICS02 by HER2 IHC status:
โ Benefit of saci regardless of HER2 IHC
IMO ๐ฉโโ๏ธ : I will use TDXd 1st and saci 2nd for patients eligible for both
#ESMO22
@OncoAlert
#bcsm
#SABCS22
is 4 weeks away! Excited for
#bcsm
updates including overall survival data, novel compound activity, tx sequencing info, molecular data to inform tx decision, & info about pregnancy post cancer.
Attached are the top 10 (yes, I cheated) I'm excited to see!
@oncoalert
In Alexandria at
#ASCO
headquarters planning
#ASCO24
. Quick break from discussions for an ๐ to see the cherry blossoms ๐ธ.
Beautiful scenery AND company with '23 Scientific Chair
@KimmieNgMD
, '24 Scientific Chair
@AngieDemichele
, and myself '25 making 3 years of continuity.
Can you believe? In a period of 7 years went from homeless with a stage III breast cancer and despite the horrible situation, DURING chemo pulled herself out and up.
Supported her kid, got a home, a job, her daughter is graduating, and they are THRIVING.
#DB04
#bcsm
#HER2low
Wow. For pts typically classified as having TNBC, PFS improved almost 6 months, OS improved by 10 months!
HR 0.46 and 0.48
โญ๏ธTDXd for patients with low
#HER2
expression is a big deal! โญ๏ธ
Fantastic algorithm by Dr. Mayer how to approach the treatment of early HR
#bcsm
now that we have some more agents to the stage.
#SABCS21
#bcsm
@OncoAlert
Excited to share our publication of T-DXd vs. T-DM1 in pts with brain ๐ง mets from DB-03.
โญ๏ธ PFS 15 months w/T-DXd vs. 3 months w/ T-DM1
Trastuzumab deruxtecan vs trastuzumab emtansine in brain metastases in DESTINY-Breast03 trial - ESMO Open
@kylegriffin1
@Cleavon_MD
We need to continue to impose restrictions on activities, attractions, travel, etc. for those unvaccinated. If it's a choice, then it's also the venue's choice to not allow people who could harm others.
Concerts, museums, restaurants, & travel arent rights. They are privileges.
Increased incidence in radiation โข๏ธ necrosis when delivered 7 days before to 21 days after ADC.
Symptomatic Necrosis With ADCs and Concurrent Stereotactic Radiotherapy for Brain Metastases | Targeted and Immune Cancer Therapy | JAMA Oncology
#bcsm
SURVIVAL worse when pts with ER low (1-10%) breast cancer don't get endocrine therapy.
ET omission is common in this population- 42% โผ๏ธ
Benefit here specifically appears to be among those with no pCR vs. pCR to chemotherapy
#ASCO24
#bcsm
Dr. LoRusso bringing up the super important point ๐that many places have gone away from
#IHC
in favor of
#FISH
.
Very important for us all to talk to our pathologists ๐ฌ and let them know how important HER-2 IHC 1+ and 2+ is now.
#bcsm
#ASCO22
@OncoAlert
Hot take from
#HallD1
:
PALOMA-2 was more disappointing than even expected.
FAKTION impressed me more than expected in terms of magnitude of benefit.
#ASCO22
#bcsm
@OncoAlert
I saw her today. She is over 6 years out.
She now has a government job- get this- a special program focused in educational resources for homeless youth! Has fabulous gvmt insurance and benefits.
Her daughter is graduating college. Has an Etsy business grossing over 50k/year
If one airline would come out and require vaccination to travel - I would exclusively fly my family and myself on that airline.
I think the amount of business they would gain vs. lose would be astoundingly positive.
@SouthwestAir
@Delta
@UnltedAirlines
@AmericanAir
#COVID19
United Airlines just placed the biggest aircraft order in its history and expects to create 25,000 unionized jobs by 2026 in an effort to capitalize on the astonishing rebound in passenger travel. โ๏ธ
Everything about her was inspiring- her path to her career, her palpable love for her Sun and her Moon, her transparency as her body declined. Soar in peace.
Obituary: Facing death, neuroscientist Nadia Chaudhri taught us how to live | Montreal Gazette
So all- it's official- we are excited to welcome โฆ
@VivekSubbiah
โฉ and โฆ
@IshwariaMD
to โฆ
@SarahCannonDocs
and Nashvegas! ๐ค
โฉ Ishwaria Subbiah, MD Joins SCRI as Executive Director for Cancer Care Equity and Professional Wellness
Pat Lorusso says:
"everyone says grade 1 diarrhea is nothing...until you have to live with it."
"And live with it for a long time because you are NED and maybe cured"
True that, Pat.
#ASCO21
@OncoAlert
Today the FDA approved fam-trastuzumab deruxtecan-nxki (Enhertu, Daiichi Sankyo) for adult patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen.
#HER2
Thoughts? Do articles that use the term โpreventionโ bother you? I think โrisk reductionโ is a more accurate term. We can reduce the chance of cancer, but canโt prevent it all together.
@OncoAlert
#bcsm
Shifting the Focus of Breast Cancer to Prevention
90% reproducibility among pathologists ๐ฅผ on HER-2 high
But only 60% concordance on HER-2 low-eek ๐ซฃ
Frankly with DAISY data, I'm more worried about missing lows than the overcalling of lows that are actually 0. Missing out on a tx option is a big concern.
#SABCS22
@OncoAlert
#abemaciclib
#monarchE
positive and significantly reduces cancer recurrences in the โฌ๏ธ risk adjuvant setting.๐ to the patients involved who made this possible.
Verzenioยฎ Significantly Reduced Cancer Recurrence in High Risk HR+ Early Breast Cancer
First oral
#SERD
approved for HR+ metastatic
#bcsm
w/ ESR1 mutation- welcome
#elacestrant
.
Much more work being done with this class of compounds including: 1) earlier settings, 2) combinations, 3) additional novel oral SERDs coming, 4) benefit in all comers.
@OncoAlert
Im on call this wknd rounding in 2 hospitals, thoughts:
1) For the love of everything Holy, please get vaccinated. It doesn't have to be this way. VAST majority are unvaccinated.
2) Nurses are the ๐ & soul of a hospital and the care of patients. I worry about them the most.
@jmugele
๐ Really learned this moonlighting as a fellow in rural NC. In medicine when someone asks it's b/c they don't have the resources and they need help.
Saying "yes" (when possible) is so important to help a colleague AND get their patient the treatment they deserve.
#Team
Wow - bold move! Head to head CDK4/6 trial led by
@Novartis
.
#bcsm
#CDK4and6
Novartis, determined to dethrone Pfizer, will launch bold Kisqali-Ibrance head-to-head trial in breast cancer
Ok
#OncTwitter
, are you all surprised at oncology?
On one hand I feel like most people in oncology really feel called to it and are super passionate, but is satisfaction so low because it's just so so hard? Losing patients? Having tough conversations?
#bcsm
@OncoAlert
Study w/ annual vs. less frequent mammo for surveillance after
#bcsm
. No change in
#bcsm
specific survival.
The thing that bothers me about this is : does only survival matter? What about the less tx and less morbidity when a recurrence is caught earlier vs to later?
#SABCS23
@McNeill_Tweets
Our dog has an insatiable appetite for socks. Only socks. Nothing else.
Luckily they have all come back up a day or two later and she has been fine...but this is essentially a monthly affair ๐ค๐ซฃ๐ฌ
NEWS: Capivasertib approved in combination w/ fulvestrant for
#MBC
with a PI3/AKT/PTEN alteration.
Ok
#bcsm
community, what do you think about the approval for only for those with alterations? Altered subset didn't look so different than wild-type subset to me.
#TDXd
showing a 73% response rate for patients with
#brainmets
that were either newly diagnosed or progressive post local tx.
@oncoalert
#bcsm
TUXEDO-1 Efficacy of T-DXd for Patients With HER2 Breast Cancer and Active Brain Metastases - The ASCO Post
Not all deleterious BRCA mutations are created equal ๐ซ.
Copy number variants (CNV) associated with increased risk of breast cancer in BRCA1 carriers.
#bcsm
โฆ
@OncoAlert
โฉ
#BRCAm
Definite disadvantages of
#RemoteASCO2020
:
1) my step count is 1,126...would have been at 10,000 by now walking McCormick Place
2) love the Twitter, texts, and email communication. However, can't beat in-person interactions with colleagues, patients, & pharma.
#ASCO20
@OncoAlert
I am so sorry, โฆ
@NCIDirector
โฉ, that you are having to go through this.
Amazing display of leadership not only sharing her
#bcsm
diagnosis, but also publicly showing her confidence in clinical trials.
NCI Director has cancer - The Cancer Letter
Anyone else inspired going back and revisiting the discovery of
#HER2
, the original therapeutics.... seeing how far we have come, how many drugs we have, and how much the natural history to this disease has been changed?
I am.
#ASCO21
@OncoAlert
Big fan of meetings/zooms being 25 minutes instead of 30 or 50 minutes instead of 60 to allow 5-10 minutes for breaks in-between.
Also nice to be able to go to the bathroom or get something to eat/drink!
Why isn't this the standard?
If you sit in back-to-back meetings at work, read this:
Microsoft's Human Factors Lab studied 14 participants across two days of video meetings.
โข Day 1: 4 back-to-back 30-min meetings.
โข Day 2: 4 30-min meetings with 10-minute breaks in between.
Participants wore EEG caps
On my way home โ๏ธ...quick trip for a conference ๐ฉโโ๏ธwith a half marathon ๐๐ฝโโ๏ธ tacked on today.
Have to admit, it was much harder at 42 years old compared to the last I ran when I was 29๐ฌ ๐๐ฝโโ๏ธ...but โ it's done!