Engle Lab @EngleLab Twitter profile

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Engle Lab

18 days

Aug is almost here, and the 2024 OM Bootcamp kicks off soon (Mon, Aug 12, 8 am PT) @ScrippsGradPrgm @scrippsresearch • hybrid format • open to all • 2-week short course • targeted to senior undergrads / early-stage grad students Learn more:

2024 OM Bootcamp @ Scripps Research: Registration Form

docs.google.com

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Engle Lab

@EngleLab

5 years

Ni(0) for the masses! Paper now online: @angew_chem . DM your shipping address for a free sample of this precatalyst.

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Engle Lab

@EngleLab

1 year

The 2023 @ScrippsGradPrgm Organometallics Course is live. All course materials available on the web: All lectures on @YouTube :

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Engle Lab

@EngleLab

3 years

Meet the new bench-stable Ni(0) toolkit.

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Engle Lab

@EngleLab

3 years

7-coordinate, it's the new 6-coordinate. W(0) catalysis, unleashed for migratory alkene carbonylation. Led by @W0TangClan together w/ @pengliu_group . Today in @ChemRxiv : .

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Engle Lab

@EngleLab

4 years

How much NaOMe is actually in that nice-looking bottle of solid 'NaOMe' on your bench? 🤔🧐 Hint: maybe not much. Read the details in our most recent @ChemRxiv pre-print w/ #BMSChemistry here: . #RealTimeChem

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Engle Lab

@EngleLab

2 years

Huge congrats to Jin-Quan @YulabJin @scrippsresearch on his ACS Somorjai Award at #ACSSpring2022 ! Glad that we requested seatbelts in the conference room!

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Engle Lab

@EngleLab

2 years

Lucky 7⃣...coordinate! The final version of our alkene isomerization/carbonylation reaction via W(0)/W(II) catalysis is online @NatureChemistry . Led by @W0TangClan @ziyangnickqin in collaboration w/ @pengliu_group .

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Engle Lab

@EngleLab

2 years

One of the strangest reactions we've ever worked on is described today in @ChemRxiv , a redox-paired alkene addition process in which two useful products are produced within the same cycle. @NiHuiqi w/ @houk1000 @pengliu_group

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Engle Lab

@EngleLab

4 years

The team. The team. The team. 🙏🏻

Scripps Research

@scrippsresearch

4 years

Congratulations to Scripps Research's Prof. Keary Engle, who has received this year’s Catalysts Young Investigator Award. Keary is recognized for his accomplishments in #organometallic #chemistry , organic synthesis and #catalysis @MDPIOpenAccess @EngleLab

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Engle Lab

@EngleLab

2 years

What a great day to be @scrippsresearch (and to be up late writing a grant 😂). Barry becomes only the 2nd person in history to win the chemistry Nobel twice. Congrats to all laureates!

The Nobel Prize

@NobelPrize

2 years

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

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Engle Lab

@EngleLab

5 months

Pd(0) w/o the fuss... @HarryHe88239850 , Wenzhuo, & #BMSChemistry

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Engle Lab

@EngleLab

9 months

Delighted to see the final version of this collaborative study out in @angew_chem , describing a robust & scalable e-chem ⚡️ method to Ni(0) w/ #BMSChemistry @BaranLabReads @Julien07 . Thx to our fearless leader @CamZRub !

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Engle Lab

@EngleLab

2 years

What showed up under the tree last night? 👀🎁🎄 @angew_chem :

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Engle Lab

@EngleLab

3 years

W(0)/W(II) redox catalysis for alkene isomerization/hydroboration, now online in @J_A_C_S . Fun transatlantic collaboration w/ @MartinLab_ICIQ led by @W0TangClan @TitoBraulio . PS - Don't mind our subliminal messaging: W(0)/W(II)... [WOW]^2 🤩🤩

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Engle Lab

@EngleLab

2 years

That’s amore… 💕 Our brand new @MBRAUNsolutions glovebox is online in time for the new crop of G1 students.

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Engle Lab

@EngleLab

4 years

The culmination of a long journey & the start of another. Our 1st report on alkene 1,2-difunctionalization via a transient directing group. 3 rxn components 2 stereocenters: C-F and C-C 1 resilient team led by @liu_zhonglin & Luke 🧢s off! @ChemRxiv

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Engle Lab

@EngleLab

8 months

A year later, we've learned a lesson learned by many others: mechanistic work w/ Ni is hard! 🛠️ Nevertheless, we've made some progress and now share an updated @ChemRxiv pre-print shedding🔦 on how this stereodivergent isomerization works. @Julien07

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Engle Lab

@EngleLab

4 years

4+ years in the making: We’re excited to describe the first use of a chiral transient directing group in Heck-type alkene additions #JustAccepted @angew_chem . Nice work by Luke and the project team, and great as always collaborating with @pengliu_group .

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Engle Lab

@EngleLab

2 years

After >3 years of effort, very excited to share a solution to an incredibly hard selectivity control problem, stereoinduction in intermolecular arylnickel migratory insertion. @omar__apolinar @TaehoKang6 @pengliu_group @stevewiz06 #BMSChemistry @ChemRxiv

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Engle Lab

@EngleLab

2 years

The 2nd is by a massive team effort led by @omar__apolinar @TaehoKang6 & @0iTurki w/ #BMSChemistry @pengliu_group , describing the 1st enantioselective 3-component diarylation of unactivated alkenes under Ni catalysis, appearing in @J_A_C_S :

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Engle Lab

@EngleLab

3 years

During the past year, the G4 students teamed up to write a 📖 chapter on π-bond difunctionalization for Comprehensive Organometallic Chemistry IV, online this week. Thanks to our fearless editor @ianatonks ! @ELSchemistry

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Engle Lab

@EngleLab

2 years

Tungsten is known for its use in hard material, but here it offers a soft touch. Kinetic olefin transposition without over isomerization. @ChemRxiv Brought to you by Team W: @W0TangClan @CamZRub @TitoBraulio

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Engle Lab

@EngleLab

3 years

W(0) adds its own unique twist to classical catalytic alkene hydroboration. Thrilled to collaborated with chain-parkour masters @MartinLab_ICIQ . Props to project leads @W0TangClan & @TitoBraulio . #TeamTungsten @ChemRxiv pre-print:

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Engle Lab

@EngleLab

3 years

Delighted to share the final version our asymmetric Pd-catalyzed alkene 1,2-arylfluorination w/ transient directing group #JustAccepted @J_A_C_S . Key step on a long TDG quest! Bravo @liu_zhonglin & team.

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Engle Lab

@EngleLab

3 years

Slightly belated but all recordings/materials from last quarter's virtual @ScrippsGradPrgm 2021 Organometallics Grad Course are now updated and freely available. Experience it yourself, connection drops included!😎 Videos: Website:

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Engle Lab

@EngleLab

3 years

Second, if you're looking for ~20 years of metal-catalyzed directed C(sp3)-H activation in one stop, @Binzju @AndrewMRomine & @CamZRub have you covered in this colossal @ACSChemRev : Great pandemic collab w/ our friends in the @bfshi lab!

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Engle Lab

@EngleLab

3 years

The final version of our #AmericasFinestCity collaboration @SDSU @UCSDChemBiochem @scrippsresearch is now #JustAccepted @angew_chem . Check out what Cu(CAAC) catalysts can do in alkyne protoborations and -silylations.

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Engle Lab

@EngleLab

2 years

The final version of our free-amine-directed Ni-catalyzed alkene carboamination paper is now online @ACSCatalysis . Great stuff by @TaehoKang6 @jmanu3 @ZiqiLi0513 & #BMSChemistry !

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Engle Lab

@EngleLab

2 years

A new mechanistic take on alkene 1,2-carbosulfenylation that proceeds w/ syn-stereoselectivity. Check out the final version of #TeamNickel 's study in @J_A_C_S this week, led by @ZiqiLi0513 .

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Engle Lab

@EngleLab

10 months

1st of a 2-part story (part 2 slated for next week!) showing how the hemilabile and redox-active properties of quinone ligands unlock 🔑 unprecedented scope in Ni-cat alkene additions: @chemrxiv @ZiqiLi0513 @0iTurki @ChicagOChemO @pengliu_group

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Engle Lab

@EngleLab

1 year

A new take on cyclopropanation by @NiHuiqi . An unusual collaboration that brings together chemists working on catalysis, high-energy materials ( @Davin_lab ), and medicines ( #PfizerChemistry ). @ChemRxiv pre-print:

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Engle Lab

@EngleLab

2 years

I like my C-H bonds broken, not stirred.

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Engle Lab

@EngleLab

4 years

Starting Mon (Aug 3), OM Bootcamp @scrippsresearch is going virtual! This year we are opening it up to undergrads (esp those at PUIs!) who may have missed out on summer research. DM for details if you’d like to take part.

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Engle Lab

@EngleLab

3 years

Start off your morning w/ a shot of alcohol. OH-directed alkene carboamination enabled by tailored N-electrophiles from @TaehoKang6 @Nana_Kem22 & #BMSChemistry in @ChemRxiv . Cheers! 🍻 #itsfiveoclocksomewhere

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Engle Lab

@EngleLab

3 years

2021 OM Bootcamp @scrippsresearch kicks off next week Mon (Aug 9) in virtual/hybrid format, open to all. We are hoping to beat last year's undergrad turnout (esp those at PUIs)! Register here: ✅

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Engle Lab

@EngleLab

4 years

It's taken a few years of tinkering, but #TeamNickel & @pengliu_group are pleased to report the next chapter in regiodivergent alkene functionalization today in @ChemRxiv . New Pyrox ligand overcomes innate reactivity prefs. @ZiqiLi0513 @bamtran24 @gytyw

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Engle Lab

@EngleLab

3 years

Teaching nitroalkanes to play nice with unactivated alkenes: @ChemRxiv @ASimlandy

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Engle Lab

@EngleLab

4 years

#TeamNickel is already at it again in 2021! Together w/ #BMSChemistry colleagues, Nana, Van, and Omar describe Ni(COD)(DMFU), an all-in-one diarylation precatalyst - part of the upcoming #Synlett @thiemechemistry Ni catalysis cluster.

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Engle Lab

@EngleLab

3 years

What can we say? We 🧡🖤🧡 making heterocycles. (Carbocycles aren't bad either.) Happy to share the latest results from our collaboration w/ @pfizer led by @NiHuiqi on the Pd(II)/Pd(IV) anti-annulation of alkenes. @ChemRxiv

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Engle Lab

@EngleLab

3 years

Pleased to share the final version of our 3-component alkenyl alcohol carboamination paper, now in @J_A_C_S by @TaehoKang6 @Nana_Kem22 #BMSChemistry :

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Engle Lab

@EngleLab

10 months

In our lab's newest @ChemRxiv pre-print @sunjuntao1 & team craft C–N chiral axes through atroposelective C(heteroaryl)-H activation. Unique products that react fast & selectively in [4+2]s.

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Engle Lab

@EngleLab

5 months

Synthesize Pd(COD)(DQ) together with the master (Wenji @HarryHe88239850 ) and the apprentice (Keary). DM your shipping info for a free sample of the catalyst made by Keary himself. Thanks to @avrlisboa for awesome filming and editing!

Synthesize Pd(COD)(DQ) with Keary and Wenji

Read the pre-print on Pd(COD)(DQ) here: https://chemrxiv.org/engage/chemrxiv/article-details/65e8f798e9ebbb4db918a09fVideo demonstrators: Prof. Keary Engle a...

www.youtube.com

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Engle Lab

@EngleLab

5 months

An academic, a process chemist, and a catalyst manufacturer walk into a pre-print... Take the plunge w/ us into the non-PGM catalyst pool!

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Engle Lab

@EngleLab

2 years

Our collaboration on selective C(alkenyl)–H activation mediated by a transient directing group, together w/ @pengliu_group , is online in final form @angew_chem : Great team effort by @MYNoblemetal @sunjuntao1 @tugcegerbay @NiHuiqi @TitoBraulio !

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Engle Lab

@EngleLab

2 years

Reviewer 3

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Engle Lab

@EngleLab

3 years

A full account of our work on Ni(0)-cat directed Markovnikov hydroarylation and -alkenylation with RB(OH)2 is online today @ChemRxiv : 3 new protocols, >70 examples, and detailed mechanistic studies by #TeamNickel @ZiqiLi0513 @omar__apolinar and Ruohan.

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Engle Lab

@EngleLab

3 years

Move over @Padres , SD's got 🔥new team on the block @SDSU @UCSDChemBiochem @scrippsresearch . CAAC ligands 💪 in Cu-boryl alkyne additions () @ChemRxiv . Game day roster ⚾️: @gytyw @YazdaniSimaChem @JunorGlen @Rodolphe_Jazzar Grotjahn & Bertrand labs.

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Engle Lab

@EngleLab

5 years

After years of failures, frustration, and false starts... We are excited to share: chiral transient directing groups in Pd-cat alkene functionalization. Brilliant stuff by Luke and team @bamtran24 @tugcegerbay @pengliu_group . The force is strong w/ this one! #RealTimeChem

ChemRxiv

@ChemRxiv

5 years

A Transient Directing Group Strategy Enables Enantioselective Reductive Heck Hydroarylation of Alkenes by Keary Engle ( @EngleLab ) & co-workers

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Engle Lab

@EngleLab

7 months

Now out in Acc Chem Res, @CamZRub @HarryHe88239850 , & @stevewiz06 chart our journey together w/ #BMSChemistry towards practical Ni(0) catalysts.

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Engle Lab

@EngleLab

6 years

Breaking bonds, taking names 😎Congrats to Van, John, and Kin on their Nat. Chem. paper describing a beta-X elimination approach to covalent bond activation.

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Engle Lab

@EngleLab

9 months

We are thankful for EDD ligands 🙏🏻 Coming soon…

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Engle Lab

@EngleLab

2 years

New additions to the synthetic 🧰 enabled by co-catalytic transient directing groups (TDGs). Enantioselective hydroalkenylation / hydroalkynylation & non-aromatic alkenyl aldehydes. Led by @ASimlandy . @ChemRxiv preprint:

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Engle Lab

@EngleLab

2 years

Still partying w/ Barry two weeks later @scrippsresearch @NobelPrize #clickchemistry 🎉🎈🎊

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Engle Lab

@EngleLab

3 years

Hey @ardemp this parking spot is open. @NobelPrize @scrippsresearch

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Engle Lab

@EngleLab

5 years

By popular demand, we are happy to offer video recordings of all lectures for Organometallics 2019 @scrippsresearch @ScrippsGradPrgm via @YouTube . Tune in, and let us know how we can make your remote learning experience as valuable as possible.

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Engle Lab

@EngleLab

9 months

Ni-quinone 📖 Part 2 is online @J_A_C_S . @Yeongyu_Hwang designed a quinone ligand to enable 1,2-carboamidation via nitrenoid transfer. Using DFT, he traced the origin of enhanced reactivity to hemilability & ⏫ electrophilicity during migratory insertion.

Ligand-Enabled Carboamidation of Unactivated Alkenes through Enhanced Organonickel Electrophilicity

Catalytic carboamination of alkenes is a powerful synthetic tool to access valuable amine scaffolds from abundant and readily available alkenes. Although a number of synthetic approaches have been...

pubs.acs.org

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Engle Lab

@EngleLab

5 years

Sometimes dreams (and dream rxns) come true! One of our dreams since 2015 has been to use simple carboxylates to direct alkene difunctionalization. @JD_Chimico , Taeho, and #TeamNickel brought the dream to life. Another fun collaboration with @stevewiz06 and #BMSChemistry .

ChemRxiv

@ChemRxiv

5 years

Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks by Keary Engle ( @EngleLab ) & co-workers

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Engle Lab

@EngleLab

1 year

In the lab's latest review, @TaehoKang6 & @omar__apolinar dive into the state of play in asymmetric Ni- and Pd-catalyzed olefin dicarbofunctionalization. Thanks to the team at Synthesis @thiemechemistry for the invitation!

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Engle Lab

@EngleLab

7 months

#4 After a technical delay at the end of 2023, we're finally ready to finish the countdown and share our lab's recent Ni review. The penultimate discovery to highlight comes from Knochel, who observed accelerated C(sp3)-C(sp3) coupling w/ an embedded EDO.

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Engle Lab

@EngleLab

3 years

Free the amines! No PG, no problem for #TeamNickel in their most recent @ChemRxiv pre-print. Leaving group tuning 🔧 of the amine electrophile is the 🔑! @TaehoKang6 @jmanu3 @ZiqiLi0513 #BMSChemistry

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Engle Lab

@EngleLab

2 years

Fluorine meets its match 💪 in a sterically tuned directing auxiliary that can squeeze out pesky C(sp3)-F bonds from the metal center. A fun new @ChemRxiv pre-print brought to you by @liu_zhonglin #BMSChemistry & team:

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Engle Lab

@EngleLab

5 years

Excited to offer samples of a new nickel(0) precatalyst from our collaboration with #BMSChemistry as part of today’s talk @StanfordUChem . Stop by at 4:30 pm to learn more. Air/water-stable ✅ Luggage-stable ✅ Pub coming soon! #TeamNickel @BurnsChemistry @du_bois_lab @YanXiaLab

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Engle Lab

@EngleLab

2 years

Our latest installment in alkene carbosulfenylation now tolerates alkylzinc nucleophiles, allowing for simultaneous C(sp3)-C(sp3) and C(sp3)-S bond formation @ChemicalScience @ZiqiLi0513 :

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Engle Lab

@EngleLab

5 years

Last year we celebrated Keary’s birthday 🎉 with the release of three chemrxiv preprints over three days 😎! This year we’re celebrating a month late due to the arrival of the newest and smolest Engle- baby Ollie 👶!

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Engle Lab

@EngleLab

4 years

Very grateful to @Amgen and excited share this recognition with the other 2020 awardees @veeslerlab @AlisonNarayanUM @jphilippejulien and Sergey Pronin.

Scripps Research

@scrippsresearch

4 years

“We are always searching for more efficient ways to discover compounds that improve human health.” Congratulations to organic #chemistry Prof. Keary Engle, who has received the Young Investigator Award from @Amgen @EngleLab #drugdiscovery

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Engle Lab

@EngleLab

2 years

We congratulate our super 🌟🤩🌟 postdoc @SkylerMendoza2 for being awarded an @NSF #MPSAscend Postdoc Fellowship @scrippsresearch . Skyler is a @CaltechCCE @sarah_reisman lab alum who is applying his synthetic chops in organometallic catalysis. Bravo!

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Engle Lab

@EngleLab

9 months

#1 As we count down⌛️ to publication of our forthcoming nickel(0) review, we highlight milestones from other labs that paved 🛣️ the way. First up: the original synthesis of Ni(CO)4 (caution: volatile and toxic).

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Engle Lab

@EngleLab

10 months

5⃣-membered azaheterocycles as directing groups for olefin diarylation. #teamnickel strikes again! @yilincao_chem @ZiqiLi0513 Celebrating @morandilab 's 2023 TYIA @ELSchemistry . Congrats Bill & team!

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Engle Lab

@EngleLab

3 years

A classical rxn with a lot left to teach us. Check out the #JustAccepted version of our mechanistic deep dive into catalytic E/Z isomerization of alkenes w/ Pd(II) led by @MatsuuraRei together w/ @DonnaBlackmond in @ACSCatalysis , formerly @ChemRxiv .

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Engle Lab

@EngleLab

3 years

CAAC ligand not afraid to put boron and carbon in their place. The latest installment of our all-SD tri-institutional collaboration on (CAAC)Cu catalysis appears today: @ChemRxiv @SDSU @UCSDChemBiochem @scrippsresearch

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Engle Lab

@EngleLab

4 years

#Thanksgiving appetizer served by #TeamNickel and #BMSChemistry 🍽🍗😋 — @omar__apolinar & team report on the unique ability of sulfonamides to direct challenging alkene 1,2-diarylation #JustAccepted @ACSCatalysis :

Sulfonamide Directivity Enables Ni-Catalyzed 1,2-Diarylation of Diverse Alkenyl Amines

1,2-Diarylation of alkenyl sulfonamides with aryl iodides and aryl boronic esters under nickel catalysis is reported. The developed method tolerates coupling partners with disparate electronic...

pubs.acs.org

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Engle Lab

@EngleLab

2 years

Engle lab students were rolling deep at #ACSSpring2022 . @ZiqiLi0513 presented not 1 but 3 posters @NiHuiqi represented #teampalladium while Yilin and Taeho showed off their work with #teamnickel . Alena presented a talk as part of the cross coupling symposium. Great work everyone!

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Engle Lab

@EngleLab

8 months

Best of luck in the adventure ahead, Amit! We miss you already @scrippsresearch .

Amit Kumar Simlandy

@ASimlandy

8 months

Thrilled to start my independent career as Assistant Professor in the department of Chemical sciences at @IISER_BERHAMPUR . Really grateful to @LabMukherjee @KBrownLab @EngleLab for the training and tremendous support during this journey.

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Engle Lab

@EngleLab

4 years

Simple conditions ➡️ Strange selectivity. Alena and John’s work on α-selective hydroarylation of Michael acceptors with #BMSChemistry is #JustAccepted @J_A_C_S . Way to go team!

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Engle Lab

@EngleLab

2 years

The final version of our @ASimlandy 's olefin/nitroalkane coupling paper is now online @ACSCatalysis . Strikingly simple combination of PdI2, HFIP, and Na2CO3 enables this previously elusive addition w/ mechanistic details from @0iTurki @pengliu_group :

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Engle Lab

@EngleLab

4 years

Kicking the week off w/ an alkene ➡️ heterocycle bonanza in @ChemRxiv . A Larock-inspired alkene (hetero)annulation w/ @pfizer and @pengliu_group .

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Engle Lab

@EngleLab

3 years

*Ringing* in 2022 🍾🔔🎉 w/ the final version of collaborative alkene annulation paper w/ our neighbors @pfizer , now online in @angew_chem : . Well done @NiHuiqi & team!

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Engle Lab

@EngleLab

9 months

#2 Seminal WW2-era contribution from Kharasch @UChiChemistry documenting C(sp2)-C(sp2) cross-coupling catalyzed by nickel. 🤩

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Engle Lab

@EngleLab

9 months

#3 From the MPI-Kofo, the heart of the organonickel revolution, comes Wilke's 1960 synthesis of Ni(COD)2 and Ni(CDT). At <500 words, every sentence packs a punch.

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Engle Lab

@EngleLab

6 years

🎂🍰🎊🎉 The Engle lab turns 3 today! Thanks to all coworkers for a great year of chemistry, and here’s to many more to come! @scrippsresearch

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Engle Lab

@EngleLab

2 years

Translating catalytic three-component difunctionalizations from alkenes to alkynes has proven harder than it looks. Now together w/ the @bfshi and Lan labs, @MYNoblemetal & @sunjuntao1 blaze a path to tetrasubstituted olefins via oxyhalogenation. @ChemRxiv

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Engle Lab

@EngleLab

4 years

Sulfonamides to the rescue! In a pre-print @ChemRxiv #TeamNickel describes how sulfonylation can enhance directing ability & enable N-functionalization of alkenyl amines. @omar__apolinar @bamtran24 @JD_Chimico #BMSChemistry

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Engle Lab

@EngleLab

5 years

Very honored to be included in this super talented cohort of 2019 #SloanFellows . Grateful to work with an awesome group of students, postdocs, and colleagues @scrippsresearch - a great team makes great research possible!

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Engle Lab

@EngleLab

10 months

The people have spoken 🗳️!Our lab’s pick for paper of the month 🏆, as presented by Wenzhuo, is the collab study on enantioselective Ni-cat couplings of unactivated alkenes from the Koh & Shi labs @NatureCatalysis . @MJKoh87

Enantioselective C–C cross-coupling of unactivated alkenes

Nature Catalysis - Enantioselective C–C cross-coupling of unactivated alkenes is challenging. Now, nickel catalysts bearing bulky C2-symmetric chiral N-heterocyclic carbene ligands enable...

www.nature.com

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Engle Lab

@EngleLab

4 years

Keepin’ 😎 while making 🟩s. In our latest pre-print w/ @pengliu_group and @pfizer we show how pi-stacking and other non-covalent interactions enable Cu-cat hydroboration of BCBs . Props to ⭐️ project leads @TaehoKang6 and @tugcegerbay !

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Engle Lab

@EngleLab

2 years

Very happy😀 to share the final versions of 2 papers today, both a long time in the making. The 1st from @liu_zhonglin & team w/ #BMSChemistry describes a selective 1,2-carbofluorination of unactivated alkenes under Pd catalysis @angew_chem :

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Engle Lab

@EngleLab

3 years

What’ve you got against fumarates after that they’ve done for you @JD_Chimico ?? @J_A_C_S #proudofalumni

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Engle Lab

@EngleLab

1 year

The final version of @ASimlandy 's study is now online in @angew_chem : . New since the pre-print: @0iTurki 's in-depth DFT study of the special feature of tert-leucine that make it such an effective TDG across different migrating groups ( @pengliu_group ).

Engle Lab

@EngleLab

2 years

New additions to the synthetic 🧰 enabled by co-catalytic transient directing groups (TDGs). Enantioselective hydroalkenylation / hydroalkynylation & non-aromatic alkenyl aldehydes. Led by @ASimlandy . @ChemRxiv preprint:

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Engle Lab

@EngleLab

4 years

Simple conditions, strange selectivity. Our newest alpha-selective hydroarylation work is online @ChemRxiv . Nice method + mechanism story from Alena, John, and #BMSChemistry .

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Engle Lab

@EngleLab

4 years

For anyone who did not get a sample of Ni(COD)(DQ) earlier this year or needs another batch, it is now available from @MilliporeSigma

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Engle Lab

@EngleLab

5 years

The first paper from #TeamNickel in 2020 is in press at @angew_chem ! Allyl electrophiles in conjunctive cross coupling with alkenes... What could possibly go wrong? Learn more: @bamtran24 @JD_Chimico @pengliu_group

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Engle Lab

@EngleLab

4 years

When Pd throws you a surprise party. @AndrewMRomine @ChemRxiv

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Engle Lab

@EngleLab

3 years

“The science belongs to you, not to me.” -Coach Hans Renata @hanzyduzit Stunning science by our treasured friend and colleague during his promotion talk @scrippsresearch . 🥅⚽️💨🏃

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Engle Lab

@EngleLab

3 years

Get your alkyne puns ready. This terminal/internal alkyne cross-coupling brought to you by our newest PhD @MYNoblemetal together w/ @Boehringer is now #JustAccepted @J_A_C_S .

Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes

Selective carbon–carbon (C–C) bond formation in chemical synthesis generally requires prefunctionalized building blocks. However, the requisite prefunctionalization steps undermine the overall...

pubs.acs.org

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Engle Lab

@EngleLab

4 years

Directed alkene hydrofunctionalization: - liked it ✅ - put a 💍 on it ✅ Newest paper w/ @pengliu_group is online @ChemRxiv .

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Engle Lab

@EngleLab

2 years

Delighted to celebrate our amazing grads👨‍🎓 @AndrewMRomine & @W0TangClan @ScrippsGradPrgm .

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Engle Lab

@EngleLab

3 years

Pushing the limits of carbonyl directivity in Ni-cat alkene diarylation: Ketones ✅ @RKlmns @omar__apolinar and the rest of #TeamNickel w/ @stevewiz06 #BMSChemistry . @ChemRxiv

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Engle Lab

@EngleLab

2 years

Elusive post-beta-alkyl elimination organopalladium complexes containing signature Pd(alkyl)(olefin) motif characterized by X-ray crystallography, w/ DFT studies by @Yue__Fu @pengliu_group . Unique @ChemRxiv pre-print from @TaehoKang6 & team:

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Engle Lab

@EngleLab

2 years

How to convince an intermediate to take the road less traveled? In our latest @ChemRxiv pre-print in collab w/ @pengliu_group , @MYNoblemetal @sunjuntao1 @tugcegerbay & team explore C(alkenyl)–H activation with a transient directing group.

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Engle Lab

@EngleLab

2 months

Tetrasubstituted olefins are their own special monsters as substrates in catalysis. Our former undergrad Hou-Xiang and his team from the Hong and Li groups tackled enantioselective hydroboration with impressive results.

Rhodium-Catalyzed Highly Enantioselective Hydroboration of Acyclic Tetrasubstituted Alkenes...

Although progress has been made in enantioselective hydroboration of di- and trisubstituted alkenes over the past decades, enantioselective hydroboration of tetrasubstituted alkenes with high...

pubs.acs.org

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