Congratulations to Zhijian โJamesโ Chen, 2024
#LaskerAward
winner! โ โfor the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.โ
#Lasker2024
#LaskerLaureate
Congratulations Dieter Oesterhelt, Peter Hegemann and Karl Deisseroth, 2021
#LaskerAward
winners!โโfor the discovery of light-sensitive proteins that can activate or silence individual neurons and for their use in
#optogenetics
โa revolutionary neuroscience techniqueโ
#Lasker2021
The 2019 Albert Lasker Basic Medical Research Award honors Max D. Cooper and Jacques Miller for their discovery of the two distinct classes of lymphocytes, B and T cellsโthe organizing principle of the adaptive immune system.
C. David Allis and Michael Grunstein won the 2018 Basic
#LaskerAward
for discovering how histone modifications influence gene expression.
@RockefellerUniv
@UCLA
In just 5 days, we reveal the scientific breakthroughs recognized this year.
#Lasker2024
โIโve always felt that you had to be better overall than the men. And thatโs true of all women, I think,โ said 2018
#LaskerLaureate
Joan Steitz from
@Yale
. โThatโs not fair; and thatโs where we need to be fighting.โ
@SteitzLab
Today, we announced that Joan Argetsinger Steitz
@SteitzLab
of
@Yale
won the 2018 Lasker~Koshland Special Achievement Award in Medical Science for her pioneering work in RNA biology and excellent mentorship of young scientists. Congratulations!
The 2024
#LaskerAward
winners are:
Basic: Zhijian โJamesโ Chen
Clinical: Joel Habener, Lotte Bjerre Knudsen, Svetlana Mojsov
Public Service: Quarraisha Abdool Karim and Salim Abdool Karim
Learn about their scientific breakthroughs in these animated videos:
Congratulations, Freddy E. Escorcia, 2021
@NIH
#Lasker
Clinical Research Scholar! Freddy is dedicated to improving the diagnosis and treatment for patients with gastrointestinal and hepatobiliary cancers.
@freddyeescorcia
Happy birthday, C. David Allis! He received a
#LaskerAward
in 2018 for discoveries elucidating how gene expression is influenced by chemical modification of
#histones
โthe proteins that package DNA within chromosomes.
@RockefellerUniv
Happy birthday to Solomon H. Snyder! He won a
#LaskerAward
for identifying opioid receptors and developing techniques to determine their precise localization.
@JohnsHopkins
Congratulations to this yearโs
#LaskerAward
winners!
Basic: Demis Hassabis and John Jumper
Clinical: James G. Fujimoto, David Huang, and Eric A. Swanson
Special Achievement: Piet Borst
Read about their Award-winning work:
#Lasker2023
#LaskerLaureate
Congratulations to C. David Allis of
@RockefellerUniv
and Michael Grunstein of
@UCLA
who won the 2018 Albert Lasker Basic Medical Research Award for discovering how histone modifications influence gene expression.
A diet high in fructose (but not glucose) can damage mitochondrial function in the liver, making it more difficult to metabolize fat, according to a new study in
@Cell_Metabolism
.
@JoslinDiabetes
Tweet: Looking for something to watch? The documentary Human Nature โ the story of
#CRISPR
โ is now available for streaming on iTunes, Vimeo, Amazon, and Google Play:
#CRISPR
is a scientific revolution that is reshaping basic science and biomedical research. A new documentary, Human Nature, tells the story of its discovery. To find out where and when the film is playing, check out:
@wondercollab
@DanRather
#LaskerLaureate
Katalin Karikรณ talks about how accessing scientific information has changed and how researchers are a bit like a fictional character she loves: Lt. Columbo.
#AskAScientist
@kkariko
A new study finds that in male
#COVID19
patients, higher serum levels of kynurenic acid (a tryptophan metabolite) are associated with poorer outcomes. This may offer a clue to sex-specific differences seen in the disease.
@Johnsonlab_yale
@VirusesImmunity
Happy Birthday to
#Lasker
and
#Nobel
Laureate James P. Allison. He discovered and developed a monoclonal antibody therapy that unleashes the immune system to combat cancer.
@MDAndersonNews
The 2019 Lasker~Bloomberg Public Service Award honors Gavi, the Vaccine Alliance (
@gavi
) for providing sustained access to childhood vaccines around the globe, saving millions of lives, and for highlighting the power of immunization to prevent disease.
โIt wasn't that I was going out and trying to say, โI wanna find a way to cure
#cancer
.โ Not at all. That wasn't in my head at all. I wanted to understand how T-cells work.โ โJim Allison
#immunotherapy
The 2019 Lasker~DeBakey Clinical Medical Research Award honors H. Michael Shepard, Dennis J. Slamon, and Axel Ullrich for the invention of Herceptinโa targeted antibody therapy for breast cancer.
#Mitochondria
require glutathione (GSH) to perform their daily functions, but how they import it has remained mysteriousโuntil now. Scientists have identified the protein SLC25A39 as an essential transporter of mitochondrial GSH.
@KivancBirsoy
Congratulations to
@NIH
#Lasker
Clinical Research Scholar Andrea Apolo on receiving tenure at
@theNCI
! Read about her research on genitourinary tumors:
@apolo_andrea
Cells connect with their environment through surface receptors and use physical tension to regulate cellular processes. A new study develops an overstretching tension sensor to allow more accurate force measurement in physiological conditions.
@taekjip
Tomorrow is International Day of Women and Girls in Science!
#LaskerLaureate
@kkariko
, when accepting her award, hoped that young girls would be inspired by her story. Listen to her message in the video below.
#IDWGIS
Brown adipose tissue (BAT) is a possible therapeutic target for controlling diabetes and
#obesity
. New work reveals that BAT cells can be derived from vascular smooth muscle cells expressing the
#ionchannel
#Trpv1
.
@FarnazShamsi
@tsengyuhua
.
@Stanford
researchers solve the structure of the human sodium-chloride cotransporter (NCC) alone and in complex with the diuretic polythiazide. This could aid in
#rationaldrugdesign
of
#hypertension
treatments that donโt cause unwanted side effects.
Brown and Goldstein won the
#LaskerAward
and the
#NobelPrize
in 1985. Read about the beginnings of this dynamic duo and the chance encounter that led them to their Award-winning work on cholesterol metabolism.
@UTSWNews
New research suggests that RNA transcripts provide a feedback mechanism for transcriptional condensate formation: low levels of RNA help trigger formation, but the surge of RNAs made during elongation triggers dissolution.
@WhiteheadInst
@CellCellPress
Congratulations to James G. Fujimoto, David Huang, and Eric A. Swanson, 2023
#LaskerAward
winners! โ โfor the invention of optical coherence tomography, a technology that revolutionized ophthalmologyโ.
#Lasker2023
#LaskerLaureate
#OCT
Israel Kleiner recognized
#insulin
and its potential for treating people with
#diabetes
years before the treatment became available. โIn 1919, for reasons that were unknown, his work abruptly ceased,โ Jeff Friedman said. โI decided to try to find out why.โ
We wish
#LaskerAward
winner Victor R. Ambros a happy birthday! By studying the microscopic worm C. elegans, he discovered that small RNAs are key regulators of gene expression.
@UMassMedical
#modelorganism
The changes to histones during the transition from totipotency to pluripotency have remained unclearโuntil now. A new study shows that SUMOylation (a post-translational modification) of linker
#histone
H1 represses totipotency.
@YMerbl
@jacob_hanna
Happy birthday to
#LaskerLaureate
Bertil Hille! Hille was recognized for his work on
#ionchannels
, which govern the electrical potential of membranes, generating nerve impulses and controlling muscle contraction, cardiac rhythm, and hormone secretion.
Happy 91st Birthday to
#LaskerLaureate
James E. Darnell Jr. of
@RockefellerUniv
! He launched the fields of RNA processing and cytokine signaling, while mentoring and fostering the careers of more than 125 scientists.
#RNAbiology
โYoung people have good, naรฏve questions that are not constrained by what they think they already know.โ โ2022
#LaskerAward
winner Richard O. Hynes of
@MIT
on the importance of young people in
#STEM
.
#LaskerLaureate
#Lasker2022
#LaskerLaureate
David Allis of
@RockefellerUniv
discusses the importance of choosing the right lab environment. He does an amazing job of supporting and
#mentoring
the people of his lab. Each of the laureates who are here today hold that standard!
Happy Birthday, David C Allis! He received a
#LaskerAward
in 2018 for discoveries elucidating how gene expression is influenced by chemical modification of histonesโthe proteins that package DNA within chromosomes.
@RockefellerUniv
Scientists record changes in transcription over time by fluorescently labeling circulating immune cells before they infiltrate a tumor. Their findings shed light on how immune cells become dysfunctional in a tumor environment.
@IdoAmitLab
Congratulations to Hussain Lalani, winner of the 2022
#LaskerEssay
Contest. Read his winning essay, โI Would Be Scared If I Heard That Tooโ in our July Newsletter:
@BrighamWomens
@DrHussainL
Happy birthday to Tom Maniatis, who won the Lasker~Koshland Special Achievement Award in 2012. He was recognized for exceptional leadership and citizenship in biomedical science, including fundamental discoveries concerning the nature of
#genes
.
@Columbia
Join us NOW to meet the 2021
#LaskerAward
winners! Dieter Oesterhelt, Peter Hegemann, and Karl Deisseroth; Katalin Karikรณ and Drew Weissman; David Baltimore.
#Lasker2021
#LaskerLaureate
Happy Birthday to
#Lasker
Laureate William Kaelin! He discovered the pathway by which cells from humans and most animals sense and adapt to changes in oxygen availability.
@kaelin_lab
@harvardmed
@DanaFarber
Proximity to nuclear specklesโareas dense in mRNA splicing regulatorsโdetermines mRNA splicing efficiency. Variation in distance between genes and nuclear speckles drives cell-type specific differences in splicing.
@_prashantbhat
@mitchguttman
Two years ago,
@KivancBirsoy
et al. identified SLC25A39 as an essential transporter of mitochondrial glutathione (GSH). Now, they show how SLC25A39 levels are regulated to control GSH homeostasis.
@YuyangLiu1996
#Mitochondria
require glutathione (GSH) to perform their daily functions, but how they import it has remained mysteriousโuntil now. Scientists have identified the protein SLC25A39 as an essential transporter of mitochondrial GSH.
@KivancBirsoy
What technical advances were needed to develop
#OCT
and how has it changed ophthalmology?
#Lasker
Jury Member Jeremy Nathans walks us through the past, present, and future of this revolutionary technique.
#LaskerAward
#Lasker2023
George E. Palade was born
#OTD
. He won a
#LaskerAward
for using electron
#microscopy
to map the structures of cells. He developed the technique of fixing cells, and he was the first to describe the fine structures of mitochondria.
@RockefellerUniv
"Female scientists are under-represented in global research.
@nature
has long argued the need for initiatives to increase their opportunities and participation." New awards aim to celebrate
#WomenInScience
Happy birthday to Ronald Evans! He won a
#LaskerAward
for the discovery of the superfamily of nuclear hormone receptors and elucidation of a unifying mechanism that regulates embryonic development and diverse metabolic pathways.
@salkinstitute
Congratulations to the 2022
#LaskerAward
winners! โ Richard O. Hynes, Erkki Ruoslahti, Timothy A. Springer (
@timothyspringer
); Yuk Ming Dennis Lo; Lauren Gardner (
@TexasDownUnder
)
Missed the announcement? You can watch the entire video here
Congratulations to our Essay Contest winner Avash Das! A PhD candidate at UT Southwestern,
@avash22
writes that physician scientists are like the โRosetta Stoneโ, bridging the gap between clinical medicine and biomedical research. Read more:
@UTSWNews
2021 marks 50 years of the National Cancer Act. Mary
#Lasker
played a pivotal role in passing this legislation, which created a nationally coordinated
#cancer
research program under the leadership of
@theNCI
.
#NothingWillStopUs