Should you exercise, even if you are sleep-deprived?
Yes!
Sleep restriction attenuates protein synthesis
When incorporating exercise, protein synthesis levels are reversed back to control levels
Fun fact—I was one of the participants in this study
It is never too late to start exercising
8 weeks of resistance training in adults 86 to 96 years of age
180%⬆️in strength
9%⬆️in muscle size
48%⬆️in gait speed
Minimal-Dose Resistance Training for Improving Muscle Mass, Strength, and Function: A Narrative Review of Current Evidence and Practical Considerations
How effective is performing 100-150 reps per set?
This study compared the effects of
3 sets of 6-8 reps
2 sets of 30-40 reps
1 set of 100-150 reps
Strength gains were 20%, 8%, and 5%, respectively
Endurance gains were 28%, 41%, and 39%, respectively
Hip thrust or back squat for hypertrophy?
Gluteus maximus
Hip thrust = 11-22%
Squat = 10-19%
Gluteus medius and minimum
Hip thrust = 3%
Squat = 1%
Quads
Hip thrust = 7%
Squat = 13%
Adductors
Hip thrust = 4%
Squat = 10%
Full squat or parallel squat for muscle hypertrophy?
Quads (vasti muscles)
Full squat = 4.9%
Parallel squat = 4.6%
Adductor
Full squat = 6.2%
Parallel squat = 2.7%
Gluteus
Full squat = 6.7%
Parallel squat = 2.2%
Hams
No change in either group
3 sets of 10-second maximum isometric contraction for 100 days [every day except Sunday]
1 minute of rest between sets
After 100 days = 23% increase in muscle size
23% increase for daily total training of 3 minutes 30 seconds
It does not take much
The benefits of exercise are really incredible
This study found that both aerobic and resistance exercise rejuvenates aging skin
Both interventions improved skin elasticity and upper dermal structure
Resistance exercise also improved dermal thickness
Alcohol impairs protein synthesis!🍺
After exercise, the participants consumed:
Whey protein
Alcohol + protein
Alcohol + carbohydrate
Alcohol ingestion resulted in lower protein synthesis compared to protein alone (32-39% vs. 52%)
Caffeine and strength gains ☕️🏋️♀️
3 mg/kg of caffeine pre-exercise
vs.
Placebo
6 weeks of training
1RM squat gain
Caffeine = 26%
Placebo = 9%
1RM bench press gain
Caffeine = 15%
Placebo = 9%
Do We Need a Cool-Down After Exercise? A Narrative Review of the Psychophysiological Effects and the Effects on Performance, Injuries and the Long-Term Adaptive Response
How many reps can we perform at a given 1RM%?
Here are the estimates
95% 1RM = 3
90% 1RM = 5
85% 1RM = 7
80% 1RM = 10
75% 1RM = 12
70% 1RM = 15
65% 1RM = 17
60% 1RM = 20
The values vary by exercise; more can be performed in the leg press vs. bench press
How about performing 18 sets of 1RM bench press (yes, 18 × 1RM)
Exercise program was carried out 1, 2, 3, 4, or 5 days/week
After 9 weeks, 1RM increased by:
1 day = 20 pounds
2 days = 23 pounds
3 days = 30 pounds
4 days = 32 pounds
5 days = 42 pounds
Freezing your gains 🥶
Cold water immersion [CWI] post-exercise (15 min at 10°C)
vs.
Passive recovery
Type I fiber hypertrophy
CWI = 5%
Passive recovery = 9%
Type II fiber hypertrophy
CWI = –4%
Passive recovery = 23%
Training a muscle 2 or 4 times per week?
1-2 sets per exercise 4 × week
vs.
2-4 sets per exercise 2 × week
Both groups increased strength and muscle size, with no between-group differences
When volume is equated, frequency is of less importance
How much volume is needed to retain muscle size?
After a 16-week program, participants were randomized to:
Detraining (no exercise)
1/3 of the volume of the initial program
1/9 of the volume of the initial program
Detraining resulted in a loss of size
1/3 of the volume further
Losing fat and gaining muscle at the same time?
8 weeks of resistance training + a diet that included a 1000 kcal/day deficit
Results?
Lean body mass⬆️by 0.43 kg
Upper arm volume⬆️by 6%
Fat weight⬇️by 4.3 kg
Body fat percentage⬇️by 3.8%
You have likely used paracetamol (acetaminophen) for pain relief and fever reduction
Did you know that studies explored the effects of paracetamol on exercise performance?
I reviewed the evidence, and the findings may be surprising
THREAD (1/9)🧵⬇️
Protein ingestion before sleep
No protein
20 g casein protein
20 g casein protein + 1.5 g leucine
40 g casein protein
Overnight myofibrillar protein synthesis rates for the four conditions
33%
37%
39%
44%
Could aerobic training help to increase muscle size?
6 wks of aerobic training + 10 wks of resistance training [A+RT]
vs.
10 wks of resistance training [RT]
Type I fiber hypertrophy
A+RT = 19%
RT = 2%
Type II fiber hypertrophy
A+RT = 40%
RT = 19%
Do you use the 1RM test in research or in practice?
If yes, make sure to give our latest paper a read: "Test-Retest Reliability of the One-Repetition Maximum (1RM) Strength Assessment: a Systematic Review" 🏋️💪
@BradSchoenfeld
@Zeljko_Pedisic
FREE
If you want to⬆️the number of calories your body is spending while you are completely at rest, consider doing resistance exercise
This study found that 24 weeks of resistance exercise increased resting metabolic rate by 7-9% (around 90-140 kcal/day)
Feeling anxious? Exercise might help
Resistance exercise⬇️anxiety symptoms
⬇️in anxiety symptoms were found among healthy participants and those with physical or mental illness
Which exercises are the best for gluteus maximus activation?
This review found that the highest activation occurs during different variations of step-ups
Other high-activation exercises also include deadlifts, hip thrusts, and squats
Synergistic effects of creatine and protein
Whey protein + creatine vs. whey protein vs. placebo
Lean body mass
Whey protein+creatine = 6.5%
Whey protein = 3.8%
Placebo = 1.5%
1RM bench press
Whey protein+creatine = 17%
Whey protein = 7%
Placebo = 8%
10000 steps a day keeps the doctor away? 🚶🧑⚕️
After a high-fat mixed meal participants completed:
2500 steps
5000 steps
10000 steps
15000 steps
Postprandial lipemia—a cardiovascular disease risk factor—was the lowest after 10K steps
New research on free-weight vs. machine-based strength training
Using free-weight exercises⬆️strength more in free-weight exercises
Using machine-based exercises⬆️strength more in machine-based exercises
No significant differences in hypertrophy
What is the effect of vitamin C and E supplementation on muscle mass?
34 males (60–81 yrs)
2 groups:
- Antioxidant group (500 mg of vitamin C and 117.5 mg vitamin E)
- Placebo
After 12 weeks, the⬆️in muscle thickness was larger in the placebo group
Periodic vs. continuous training
This study compared:
1. Continuous training for 24 weeks
2. Periodic training—6 weeks of training followed by 3 weeks of rest (repeated x3)
Improvements in muscle size and strength were similar between the groups
Avoid the use of smartphones before your workout
30-minute exposure to smartphone social network apps before exercise
⬆️ Perception of mental fatigue
⬇️ Volume load during 3 sets of squats to failure
What type of training is better?
6 sets of 4 repetitions to failure
or
3 sets of 10 repetitions to failure
After 10 weeks, similar gains were found for 1RM strength and muscle cross-sectional area
Training only one limb also results in strength gain in the opposite, untrained limb
This phenomenon is defined as 'cross education'
This effect is likely mediated by changes in motor pathways and motor areas involved in the control of the movement
Short rest between sets may hinder your gains
This study compared protein synthesis responses when training with:
1 min of rest between sets
5 min of rest between sets
0-4 hours post-exercise, protein synthesis was higher when resting for 5 min
Training 1 or 2 times per day?
One group performed 16 sets once per day
Second group performed 8 sets twice per day
1RM squat strength gains were greater when training twice per day, 16% vs. 8%
Similar hypertrophy in both groups
Is stronger better?
A 3-week strength-oriented training period (4x1-3 RM) + 5-week hypertrophy-oriented period (4x8-12RM) is better for strength and hypertrophy than 8 weeks of hypertrophy-only training
You are as fast as your motor neurons: Speed of recruitment and maximal discharge of motor neurons determine the maximal rate of force development in humans
What does training for 13 hours over 6 days have on physiology and performance?
50% increase in training volume resulted with
⬇ time to exhaustion
⬇ VO2max
⬇ max lactate
⬇ heart rate
⬇ resting cortisol
⬆ plasma volume
Overtraining does exist
Lifting weights fast or slow?
Squats, 3 × 8-12 repetitions, 7.5 weeks
Lifting the weight as fast as possible in the concentric phase
vs.
Lifting the weight in a slow manner (around 4-6 seconds)
Quad hypertrophy
Fast = 21%
Slow = 17%
Consuming protein helps to improve muscle strength, but only up to a certain point.
This analysis indicates that the threshold may be around 1.5 grams per kg of body weight/day
You are as fast as your motor neurons: speed of recruitment and maximal discharge of motor neurons determine the maximal rate of force development in humans
520 calories per day for 3 months?
4 groups of obese individuals were on this diet
Diet only
Diet + endurance training
Diet + resistance training
Diet + endurance and resistance
Weight loss = 20-22 kg
Resting metabolic rate = -140 to -220 kcal
Protein synthesis during energy restriction
5 days of ∼800 kcal/d followed by the ingestion of 15, 35, or 60 g of whey
vs.
5 days of ∼1785 kcal/d + 35 g of whey
35-60 g of whey produced maximal protein synthesis, regardless of total calorie intake
How to lose fat and gain muscle at the same time?
17 resistance-trained females
8 weeks of resistance training, 4 times per week, 3-5 sets of 3-16 repetitions
+
High protein diet = 2.5 g/kg/day
After 8 weeks
2.1 kg⬆️in fat-free mass
1.1 kg⬇️In fat mass
What can happen to a muscle in 12 years [if you are not active]?
Strength⬇️by 24-30%
Muscle cross-sectional area⬇️by 12-26%
Capillary density⬇️by 20%
You gotta lift!
No weights, no problem!
NO LOAD training—contracting the muscle through the full range of motion without any load—may still increase muscle size and strength
How long can you maintain muscle size during detraining?
This study found a 5.5%⬆️in muscle size during 3 months of training
After 1 month of detraining, muscle size⬇️by 4%
After 2 months of detraining, muscle size⬇️to pre-training levels
Protein sources matter!
This study compared the effects of three protein sources on amino acid bioavailability
Protein bolus (~15 g) was ingested from:
Cricket (insect)
Pea
Whey
The highest concentration of amino acids was after the ingestion of whey
More protein is generally consumed at dinner vs. breakfast
That might not be ideal
Even distribution (30 g at breakfast, lunch, and dinner) is better for protein synthesis than a skewed distribution (10 g at breakfast, 16 g at lunch, and 64 g at dinner)
Spot fat reduction with extremely high rep training?
Participants performed 1 set of 960–1200 reps of unilateral leg press, 3 × week for 12 weeks
Overall fat mass⬇️by 5.1%
Body fat⬇️in the upper body, not in the legs
No support for spot fat reduction
Energy availability and protein synthesis
For 10 days, the participants consumed
Low energy—25 kcal/kg fat-free mass/day
Optimal energy—50 kcal/kg fat-free mass/day
Total protein was matched
Protein synthesis was ~20% lower in the low-energy group
Pull-up performance and body fat 🏋️
For a 10% ⬆️in body mass (due to body fat), pull-up performance is ⬇️by 50%
Example:
A 75 kg male can do 12 pull-ups
If he gains 7.5 kg of body fat, the number of pull-ups will be reduced to 6
More on very high repetition resistance training
2 sets of 10-15 reps at 80% 1RM
1 set of 80-100 reps at 20% 1RM
1 set of 60 reps at 20% 1RM, followed by 1 set of 10-20 reps at 40% 1RM
Similar increases in muscle size in all three groups (∼3%)
Use the egg white and throw away the yolk
Or maybe not
Ingestion of whole egg resulted in greater stimulation of protein synthesis than did the ingestion of egg whites [matched for protein content]
Volume is great, but how much do we need?
Resistance-trained males (1RM squat was 2 x body weight) performed:
12 sets per muscle per week
18 sets per muscle per week
24 sets per muscle per week
1RM strength
12 sets = 11%
18 sets = 16%
24 sets = 5%
Exploring the Dose-Response Relationship Between Estimated Resistance Training Proximity to Failure, Strength Gain, and Muscle Hypertrophy: A Series of Meta-Regressions
Training for 2 years using the same program
Strength gain
⬆️32-90%
Tended to linearly increase with training (except during detraining for 8 weeks)
Muscle size
⬆️8.7%
2/3 of these gains were observed in year 1
What would have happened in year 3?
How much protein can the body use in a single meal for muscle-building? Implications for daily protein distribution 🍳💪
To reach 1.6 g/kg/day, go for 0.4 g of protein/kg/meal in 4 meals
To reach 2.2 g/kg/day, go for 0.55 g of protein/kg/meal in 4 meals
Does resistance training increase the number of muscle fibers [hyperplasia], or only their size [hypertrophy]?
12 weeks of resistance training
⬆️biceps brachii muscle cross-sectional area
⬆️type I and II muscle fiber size
No change in the fiber number
Strength training increases both strength and flexibility
Flexibility training only improves flexibility
If you want more bang for the buck the choice is clear
Daily 1RM training in powerlifters and weightlifters
During 5 weeks of training, participants performed 1 × 1RM squat and 5 × 2-3 reps at 85-90% 1RM
The results?
Gain in 1RM squat strength ranged from 5 kg to 21 kg
Muscle growth occurs very early when starting a resistance training program
How soon?
This study found significant increases in muscle thickness in the second week of training
Steroids and the power of placebo
The coach gave varsity athletes pills stating that they were steroids (Dianabol), even though a placebo was actually given
Strength gain
First 7 weeks (no "steroids") = 1-3%
Last 4 weeks ("steroid" treatment) = 6-14%
Are you in an energy deficit?
Consider these 2 findings
1. An average deficit of 500 kcal/day limits gains in lean body mass 💪
2. Strength gain seems to be less affected by energy deficits 🏋️
How much rest do you need between sets when training for hypertrophy?
What does the latest evidence suggest?
The ultimate guide in the 🧵⬇️
THREAD (1/10)
If your goal is to maximize protein synthesis, how much should you ingest per meal?
This review estimated that protein synthesis is maximized when ingesting 0.31 grams per kg of body mass
For an 80 kg individual, that would be around 25 grams of protein
Do we need to train to failure?
Training using 0–1 repetitions-in-reserve (essentially training to failure)
vs.
4–6 repetitions-in-reserve (4–6 repetitions before failure)
1RM squat, bench press, and deadlift increased similarly in both groups
The Effect of Hormonal Contraceptive Use on Skeletal Muscle Hypertrophy, Power and Strength Adaptations to Resistance Exercise Training: A Systematic Review and Multilevel Meta-analysis
Changes in the proportion of muscle fibers with training
6 sprinters (100m results: 10.47-11.34 s)
Sprint/strength training
3 months, 6 days per week, 2.5-3 hours per day
7%⬇️in the proportion of type I fibers
16%⬆️in the proportion of type IIA fibers