Our understanding of the pathophysiology of obesity remains at best incomplete despite a century of research. During this time, two alternative perspectives have helped shape thinking about the...

A new, major study supports the “Carbohydrate Insulin Model” of obesity

The members of the team that discovered insulin sold the patent to the University of Toronto for $1 each because they felt that the drug belonged to the public. Nearly 100 years later, insulin is i...

A study of modern hunter-gatherer groups found that they exhibit generally excellent metabolic health while consuming a wide range of diets.

Lower-carbohydrate diets transiently reduce TEE, with a larger increase after ∼2.5 wk. These findings highlight the importance of longer trials to understand chronic macronutrient effects and suggest...

I could eat the foods I enjoyed and most of my regular meals, but it had to be within a short time frame of eight to 10 hours.

This cluster randomized clinical trial of urban schools participating in the federal School Breakfast Program evaluates the effects of providing breakfast in the classroom at the beginning of the...

Sugar in mouse diets promotes metabolic disease by upsetting the gut microbial balance and driving loss of the Th17 cells that regulate lipid absorption by the intestinal epithelium.

This case-control study compares trajectories of dementia cardiometabolic risk factors in individuals older than 65 years who develop vs those who do not develop dementia.

International Journal of Obesity - Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

PURPOSE Adults with a triple multimorbidity (hypertension, prediabetes or type 2 diabetes, and overweight or obesity), are at increased risk of serious health complications, but experts disagree on...

We reviewed over 100 studies and conclude that milk recommendations for Americans are not based in evidence

Can the AH Solution help you control Type 1 Diabetes? Discover the science and research behind a low-carb diet, and its relationship to diabetes.

The huge burden of obesity and other chronic conditions among people in the U.S. puts most of us at direct risk.

NEW YORK (AP) — It may seem like a contradiction, but more adults in the U.S. say they are exercising at the same time more of them are becoming obese.

A new, major study supports the “Carbohydrate Insulin Model” of obesity

The journal Science has published a short opinion essay on the “failure” of the Carbohydrate-Insulin Model of obesity (CIM) to explain the results of half a dozen experimental tests. This brings to…

Conventional obesity treatment, based on the First Law of Thermodynamics, assumes that excess body fat gain is driven by overeating, and that all calories are metabolically alike in this regard....

Nature Communications - Dietary fatty acids have different effects on human health. Here, the authors show that ingestion of the fatty acid C18:0, but not of C16:0, rapidly leads to fusion of...

Overall, melatonin intake for 12 weeks to diabetic patients with CHD had beneficial effects on plasma GSH, NO, MDA, PCO, serum hs-CRP levels, glycemic control, HDL-cholesterol, total-/HDL-cholesterol...

European Journal of Nutrition - The relationship between sugar consumption and various health-related sequelas is controversial. Some investigators have argued that excessive sugar consumption is...

Leaked documents have revealed the secret tactics used by a food industry front group to sanitise negative messages about breakfast cereals

Objective To comprehensively examine the associations between changes in carbohydrate intake and weight change at four year intervals. Design Prospective cohort study. Setting Nurses’ Health Study...

Carbohydrates, not calories, are to blame for obesity.

Resistance at the brain receptors for leptin and insulin has been associated with increased feeding, obesity and cognitive impairments. The causal agent for central resistance is unknown but could be...

Nature - Glucose–insulin feedback can reactivate PI3K in tumours treated with PI3K inhibitors, reducing therapeutic efficacy, but this effect can be reduced by using drugs or diet to suppress...

AbstractBackground. Evidence is accumulating that high dietary glycaemic index (GI) and glycaemic load (GL) are potential risk factors for several metaboli

Objective: The rampant growth of obesity worldwide has stimulated explosive research into human metabolism. Energy expenditure has been shown to be altered by diets differing in macronutrient...

What if overeating doesn’t make you fat?

Conventional antiseizure medications reduce neuronal excitability through effects on ion channels or synaptic function. In recent years, it has become clear that metabolic factors also play a crucial...

This study uses publicly available data to analyze research and development spending to win FDA approval and bring new drugs to market between 2009 and 2018.

This systematic review and meta-analysis summarize evidence on the temporality of the association between higher body mass index and chronic inflammation and/or hyperinsulinemia.

Nearly one in seven Americans now has diabetes, a record rate. The condition also raises the risk of severe illness after coronavirus infection.

Replacement of DBs with water after the main meal in obese adult women with type 2 diabetes may lead to more weight reduction during a weight loss program.

This Medical News article discusses evidence for ketone body supplementation as a novel cardiovascular disease treatment.

Putting on weight is often blamed on overeating, but new evidence is emerging that it is actually the other way round, says David S. Ludwig

How several former vegans and vegetarians across the country came to see meat as their calling.

Background There are limited data regarding the timing of carbohydrate ingestion during a meal and postprandial glucose regulation. Methods Sixteen subjects with type 2 diabetes mellitus (T2DM)...